eF-site ID 3g60-AB
PDB Code 3g60
Chain A, B

click to enlarge
Title Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
Classification MEMBRANE PROTEIN
Compound Multidrug resistance protein 1a
Source (Q5I1Y5_MOUSE)
Sequence A:  VSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFG
DMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEEMTTYAY
YYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIM
NQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQA
MATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKIL
SSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELER
YNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWY
GTSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFA
NARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKN
IHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTT
VQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQE
PVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKL
PHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDE
ATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNAD
VIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTLDEDVP
PASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFS
KVVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQ
GFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGA
LTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIY
GWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGS
GKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMK
KAHVFGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFEN
VLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIE
KTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVL
QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGS
VFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAY
GDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKG
TQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKV
VQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKE
HGTHQQLLAQKGIYFSMVSVQA
B:  VSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFG
DMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEEMTTYAY
YYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIM
NQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQA
MATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKIL
SSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELER
YNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWY
GTSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFA
NARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKN
IHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTT
VQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQE
PVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKL
PHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDE
ATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNAD
VIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTLDEDVP
PASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFS
KVVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQ
GFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGA
LTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIY
GWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGS
GKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMK
KAHVFGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFEN
VLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIE
KTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVL
QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGS
VFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAY
GDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKG
TQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKV
VQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKE
HGTHQQLLAQKGIYFSMVSVQA
Description


Functional site

1) chain A
residue 303
type
sequence Y
description BINDING SITE FOR RESIDUE 0JZ A 6001
source : AC1

2) chain A
residue 332
type
sequence F
description BINDING SITE FOR RESIDUE 0JZ A 6001
source : AC1

3) chain A
residue 335
type
sequence L
description BINDING SITE FOR RESIDUE 0JZ A 6001
source : AC1

4) chain A
residue 336
type
sequence I
description BINDING SITE FOR RESIDUE 0JZ A 6001
source : AC1

5) chain A
residue 339
type
sequence F
description BINDING SITE FOR RESIDUE 0JZ A 6001
source : AC1

6) chain A
residue 721
type
sequence Q
description BINDING SITE FOR RESIDUE 0JZ A 6001
source : AC1

7) chain A
residue 724
type
sequence F
description BINDING SITE FOR RESIDUE 0JZ A 6001
source : AC1

8) chain A
residue 725
type
sequence S
description BINDING SITE FOR RESIDUE 0JZ A 6001
source : AC1

9) chain A
residue 728
type
sequence F
description BINDING SITE FOR RESIDUE 0JZ A 6001
source : AC1

10) chain A
residue 949
type
sequence Y
description BINDING SITE FOR RESIDUE 0JZ A 6001
source : AC1

11) chain A
residue 975
type
sequence S
description BINDING SITE FOR RESIDUE 0JZ A 6001
source : AC1

12) chain A
residue 978
type
sequence V
description BINDING SITE FOR RESIDUE 0JZ A 6001
source : AC1

13) chain A
residue 981
type
sequence A
description BINDING SITE FOR RESIDUE 0JZ A 6001
source : AC1

14) chain B
residue 68
type
sequence M
description BINDING SITE FOR RESIDUE 0JZ B 6002
source : AC2

15) chain B
residue 71
type
sequence F
description BINDING SITE FOR RESIDUE 0JZ B 6002
source : AC2

16) chain B
residue 332
type
sequence F
description BINDING SITE FOR RESIDUE 0JZ B 6002
source : AC2

17) chain B
residue 339
type
sequence F
description BINDING SITE FOR RESIDUE 0JZ B 6002
source : AC2

18) chain B
residue 721
type
sequence Q
description BINDING SITE FOR RESIDUE 0JZ B 6002
source : AC2

19) chain B
residue 724
type
sequence F
description BINDING SITE FOR RESIDUE 0JZ B 6002
source : AC2

20) chain B
residue 728
type
sequence F
description BINDING SITE FOR RESIDUE 0JZ B 6002
source : AC2

21) chain B
residue 949
type
sequence Y
description BINDING SITE FOR RESIDUE 0JZ B 6002
source : AC2

22) chain B
residue 971
type
sequence L
description BINDING SITE FOR RESIDUE 0JZ B 6002
source : AC2

23) chain B
residue 974
type
sequence F
description BINDING SITE FOR RESIDUE 0JZ B 6002
source : AC2

24) chain B
residue 975
type
sequence S
description BINDING SITE FOR RESIDUE 0JZ B 6002
source : AC2

