|
|
eF-site ID
|
3fn1-AB |
|
PDB Code
|
3fn1 |
|
Chain
|
A, B |
|
click to enlarge
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Title
|
E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. |
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Classification
|
LIGASE |
|
Compound
|
NEDD8-activating enzyme E1 catalytic subunit |
|
Source
|
null (UBE2F_HUMAN) |
|
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Sequence
|
A: |
PQNIQFSPSAKLQEVLDYLTNSASLQXKSPAITATLEGKN
RTLYXQSVTSIEERTRPNLSKTLKELGLVDGQELAVADVT
TPQTVLFKLHFT
|
| B: |
STRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPNKLHCF
QLTVTPDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIW
HPNITETGEICLSLLREHSIDGTGWAPTRTLKDVVWGLNS
LFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVDDYIKRYAR
|
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
116 |
| type |
ACT_SITE |
| sequence |
C
|
| description |
Glycyl thioester intermediate => ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
B |
| residue |
105-120 |
| type |
prosite |
| sequence |
WHPNITETGEICLSLL
|
| description |
UBC_1 Ubiquitin-conjugating (UBC) active site signature. WHPNItet.GeICLslL
|
| source |
prosite : PS00183
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