eF-site ID 3fei-AZ PDB Code 3fei Chain A, Z click to enlarge Title Design and biological evaluation of novel, balanced dual PPARa/g agonists Classification TRANSCRIPTION Compound Peroxisome proliferator-activated receptor alpha Source Homo sapiens (Human) (NCOA1_HUMAN) Sequence A:  DLKSLAKRIYEAYLKNFNMNKVKARVILSPFVIHDMETLC MAEKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDL NDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITRE FLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAI ICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFL FPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQE IYRDMY Z:  HQLLRYLL Description Functional site 1) chain A residue 273 type sequence F description BINDING SITE FOR RESIDUE CTM A 1 source : AC1 2) chain A residue 276 type sequence C description BINDING SITE FOR RESIDUE CTM A 1 source : AC1 3) chain A residue 280 type sequence S description BINDING SITE FOR RESIDUE CTM A 1 source : AC1 4) chain A residue 314 type sequence Y description BINDING SITE FOR RESIDUE CTM A 1 source : AC1 5) chain A residue 318 type sequence F description BINDING SITE FOR RESIDUE CTM A 1 source : AC1 6) chain A residue 330 type sequence M description BINDING SITE FOR RESIDUE CTM A 1 source : AC1 7) chain A residue 332 type sequence V description BINDING SITE FOR RESIDUE CTM A 1 source : AC1 8) chain A residue 355 type sequence M description BINDING SITE FOR RESIDUE CTM A 1 source : AC1 9) chain A residue 440 type sequence H description BINDING SITE FOR RESIDUE CTM A 1 source : AC1 10) chain A residue 460 type sequence L description BINDING SITE FOR RESIDUE CTM A 1 source : AC1 11) chain A residue 464 type sequence Y description BINDING SITE FOR RESIDUE CTM A 1 source : AC1 12) chain A residue 433 type SITE sequence L description Essential for heterodimerization with RXRA source Swiss-Prot : SWS_FT_FI2 13) chain A residue 280 type BINDING sequence S description BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 314 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 464 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1 source Swiss-Prot : SWS_FT_FI1

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