eF-site ID 3f2a-A PDB Code 3f2a Chain A click to enlarge Title Crystal structure of human Pim-1 in complex with DAPPA Classification TRANSFERASE Compound Proto-oncogene serine/threonine-protein kinase Pim-1 Source null (PIM1_HUMAN) Sequence A:  EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEK DRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFE RPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQV LEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA LLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGIL LYDMVCGDIPFEHDEEIIRGQVFFRQRVSXECQHLIRWCL ALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLS Description Functional site 1) chain A residue 44 type sequence L description BINDING SITE FOR RESIDUE 985 A 1 source : AC1 2) chain A residue 49 type sequence F description BINDING SITE FOR RESIDUE 985 A 1 source : AC1 3) chain A residue 52 type sequence V description BINDING SITE FOR RESIDUE 985 A 1 source : AC1 4) chain A residue 65 type sequence A description BINDING SITE FOR RESIDUE 985 A 1 source : AC1 5) chain A residue 67 type sequence K description BINDING SITE FOR RESIDUE 985 A 1 source : AC1 6) chain A residue 120 type sequence L description BINDING SITE FOR RESIDUE 985 A 1 source : AC1 7) chain A residue 121 type sequence E description BINDING SITE FOR RESIDUE 985 A 1 source : AC1 8) chain A residue 128 type sequence D description BINDING SITE FOR RESIDUE 985 A 1 source : AC1 9) chain A residue 171 type sequence E description BINDING SITE FOR RESIDUE 985 A 1 source : AC1 10) chain A residue 172 type sequence N description BINDING SITE FOR RESIDUE 985 A 1 source : AC1 11) chain A residue 174 type sequence L description BINDING SITE FOR RESIDUE 985 A 1 source : AC1 12) chain A residue 185 type sequence I description BINDING SITE FOR RESIDUE 985 A 1 source : AC1 13) chain A residue 186 type sequence D description BINDING SITE FOR RESIDUE 985 A 1 source : AC1 14) chain A residue 67 type sequence K description BINDING SITE FOR RESIDUE MG A 314 source : AC2 15) chain A residue 89 type sequence E description BINDING SITE FOR RESIDUE MG A 314 source : AC2 16) chain A residue 186 type sequence D description BINDING SITE FOR RESIDUE MG A 314 source : AC2 17) chain A residue 187 type sequence F description BINDING SITE FOR RESIDUE MG A 314 source : AC2 18) chain A residue 37 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 76 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 170 type MOD_RES sequence D description Phosphoserine => ECO:0000269|PubMed:15657054 source Swiss-Prot : SWS_FT_FI3 21) chain A residue 44-67 type prosite sequence LGSGGFGSVYSGIRVSDNLPVAIK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGGFGSVYsGirvsdnlp..........VAIK source prosite : PS00107 22) chain A residue 163-175 type prosite sequence VLHRDIKDENILI description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDIKdeNILI source prosite : PS00108

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