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eF-site ID
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3fex-ABC |
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PDB Code
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3fex |
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Chain
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A, B, C |
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click to enlarge
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Title
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Crystal structure of the CBC-importin alpha complex. |
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Classification
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TRANSLATION, PROTEIN TRANSPORT |
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Compound
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Nuclear cap-binding protein subunit 1 |
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Source
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Homo sapiens (Human) (IMA2_HUMAN) |
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Sequence
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A: |
SRRRHSDENDGGQPHKRRKTSDANETEDHLESLICKVGEC
SLESNLEGLAGVLEADLPNYKSKILRLLCTVARLLPEKLT
IYTTLVGLLNARNYNFGGEFVEAMIRQLKESLKANNYNEA
VYLVRFLSDLVNCHVIAAPSMVAMFENFVSVTQEVPQVRR
DWYVYAFLSSLPWVGKELYEKKDAEMDRIFANTESYLKRR
QKTHVPMLQVWTADKPHPQEEYLDCLWAQIQKLKKDRWQE
RHILRPYLAFDSILCEALQHNLPPFTPPPHTEDSVYPMPR
VIFRMFDYTDDPEGPVMPGSHSVERFVIEENLHCIIKSHW
KERKTCAAQLVSYPGKNKIPLNYHIVEVIFAELFQLPAPP
HIDVMYTTLLIELCKLQPGSLPQVLAQATEMLYMRLDTMN
TTCVDRFINWFSHHLSNFQFRWSWEDWSDCLSQDPESPKP
KFVREVLEKCMRLSYHQRILDIVPPTFSALCPANPTCIYK
YGDESSNSLPGHSVALCLAVAFKSKATNDEIFSILKDVPF
NPLKIEVFVQTLLHLAAKSFSHSFSALAKFHEVFKTLAES
DEGKLHVLRVMFEVWRNHPQMIAVLVDKMIRTQIVDCAAV
ANWIFSSELSRDFTRLFVWEILHSTIRKMNKHVLKIQKEL
EEAKEKLARKDGVLEEQIERLQEKVESAQSEQKNLFLVIF
QRFIMILTEHLVRCETDGTSVLTPWYKNCIERLQQIFLQH
HQIIQQYMVTLENLLFTAELDPHILAVFQQFCALQA
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| B: |
LLKKSCTLYVGNLSFYTTEEQIYELFSKSGDIKKIIMGLD
TACGFCFVEYYSRADAENAMRYINGTRLDDRIIRTDWDAG
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| C: |
MNQGTVNWSVDDIVKGINNVENQLQATQAARKLLSREKQP
PIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASG
TSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIA
GDGSVFRDLVIKYGAVDPLLALLAVSSLACGYLRNLTWTL
SNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCW
AISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPA
LRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQK
EATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKT
QKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKD
TKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKI
EALQNHENESVYKASLSLIEKYF
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Description
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Functional site
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|
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1)
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chain |
C |
| residue |
490 |
| type |
MOD_RES |
| sequence |
S
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| description |
Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
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| source |
Swiss-Prot : SWS_FT_FI1
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2)
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chain |
B |
| residue |
43 |
| type |
MOD_RES |
| sequence |
Y
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| description |
Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
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| source |
Swiss-Prot : SWS_FT_FI1
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3)
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chain |
B |
| residue |
112 |
| type |
BINDING |
| sequence |
R
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| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
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4)
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chain |
A |
| residue |
698 |
| type |
MOD_RES |
| sequence |
K
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| description |
Phosphoserine => ECO:0007744|PubMed:17525332
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| source |
Swiss-Prot : SWS_FT_FI5
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