25) chain B
residue 978
type
sequence V
description BINDING SITE FOR RESIDUE 0JZ B 6002
source : AC2

26) chain B
residue 981
type
sequence A
description BINDING SITE FOR RESIDUE 0JZ B 6002
source : AC2

27) chain A
residue 527-541
type prosite
sequence LSGGQKQRIAIARAL
description ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL
source prosite : PS00211

28) chain A
residue 1172-1186
type prosite
sequence LSGGQKQRIAIARAL
description ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL
source prosite : PS00211

29) chain A
residue 44-66
type TRANSMEM
sequence WLDRLYMLVGTLAAIIHGVALPL
description Helical
source Swiss-Prot : SWS_FT_FI2

30) chain A
residue 851-870
type TRANSMEM
sequence WQLTLLLLAIVPIIAIAGVV
description Helical
source Swiss-Prot : SWS_FT_FI2

31) chain A
residue 931-953
type TRANSMEM
sequence AHVFGITFSFTQAMMYFSYAACF
description Helical
source Swiss-Prot : SWS_FT_FI2

32) chain A
residue 970-991
type TRANSMEM
sequence VLLVFSAIVFGAMAVGQVSSFA
description Helical
source Swiss-Prot : SWS_FT_FI2

33) chain B
residue 44-66
type TRANSMEM
sequence WLDRLYMLVGTLAAIIHGVALPL
description Helical
source Swiss-Prot : SWS_FT_FI2

34) chain B
residue 113-133
type TRANSMEM
sequence YYTGIGAGVLIVAYIQVSFWC
description Helical
source Swiss-Prot : SWS_FT_FI2

35) chain B
residue 183-204
type TRANSMEM
sequence GDKIGMFFQAMATFFGGFIIGF
description Helical
source Swiss-Prot : SWS_FT_FI2

36) chain B
residue 212-232
type TRANSMEM
sequence LVILAISPVLGLSAGIWAKIL
description Helical
source Swiss-Prot : SWS_FT_FI2

37) chain B
residue 291-312
type TRANSMEM
sequence ANISMGAAFLLIYASYALAFWY
description Helical
source Swiss-Prot : SWS_FT_FI2

38) chain B
residue 327-348
type TRANSMEM
sequence VLTVFFSVLIGAFSVGQASPNI
description Helical
source Swiss-Prot : SWS_FT_FI2

39) chain B
residue 708-728
type TRANSMEM
sequence VVGIFCAIINGGLQPAFSVIF
description Helical
source Swiss-Prot : SWS_FT_FI2

40) chain A
residue 113-133
type TRANSMEM
sequence YYTGIGAGVLIVAYIQVSFWC
description Helical
source Swiss-Prot : SWS_FT_FI2

41) chain B
residue 753-773
type TRANSMEM
sequence LLFLILGIISFITFFLQGFTF
description Helical
source Swiss-Prot : SWS_FT_FI2

42) chain B
residue 829-849
type TRANSMEM
sequence LAVIFQNIANLGTGIIISLIY
description Helical
source Swiss-Prot : SWS_FT_FI2

43) chain B
residue 851-870
type TRANSMEM
sequence WQLTLLLLAIVPIIAIAGVV
description Helical
source Swiss-Prot : SWS_FT_FI2

44) chain B
residue 931-953
type TRANSMEM
sequence AHVFGITFSFTQAMMYFSYAACF
description Helical
source Swiss-Prot : SWS_FT_FI2

45) chain B
residue 970-991
type TRANSMEM
sequence VLLVFSAIVFGAMAVGQVSSFA
description Helical
source Swiss-Prot : SWS_FT_FI2

46) chain A
residue 183-204
type TRANSMEM
sequence GDKIGMFFQAMATFFGGFIIGF
description Helical
source Swiss-Prot : SWS_FT_FI2

47) chain A
residue 212-232
type TRANSMEM
sequence LVILAISPVLGLSAGIWAKIL
description Helical
source Swiss-Prot : SWS_FT_FI2

48) chain A
residue 291-312
type TRANSMEM
sequence ANISMGAAFLLIYASYALAFWY
description Helical
source Swiss-Prot : SWS_FT_FI2

49) chain A
residue 327-348
type TRANSMEM
sequence VLTVFFSVLIGAFSVGQASPNI
description Helical
source Swiss-Prot : SWS_FT_FI2

