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eF-site ID
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3fey-ABC |
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PDB Code
|
3fey |
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Chain
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A, B, C |
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click to enlarge
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Title
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Crystal structure of the CBC-importin alpha complex. |
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Classification
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TRANSLATION, PROTEIN TRANSPORT |
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Compound
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Nuclear cap-binding protein subunit 1 |
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Source
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Homo sapiens (Human) (IMA2_HUMAN) |
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Sequence
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A: |
SRRRHSDENDGGQPHKRRKTSDANETEDHLESLICKVGEK
SACSLESNLEGLAGVLEADLPNYKSKILRLLCTVARLLPE
KLTIYTTLVGLLNARNYNFGGEFVEAMIRQLKESLKANNY
NEAVYLVRFLSDLVNCHVIAAPSMVAMFENFVSVTQEEDV
PQVRRDWYVYAFLSSLPWVGKELYEKKDAEMDRIFANTES
YLKRRQKTHVPMLQVWTADKPHPQEEYLDCLWAQIQKLKK
DRWQERHILRPYLAFDSILCEALQHNLPPFTPPPHTEDSV
YPMPRVIFRMFDYTDDPEGPVMPGSHSVERFVIEENLHCI
IKSHWKERKTCAAQLVSYPGKNKIPLNYHIVEVIFAELFQ
LPAPPHIDVMYTTLLIELCKLQPGSLPQVLAQATEMLYMR
LDTMNTTCVDRFINWFSHHLSNFQFRWSWEDWSDCLSQDP
ESPKPKFVREVLEKCMRLSYHQRILDIVPPTFSALCPANP
TCIYKYGDESSNSLPGHSVALCLAVAFKSKATNDEIFSIL
KDVPFNPLKIEVFVQTLLHLAAKSFSHSFSALAKFHEVFK
TLAESDEGKLHVLRVMFEVWRNHPQMIAVLVDKMIRTQIV
DCAAVANWIFSSELSRDFTRLFVWEILHSTIRKMNKHVLK
IQKELEEAKEKLARKDGVLEEQIERLQEKVESAQSEQKNL
FLVIFQRFIMILTEHLVRCETDGTSVLTPWYKNCIERLQQ
IFLQHHQIIQQYMVTLENLLFTAELDPHILAVFQQFCALQ
A
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| B: |
DSYVEEQEKLLKKSCTLYVGNLSFYTTEEQIYELFSKSGD
IKKIIMGLDTACGFCFVEYYSRADAENAMRYINGTRLDDR
IIRTDWDAGFKEGRQYG
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| C: |
MNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREK
QPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIA
SGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGN
IAGDGSVFRDLVIKYGAVDPLLALLAVSSLACGYLRNLTW
TLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADT
CWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVT
PALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNI
QKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADF
KTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTA
KDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQNHENESVYKASLSLIEKYFSVE
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Description
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Functional site
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|
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1)
|
chain |
B |
| residue |
112 |
| type |
BINDING |
| sequence |
R
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
|
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2)
|
chain |
B |
| residue |
123 |
| type |
BINDING |
| sequence |
R
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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3)
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chain |
B |
| residue |
13 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0007744|PubMed:23186163
|
| source |
Swiss-Prot : SWS_FT_FI4
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4)
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chain |
A |
| residue |
698 |
| type |
MOD_RES |
| sequence |
K
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| description |
Phosphoserine => ECO:0007744|PubMed:17525332
|
| source |
Swiss-Prot : SWS_FT_FI5
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|
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5)
|
chain |
C |
| residue |
490 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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6)
|
chain |
B |
| residue |
43 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
|
| source |
Swiss-Prot : SWS_FT_FI1
|
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