eF-site ID 3f2n-A PDB Code 3f2n Chain A click to enlarge Title Crystal Structure of Human Haspin with an Imidazo-pyridazine ligand Classification TRANSFERASE Compound Serine/threonine-protein kinase haspin Source Homo sapiens (Human) (HASP_HUMAN) Sequence A:  GPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAI KIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVC NRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDR PDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILH QLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLN GKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDL FTGDGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYLTD KMLKQMTFKTKCNTPAMKQIKRKIQEFHRTMLNFSSATDL LCQHSLFK Description Functional site 1) chain A residue 490 type sequence I description BINDING SITE FOR RESIDUE IZZ A 800 source : AC1 2) chain A residue 491 type sequence G description BINDING SITE FOR RESIDUE IZZ A 800 source : AC1 3) chain A residue 509 type sequence A description BINDING SITE FOR RESIDUE IZZ A 800 source : AC1 4) chain A residue 605 type sequence F description BINDING SITE FOR RESIDUE IZZ A 800 source : AC1 5) chain A residue 606 type sequence E description BINDING SITE FOR RESIDUE IZZ A 800 source : AC1 6) chain A residue 607 type sequence F description BINDING SITE FOR RESIDUE IZZ A 800 source : AC1 7) chain A residue 608 type sequence G description BINDING SITE FOR RESIDUE IZZ A 800 source : AC1 8) chain A residue 609 type sequence G description BINDING SITE FOR RESIDUE IZZ A 800 source : AC1 9) chain A residue 611 type sequence D description BINDING SITE FOR RESIDUE IZZ A 800 source : AC1 10) chain A residue 653 type sequence G description BINDING SITE FOR RESIDUE IZZ A 800 source : AC1 11) chain A residue 656 type sequence L description BINDING SITE FOR RESIDUE IZZ A 800 source : AC1 12) chain A residue 686 type sequence I description BINDING SITE FOR RESIDUE IZZ A 800 source : AC1 13) chain A residue 687 type sequence D description BINDING SITE FOR RESIDUE IZZ A 800 source : AC1 14) chain A residue 477 type sequence H description BINDING SITE FOR RESIDUE PO4 A 900 source : AC2 15) chain A residue 563 type sequence H description BINDING SITE FOR RESIDUE PO4 A 900 source : AC2 16) chain A residue 769 type sequence Q description BINDING SITE FOR RESIDUE PO4 A 900 source : AC2 17) chain A residue 772 type sequence R description BINDING SITE FOR RESIDUE PO4 A 900 source : AC2 18) chain A residue 657 type sequence L description BINDING SITE FOR RESIDUE EDO A 901 source : AC3 19) chain A residue 658 type sequence K description BINDING SITE FOR RESIDUE EDO A 901 source : AC3 20) chain A residue 659 type sequence K description BINDING SITE FOR RESIDUE EDO A 901 source : AC3 21) chain A residue 701 type sequence F description BINDING SITE FOR RESIDUE EDO A 902 source : AC4 22) chain A residue 703 type sequence D description BINDING SITE FOR RESIDUE EDO A 902 source : AC4 23) chain A residue 705 type sequence S description BINDING SITE FOR RESIDUE EDO A 902 source : AC4 24) chain A residue 731 type sequence N description BINDING SITE FOR RESIDUE EDO A 902 source : AC4 25) chain A residue 732 type sequence R description BINDING SITE FOR RESIDUE EDO A 902 source : AC4 26) chain A residue 733 type sequence W description BINDING SITE FOR RESIDUE EDO A 902 source : AC4 27) chain A residue 734 type sequence G description BINDING SITE FOR RESIDUE EDO A 902 source : AC4 28) chain A residue 568 type sequence S description BINDING SITE FOR RESIDUE EDO A 903 source : AC5 29) chain A residue 569 type sequence Y description BINDING SITE FOR RESIDUE EDO A 903 source : AC5 30) chain A residue 574 type sequence L description BINDING SITE FOR RESIDUE EDO A 903 source : AC5 31) chain A residue 695 type sequence R description BINDING SITE FOR RESIDUE EDO A 903 source : AC5 32) chain A residue 553 type sequence T description BINDING SITE FOR RESIDUE EDO A 904 source : AC6 33) chain A residue 555 type sequence G description BINDING SITE FOR RESIDUE EDO A 904 source : AC6 34) chain A residue 631 type sequence Q description BINDING SITE FOR RESIDUE EDO A 904 source : AC6 35) chain A residue 635 type sequence S description BINDING SITE FOR RESIDUE EDO A 904 source : AC6 36) chain A residue 682 type sequence Q description BINDING SITE FOR RESIDUE EDO A 904 source : AC6 37) chain A residue 508 type sequence V description BINDING SITE FOR RESIDUE EDO A 905 source : AC7 38) chain A residue 560 type sequence N description BINDING SITE FOR RESIDUE EDO A 905 source : AC7 39) chain A residue 604 type sequence E description BINDING SITE FOR RESIDUE EDO A 905 source : AC7 40) chain A residue 776 type sequence E description BINDING SITE FOR RESIDUE EDO A 905 source : AC7 41) chain A residue 779 type sequence R description BINDING SITE FOR RESIDUE EDO A 905 source : AC7 42) chain A residue 780 type sequence T description BINDING SITE FOR RESIDUE EDO A 905 source : AC7 43) chain A residue 687 type BINDING sequence D description BINDING => ECO:0000269|PubMed:19918057 source Swiss-Prot : SWS_FT_FI4 44) chain A residue 649 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI1 45) chain A residue 490 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 46) chain A residue 511 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 47) chain A residue 490-511 type prosite sequence IGEGVFGEVFQTIADHTPVAIK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGVFGEVFqTiadhtp............VAIK source prosite : PS00107 48) chain A residue 606 type BINDING sequence E description BINDING => ECO:0000269|PubMed:19918057, ECO:0007744|PDB:3DLZ source Swiss-Prot : SWS_FT_FI3 49) chain A residue 649 type BINDING sequence D description BINDING => ECO:0000269|PubMed:19918057, ECO:0007744|PDB:3DLZ source Swiss-Prot : SWS_FT_FI3

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