50) chain A
residue 708-728
type TRANSMEM
sequence VVGIFCAIINGGLQPAFSVIF
description Helical
source Swiss-Prot : SWS_FT_FI2

51) chain A
residue 753-773
type TRANSMEM
sequence LLFLILGIISFITFFLQGFTF
description Helical
source Swiss-Prot : SWS_FT_FI2

52) chain A
residue 829-849
type TRANSMEM
sequence LAVIFQNIANLGTGIIISLIY
description Helical
source Swiss-Prot : SWS_FT_FI2

53) chain B
residue 233-290
type TOPO_DOM
sequence SSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELER
YNNNLEEAKRLGIKKAIT
description Cytoplasmic => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

54) chain B
residue 349-707
type TOPO_DOM
sequence EAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNL
EFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCG
KSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGV
VSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDF
IMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKIL
LLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTV
RNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTLD
EDVPPASFWRILKLNSTEWPYF
description Cytoplasmic => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

55) chain B
residue 774-828
type TOPO_DOM
sequence GKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTR
LANDAAQVKGATGSR
description Cytoplasmic => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

56) chain B
residue 871-930
type TOPO_DOM
sequence EMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQ
KFETMYAQSLQIPYRNAMKK
description Cytoplasmic => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

57) chain A
residue 134-182
type TOPO_DOM
sequence LAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTD
DVSKINEGI
description Cytoplasmic => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

58) chain A
residue 233-290
type TOPO_DOM
sequence SSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELER
YNNNLEEAKRLGIKKAIT
description Cytoplasmic => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

59) chain A
residue 349-707
type TOPO_DOM
sequence EAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNL
EFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCG
KSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGV
VSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDF
IMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKIL
LLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTV
RNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTLD
EDVPPASFWRILKLNSTEWPYF
description Cytoplasmic => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

60) chain A
residue 774-828
type TOPO_DOM
sequence GKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTR
LANDAAQVKGATGSR
description Cytoplasmic => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

61) chain A
residue 871-930
type TOPO_DOM
sequence EMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQ
KFETMYAQSLQIPYRNAMKK
description Cytoplasmic => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

62) chain B
residue 134-182
type TOPO_DOM
sequence LAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTD
DVSKINEGI
description Cytoplasmic => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

63) chain A
residue 67-112
type TOPO_DOM
sequence MMLIFGDMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEE
MTTYAY
description Extracellular => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

64) chain B
residue 729-752
type TOPO_DOM
sequence SKVVGVFTNGGPPETQRQNSNLFS
description Extracellular => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

65) chain B
residue 850
type TOPO_DOM
sequence G
description Extracellular => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

66) chain B
residue 954-969
type TOPO_DOM
sequence RFGAYLVTQQLMTFEN
description Extracellular => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

67) chain A
residue 205-211
type TOPO_DOM
sequence TRGWKLT
description Extracellular => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

68) chain A
residue 313-326
type TOPO_DOM
sequence GTSLVISKEYSIGQ
description Extracellular => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

69) chain A
residue 729-752
type TOPO_DOM
sequence SKVVGVFTNGGPPETQRQNSNLFS
description Extracellular => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

70) chain A
residue 850
type TOPO_DOM
sequence G
description Extracellular => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

71) chain A
residue 954-969
type TOPO_DOM
sequence RFGAYLVTQQLMTFEN
description Extracellular => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

72) chain B
residue 67-112
type TOPO_DOM
sequence MMLIFGDMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEE
MTTYAY
description Extracellular => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

73) chain B
residue 205-211
type TOPO_DOM
sequence TRGWKLT
description Extracellular => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

74) chain B
residue 313-326
type TOPO_DOM
sequence GTSLVISKEYSIGQ
description Extracellular => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

75) chain A
residue 423
type BINDING
sequence G
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00434
source Swiss-Prot : SWS_FT_FI4

76) chain A
residue 1066
type BINDING
sequence G
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00434
source Swiss-Prot : SWS_FT_FI4

77) chain B
residue 423
type BINDING
sequence G
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00434
source Swiss-Prot : SWS_FT_FI4

78) chain B
residue 1066
type BINDING
sequence G
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00434
source Swiss-Prot : SWS_FT_FI4

79) chain A
residue 83
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI6

80) chain A
residue 87
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI6

81) chain A
residue 90
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI6

82) chain B
residue 83
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI6

83) chain B
residue 87
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI6

84) chain B
residue 90
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI6


Display surface

Download
Links