eF-site ID 3fjn-A PDB Code 3fjn Chain A click to enlarge Title The crystal structure of 17-alpha hydroxysteroid dehydrogenase Y224D mutant. Classification OXIDOREDUCTASE Compound Aldo-keto reductase family 1 member C21 Source Mus musculus (Mouse) (AK1CL_MOUSE) Sequence A:  SKCHCVILNDGNFIPVLGFGTALPLECPKSKAKELTKIAI DAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYT SKVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMAL KPGEENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKS IGVSNFNYRQLEMILNKPGLKYKPVCNQVECHPYLNQMKL LDFCKSKDIVLVAYGVLGWVDQNSPVLLDEPVLGSMAKKY NRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQL SSEDMKVLDGLNRNMRYIPAAIFKGHPNWPFLDEY Description Functional site 1) chain A residue 55 type sequence Y description BINDING SITE FOR RESIDUE ACT A 601 source : AC1 2) chain A residue 117 type sequence H description BINDING SITE FOR RESIDUE ACT A 601 source : AC1 3) chain A residue 118 type sequence Y description BINDING SITE FOR RESIDUE ACT A 601 source : AC1 4) chain A residue 167 type sequence N description BINDING SITE FOR RESIDUE ACT A 601 source : AC1 5) chain A residue 216 type sequence Y description BINDING SITE FOR RESIDUE ACT A 601 source : AC1 6) chain A residue 103 type sequence L description BINDING SITE FOR RESIDUE ACT A 801 source : AC2 7) chain A residue 107 type sequence Q description BINDING SITE FOR RESIDUE ACT A 801 source : AC2 8) chain A residue 108 type sequence F description BINDING SITE FOR RESIDUE ACT A 801 source : AC2 9) chain A residue 246 type sequence K description BINDING SITE FOR RESIDUE ACT A 801 source : AC2 10) chain A residue 55 type ACT_SITE sequence Y description Proton donor source Swiss-Prot : SWS_FT_FI1 11) chain A residue 20 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 12) chain A residue 50 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 13) chain A residue 166 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 14) chain A residue 190 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 216 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 270 type BINDING sequence T description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 17) chain A residue 31 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 18) chain A residue 117 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI3 19) chain A residue 84 type SITE sequence K description Lowers pKa of active site Tyr => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 20) chain A residue 151-168 type prosite sequence MEKCKDAGLTKSIGVSNF description ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MekckdaglTKSIGVSNF source prosite : PS00062

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