eF-site ID 3fck-B PDB Code 3fck Chain B click to enlarge Title Complex of UNG2 and a fragment-based design inhibitor Classification HYDROLASE Compound Uracil-DNA glycosylase Source Homo sapiens (Human) (UNG_HUMAN) Sequence B:  EFFGESWKKHLSGEFGKPYFIKLMGFVAEERKHYTVYPPP HQVFTWTQMCDIKDVKVVILGQDPYHGPNQAHGLCFSVQR PVPPPPSLENIYKELSTDIEDFVHPGHGDLSGWAKQGVLL LNAVLTVRAHQANSHKERGWEQFTDAVVSWLNQNSNGLVF LLWGSYAQKKGSAIDRKRHHVLQTAHPSPLSVYRGFFGCR HFSKTNELLQKSGKKPIDWKEL Description Functional site 1) chain B residue 143 type sequence G description BINDING SITE FOR RESIDUE FCK B 1 source : AC1 2) chain B residue 144 type sequence Q description BINDING SITE FOR RESIDUE FCK B 1 source : AC1 3) chain B residue 145 type sequence D description BINDING SITE FOR RESIDUE FCK B 1 source : AC1 4) chain B residue 147 type sequence Y description BINDING SITE FOR RESIDUE FCK B 1 source : AC1 5) chain B residue 157 type sequence C description BINDING SITE FOR RESIDUE FCK B 1 source : AC1 6) chain B residue 158 type sequence F description BINDING SITE FOR RESIDUE FCK B 1 source : AC1 7) chain B residue 169 type sequence S description BINDING SITE FOR RESIDUE FCK B 1 source : AC1 8) chain B residue 204 type sequence N description BINDING SITE FOR RESIDUE FCK B 1 source : AC1 9) chain B residue 138-147 type prosite sequence KVVILGQDPY description U_DNA_GLYCOSYLASE Uracil-DNA glycosylase signature. KVVIlGQDPY source prosite : PS00130 10) chain B residue 145 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_03166 source Swiss-Prot : SWS_FT_FI1 11) chain B residue 286 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2

Display surface Download Links