eF-site ID 3fsl-A PDB Code 3fsl Chain A click to enlarge Title Crystal structure of tyrosine aminotransferase tripple mutant (P181Q,R183G,A321K) from Escherichia coli at 2.35 A resolution Classification TRANSFERASE Compound Aromatic-amino-acid aminotransferase Source Escherichia coli (strain K12) (TYRB_ECOLI) Sequence A:  MFQKVDAYAGDPILTLMERFKEDPRSDKVNLSIGLYYNED GIIPQLQAVAEAEARLNAQPHGASLYLPMEGLNCYRHAIA PLLFGADHPVLKQQRVATIQTLGGSGALKVGADFLKRYFP ESGVWVSDPTWENHVAIFAGAGFEVSTYPWYDEATNGVRF NDLLATLKTLQAGSIVLLHPCCHNPTGADLTNDQWDAVIE ILKARELIPFLDIAYQGFGAGMEEDAYAIRAIASAGLPAL VSNSFSKIFSLYGERVGGLSVMCEDAEAAGRVLGQLKATV RRNYSSPPNFGAQVVAAVLNDEALKASWLKEVEEMRTRIL AMRQELVKVLSTEMPERNFDYLLNQRGMFSYTGLSAAQVD RLREEFGVYLIASGRMCVAGLNTANVQRVAKAFAAVM Description Functional site 1) chain A residue 107 type sequence G description BINDING SITE FOR RESIDUE PLR A 500 source : AC1 2) chain A residue 108 type sequence G description BINDING SITE FOR RESIDUE PLR A 500 source : AC1 3) chain A residue 109 type sequence S description BINDING SITE FOR RESIDUE PLR A 500 source : AC1 4) chain A residue 140 type sequence W description BINDING SITE FOR RESIDUE PLR A 500 source : AC1 5) chain A residue 194 type sequence N description BINDING SITE FOR RESIDUE PLR A 500 source : AC1 6) chain A residue 222 type sequence D description BINDING SITE FOR RESIDUE PLR A 500 source : AC1 7) chain A residue 224 type sequence A description BINDING SITE FOR RESIDUE PLR A 500 source : AC1 8) chain A residue 225 type sequence Y description BINDING SITE FOR RESIDUE PLR A 500 source : AC1 9) chain A residue 255 type sequence S description BINDING SITE FOR RESIDUE PLR A 500 source : AC1 10) chain A residue 257 type sequence S description BINDING SITE FOR RESIDUE PLR A 500 source : AC1 11) chain A residue 258 type sequence K description BINDING SITE FOR RESIDUE PLR A 500 source : AC1 12) chain A residue 266 type sequence R description BINDING SITE FOR RESIDUE PLR A 500 source : AC1 13) chain A residue 70 type sequence Y description BINDING SITE FOR RESIDUE PLR B 500 source : AC2 14) chain A residue 255-268 type prosite sequence SFSKIFSLYGERVG description AA_TRANSFER_CLASS_1 Aminotransferases class-I pyridoxal-phosphate attachment site. SFSKifSLyGERVG source prosite : PS00105 15) chain A residue 38 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 70 type BINDING sequence Y description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 140 type BINDING sequence W description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 194 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 292 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 386 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 258 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine source Swiss-Prot : SWS_FT_FI2

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