eF-site ID 3fsi-A
PDB Code 3fsi
Chain A

click to enlarge
Title Crystal structure of a trypanocidal 4,4'-Bis(imidazolinylamino)diphenylamine bound to DNA
Classification TRANSFERASE/DNA
Compound Reverse transcriptase domain
Source Moloney murine leukemia virus (isolate Shinnick) (MoMLV) (3FSI)
Sequence A:  TWLSDFPQAWAETGGMGLAVRQAPLIIPLKATSTPVSIKQ
YPMSQEARLGIKPHIQRLLDQGILVPCQSPWNTPLLPVYR
PVQDLREVNKRVEDIHPTVPNPYNLLSGLPPSHQWYTVLD
LKDAFFCLRLHPTSQPLFAFEWRDPEMGISGQLTWTRLPQ
GFKNSPTLFDEALHRDLADFRIQHPDLILLQYVDDLLLAA
TSELDCQQGTRALLQTLGNLGYRASAKKAQICQKQVKYLG
YLLKEGQR
Description


Functional site

1) chain A
residue 91
type
sequence Q
description BINDING SITE FOR RESIDUE ACT A 378
source : AC1

2) chain A
residue 92
type
sequence S
description BINDING SITE FOR RESIDUE ACT A 378
source : AC1

3) chain A
residue 153
type
sequence D
description BINDING SITE FOR RESIDUE ACT A 379
source : AC2

4) chain A
residue 154
type
sequence A
description BINDING SITE FOR RESIDUE ACT A 379
source : AC2

5) chain A
residue 155
type
sequence F
description BINDING SITE FOR RESIDUE ACT A 379
source : AC2

6) chain A
residue 156
type
sequence F
description BINDING SITE FOR RESIDUE ACT A 379
source : AC2

7) chain A
residue 190
type
sequence Q
description BINDING SITE FOR RESIDUE ACT A 379
source : AC2

8) chain A
residue 125
type
sequence I
description BINDING SITE FOR RESIDUE ACT A 380
source : AC3

9) chain A
residue 127
type
sequence P
description BINDING SITE FOR RESIDUE ACT A 380
source : AC3

10) chain A
residue 197
type
sequence T
description BINDING SITE FOR RESIDUE ACT A 380
source : AC3

11) chain A
residue 66
type
sequence M
description BINDING SITE FOR RESIDUE ACT A 381
source : AC4

12) chain A
residue 171
type
sequence E
description BINDING SITE FOR RESIDUE ACT A 381
source : AC4

13) chain A
residue 172
type
sequence W
description BINDING SITE FOR RESIDUE ACT A 381
source : AC4

14) chain A
residue 173
type
sequence R
description BINDING SITE FOR RESIDUE ACT A 381
source : AC4

15) chain A
residue 24
type
sequence T
description BINDING SITE FOR RESIDUE ACT A 382
source : AC5

16) chain A
residue 25
type
sequence W
description BINDING SITE FOR RESIDUE ACT A 382
source : AC5

17) chain A
residue 29
type
sequence F
description BINDING SITE FOR RESIDUE ACT A 382
source : AC5

18) chain A
residue 241
type
sequence R
description BINDING SITE FOR RESIDUE ACT A 382
source : AC5

19) chain A
residue 72
type MOD_RES
sequence L
description Phosphoserine; by host => ECO:0000305|PubMed:12525616
source Swiss-Prot : SWS_FT_FI2

20) chain A
residue 95
type SITE
sequence N
description Cleavage; by viral protease => ECO:0000269|PubMed:16603535
source Swiss-Prot : SWS_FT_FI1


Display surface

Download
Links