|
|
eF-site ID
|
3fn1-AB |
|
PDB Code
|
3fn1 |
|
Chain
|
A, B |
|
click to enlarge
|
|
|
Title
|
E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. |
|
Classification
|
LIGASE |
|
Compound
|
NEDD8-activating enzyme E1 catalytic subunit |
|
Source
|
Homo sapiens (Human) (UBE2F_HUMAN) |
|
|
Sequence
|
A: |
PQNIQFSPSAKLQEVLDYLTNSASLQXKSPAITATLEGKN
RTLYXQSVTSIEERTRPNLSKTLKELGLVDGQELAVADVT
TPQTVLFKLHFT
|
| B: |
STRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPNKLHCF
QLTVTPDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIW
HPNITETGEICLSLLREHSIDGTGWAPTRTLKDVVWGLNS
LFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVDDYIKRYAR
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
105-120 |
| type |
prosite |
| sequence |
WHPNITETGEICLSLL
|
| description |
UBC_1 Ubiquitin-conjugating (UBC) active site signature. WHPNItet.GeICLslL
|
| source |
prosite : PS00183
|
|
|
2)
|
chain |
B |
| residue |
122 |
| type |
ACT_SITE |
| sequence |
E
|
| description |
Glycyl thioester intermediate => ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133, ECO:0000305|PubMed:23300442
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|