|
|
eF-site ID
|
3fmf-B |
|
PDB Code
|
3fmf |
|
Chain
|
B |
|
click to enlarge
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Title
|
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase complexed with 7,8 diaminopelargonic acid carbamate |
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Classification
|
LIGASE |
|
Compound
|
Dethiobiotin synthetase |
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Source
|
Mycobacterium tuberculosis (BIOD_MYCTU) |
|
|
Sequence
|
B: |
QSHMTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCK
PVQTGTARGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAA
AEHAGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVEL
AEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALA
AQQVSXAGLVIGSWPDPPGLVAASNRSALARIAMVRAALP
AGAASLDAGDFAAMSAAAFDRNWVAGLV
|
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
37 |
| type |
|
| sequence |
K
|
| description |
BINDING SITE FOR RESIDUE DSD A 250
|
| source |
: AC1
|
|
|
2)
|
chain |
B |
| residue |
40 |
| type |
|
| sequence |
Q
|
| description |
BINDING SITE FOR RESIDUE DSD A 250
|
| source |
: AC1
|
|
|
3)
|
chain |
B |
| residue |
41 |
| type |
|
| sequence |
T
|
| description |
BINDING SITE FOR RESIDUE DSD A 250
|
| source |
: AC1
|
|
|
4)
|
chain |
B |
| residue |
72 |
| type |
|
| sequence |
M
|
| description |
BINDING SITE FOR RESIDUE DSD A 250
|
| source |
: AC1
|
|
|
5)
|
chain |
B |
| residue |
73 |
| type |
|
| sequence |
A
|
| description |
BINDING SITE FOR RESIDUE DSD A 250
|
| source |
: AC1
|
|
|
6)
|
chain |
B |
| residue |
110 |
| type |
|
| sequence |
A
|
| description |
BINDING SITE FOR RESIDUE DSD A 250
|
| source |
: AC1
|
|
|
7)
|
chain |
B |
| residue |
144 |
| type |
|
| sequence |
G
|
| description |
BINDING SITE FOR RESIDUE DSD B 250
|
| source |
: AC2
|
|
|
8)
|
chain |
B |
| residue |
145 |
| type |
|
| sequence |
T
|
| description |
BINDING SITE FOR RESIDUE DSD B 250
|
| source |
: AC2
|
|
|
9)
|
chain |
B |
| residue |
146 |
| type |
|
| sequence |
L
|
| description |
BINDING SITE FOR RESIDUE DSD B 250
|
| source |
: AC2
|
|
|
10)
|
chain |
B |
| residue |
147 |
| type |
|
| sequence |
N
|
| description |
BINDING SITE FOR RESIDUE DSD B 250
|
| source |
: AC2
|
|
|
11)
|
chain |
B |
| residue |
169 |
| type |
BINDING |
| sequence |
G
|
| description |
BINDING => ECO:0000269|PubMed:30289406, ECO:0000269|DOI:10.1021/acscatal.8b03475, ECO:0007744|PDB:6CVE, ECO:0007744|PDB:6CVF, ECO:0007744|PDB:6CVU, ECO:0007744|PDB:6E05, ECO:0007744|PDB:6E06
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
12)
|
chain |
B |
| residue |
37 |
| type |
ACT_SITE |
| sequence |
K
|
| description |
ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00336
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
13)
|
chain |
B |
| residue |
11 |
| type |
BINDING |
| sequence |
T
|
| description |
BINDING => ECO:0000269|PubMed:25801336, ECO:0000269|PubMed:30289406, ECO:0000269|DOI:10.1021/acscatal.8b03475, ECO:0007744|PDB:4WOP, ECO:0007744|PDB:6CVE, ECO:0007744|PDB:6CVF, ECO:0007744|PDB:6E05, ECO:0007744|PDB:6E06
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
14)
|
chain |
B |
| residue |
197 |
| type |
BINDING |
| sequence |
P
|
| description |
BINDING => ECO:0000269|PubMed:25801336, ECO:0000269|PubMed:30289406, ECO:0000269|DOI:10.1021/acscatal.8b03475, ECO:0007744|PDB:4WOP, ECO:0007744|PDB:6CVE, ECO:0007744|PDB:6CVF, ECO:0007744|PDB:6E05, ECO:0007744|PDB:6E06
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
15)
|
chain |
B |
| residue |
16 |
| type |
BINDING |
| sequence |
T
|
| description |
BINDING => ECO:0000255|HAMAP-Rule:MF_00336, ECO:0000269|PubMed:20565114, ECO:0000269|PubMed:30289406, ECO:0000269|DOI:10.1021/acscatal.8b03475, ECO:0007744|PDB:3FPA, ECO:0007744|PDB:6CVE, ECO:0007744|PDB:6CVF, ECO:0007744|PDB:6CVV, ECO:0007744|PDB:6CZB, ECO:0007744|PDB:6CZC, ECO:0007744|PDB:6CZD, ECO:0007744|PDB:6CZE, ECO:0007744|PDB:6E05, ECO:0007744|PDB:6E06
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
16)
|
chain |
B |
| residue |
49 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000255|HAMAP-Rule:MF_00336, ECO:0000269|PubMed:20565114, ECO:0000269|PubMed:30289406, ECO:0000269|DOI:10.1021/acscatal.8b03475, ECO:0007744|PDB:3FPA, ECO:0007744|PDB:6CVE, ECO:0007744|PDB:6CVF, ECO:0007744|PDB:6CVV, ECO:0007744|PDB:6CZB, ECO:0007744|PDB:6CZC, ECO:0007744|PDB:6CZD, ECO:0007744|PDB:6CZE, ECO:0007744|PDB:6E05, ECO:0007744|PDB:6E06
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
17)
|
chain |
B |
| residue |
108 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000255|HAMAP-Rule:MF_00336, ECO:0000269|PubMed:20565114, ECO:0000269|PubMed:30289406, ECO:0000269|DOI:10.1021/acscatal.8b03475, ECO:0007744|PDB:3FPA, ECO:0007744|PDB:6CVE, ECO:0007744|PDB:6CVF, ECO:0007744|PDB:6CVV, ECO:0007744|PDB:6CZB, ECO:0007744|PDB:6CZC, ECO:0007744|PDB:6CZD, ECO:0007744|PDB:6CZE, ECO:0007744|PDB:6E05, ECO:0007744|PDB:6E06
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
18)
|
chain |
B |
| residue |
37 |
| type |
BINDING |
| sequence |
K
|
| description |
BINDING => ECO:0000269|PubMed:20565114, ECO:0000269|DOI:10.1021/acscatal.8b03475, ECO:0007744|PDB:3FMF, ECO:0007744|PDB:3FMI, ECO:0007744|PDB:6CVE
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
19)
|
chain |
B |
| residue |
41 |
| type |
BINDING |
| sequence |
T
|
| description |
BINDING => ECO:0000255|HAMAP-Rule:MF_00336
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
20)
|
chain |
B |
| residue |
144 |
| type |
BINDING |
| sequence |
G
|
| description |
BINDING => ECO:0000269|PubMed:20565114, ECO:0000269|DOI:10.1021/acscatal.8b03475, ECO:0007744|PDB:3FMF, ECO:0007744|PDB:3FMI, ECO:0007744|PDB:3FPA, ECO:0007744|PDB:6CVE
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
|