eF-site ID 3fpz-AB PDB Code 3fpz Chain A, B click to enlarge Title Saccharomyces cerevisiae THI4p is a suicide thiamin thiazole synthase Classification BIOSYNTHETIC PROTEIN Compound Thiazole biosynthetic enzyme Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (THI4_YEAST) Sequence A:  HLNSTPVTHCLSDIVKKEDWSDFKFAPIRESTVSRAMTSR YFKDLDKFAVSDVIIVGAGSSGLSAAYVIAKNRPDLKVCI IESSVAPGGGSWLGGQLFSAMVMRKPAHLFLQELEIPYED EGDYVVVKHAALFISTVLSKVLQLPNVKLFNATCVEDLVT RPPTEKGEVTVAGVVTNWTLVTQAHGTQCXMDPNVIELAG YKNDGTRDLSQKHGVILSTTGHDGPFGAFCAKRIVDIDQN QKLGGMKGLDMNHAEHDVVIHSGAYAGVDNMYFAGMEVAE LDGLNRMGPTFGAMALSGVHAAEQILKHFAA B:  HLNSTPVTHCLSDIVKKEDWSDFKFAPIRESTVSRAMTSR YFKDLDKFAVSDVIIVGAGSSGLSAAYVIAKNRPDLKVCI IESSVAPGGGSWLGGQLFSAMVMRKPAHLFLQELEIPYED EGDYVVVKHAALFISTVLSKVLQLPNVKLFNATCVEDLVT RPPTVTVAGVVTNWTLVTQAHGTQCXMDPNVIELAGYKND GTRDLSQKHGVILSTTGHDGPFGAFCAKRIVDIDQNQKLG GMKGLDMNHAEHDVVIHSGAYAGVDNMYFAGMEVAELDGL NRMGPTFGAMALSGVHAAEQILKHFAA Description Functional site 1) chain A residue 72 type sequence G description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 2) chain A residue 74 type sequence G description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 3) chain A residue 75 type sequence S description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 4) chain A residue 76 type sequence S description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 5) chain A residue 96 type sequence I description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 6) chain A residue 97 type sequence E description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 7) chain A residue 98 type sequence S description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 8) chain A residue 99 type sequence S description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 9) chain A residue 104 type sequence G description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 10) chain A residue 105 type sequence G description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 11) chain A residue 170 type sequence V description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 12) chain A residue 207 type sequence D description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 13) chain A residue 234 type sequence T description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 14) chain A residue 235 type sequence T description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 15) chain A residue 236 type sequence G description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 16) chain A residue 237 type sequence H description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 17) chain A residue 241 type sequence F description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 18) chain A residue 242 type sequence G description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 19) chain A residue 290 type sequence G description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 20) chain A residue 291 type sequence M description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 21) chain A residue 301 type sequence R description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 22) chain A residue 302 type sequence M description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 23) chain A residue 303 type sequence G description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 24) chain A residue 305 type sequence T description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 25) chain A residue 309 type sequence M description BINDING SITE FOR RESIDUE AHZ A 1100 source : AC1 26) chain A residue 32 type sequence K description BINDING SITE FOR RESIDUE SO4 A 327 source : AC2 27) chain A residue 33 type sequence E description BINDING SITE FOR RESIDUE SO4 A 327 source : AC2 28) chain B residue 33 type sequence E description BINDING SITE FOR RESIDUE SO4 A 327 source : AC2 29) chain A residue 82 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 328 source : AC3 30) chain A residue 155 type sequence K description BINDING SITE FOR RESIDUE SO4 A 328 source : AC3 31) chain B residue 72 type sequence G description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 32) chain B residue 74 type sequence G description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 33) chain B residue 75 type sequence S description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 34) chain B residue 76 type sequence S description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 35) chain B residue 96 type sequence I description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 36) chain B residue 97 type sequence E description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 37) chain B residue 98 type sequence S description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 38) chain B residue 99 type sequence S description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 39) chain B residue 104 type sequence G description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 40) chain B residue 105 type sequence G description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 41) chain B residue 169 type sequence C description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 42) chain B residue 170 type sequence V description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 43) chain B residue 207 type sequence D description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 44) chain B residue 234 type sequence T description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 45) chain B residue 235 type sequence T description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 46) chain B residue 236 type sequence G description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 47) chain B residue 237 type sequence H description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 48) chain B residue 241 type sequence F description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 49) chain B residue 290 type sequence G description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 50) chain B residue 291 type sequence M description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 51) chain B residue 301 type sequence R description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 52) chain B residue 302 type sequence M description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 53) chain B residue 303 type sequence G description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 54) chain B residue 305 type sequence T description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 55) chain B residue 309 type sequence M description BINDING SITE FOR RESIDUE AHZ B 1101 source : AC4 56) chain B residue 82 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 327 source : AC5 57) chain B residue 155 type sequence K description BINDING SITE FOR RESIDUE SO4 B 327 source : AC5 58) chain A residue 76 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI1 59) chain B residue 97 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI1 60) chain B residue 105 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 61) chain B residue 170 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI1 62) chain B residue 207 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 63) chain B residue 237 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 64) chain B residue 291 type BINDING sequence M description source Swiss-Prot : SWS_FT_FI1 65) chain B residue 301 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 66) chain A residue 97 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI1 67) chain A residue 105 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 68) chain A residue 170 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI1 69) chain A residue 207 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 70) chain A residue 237 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 71) chain A residue 291 type BINDING sequence M description source Swiss-Prot : SWS_FT_FI1 72) chain A residue 301 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 73) chain B residue 76 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI1 74) chain A residue 205 type MOD_RES sequence X description 2,3-didehydroalanine (Cys) => ECO:0000269|PubMed:22031445 source Swiss-Prot : SWS_FT_FI2 75) chain B residue 205 type MOD_RES sequence X description 2,3-didehydroalanine (Cys) => ECO:0000269|PubMed:22031445 source Swiss-Prot : SWS_FT_FI2

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