eF-site ID 3etj-AB PDB Code 3etj Chain A, B click to enlarge Title Crystal structure E. coli Purk in complex with Mg, ADP, and Pi Classification LYASE Compound Phosphoribosylaminoimidazole carboxylase ATPase subunit Source Escherichia coli (strain K12) (PURK_ECOLI) Sequence A:  MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPAAVP FQQSVITAEIERWPETALTRQLARHPAFVNRDVFPIIADR LTQKQLFDKLHLPTAPWQLLAERSEWPAVFDRLGELAIVK RRTGGYDGRGQWRLRANETEQLPAECYGECIVEQGINFSG EVSLVGARGFDGSTVFYPLTHNLHQDGILRTSVAFPQANA QQQARAEEMLSAIMQELGYVGVMAMECFVTPQGLLINELA PRVHNSGHWTQNGASISQFELHLRAITDLPLPQPVVNNPS VMINLIGSDVNYDWLKLPLVHLHWYDKEVRPGRKVGHLNL TDSDTSRLTATLEALIPLLPPEYASGVIWAQSKFG B:  MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPAAVP FQQSVITAEIERWPETALTRQLARHPAFVNRDVFPIIADR LTQKQLFDKLHLPTAPWQLLAERSEWPAVFDRLGELAIVK RRTGGGQWRLRANETEQLPAECYGECIVEQGINFSGEVSL VGARGFDGSTVFYPLTHNLHQDGILRTSVAFPQANAQQQA RAEEMLSAIMQELGYVGVMAMECFVTPQGLLINELAPRVH NSGHWTQNGASISQFELHLRAITDLPLPQPVVNNPSVMIN LIGSDVNYDWLKLPLVHLHWYDKEVRPGRKVGHLNLTDSD TSRLTATLEALIPLLPPEYASGVIWAQSKFG Description Functional site 1) chain A residue 80 type sequence R description BINDING SITE FOR RESIDUE ADP A 400 source : AC1 2) chain A residue 120 type sequence K description BINDING SITE FOR RESIDUE ADP A 400 source : AC1 3) chain A residue 126 type sequence Y description BINDING SITE FOR RESIDUE ADP A 400 source : AC1 4) chain A residue 127 type sequence D description BINDING SITE FOR RESIDUE ADP A 400 source : AC1 5) chain A residue 128 type sequence G description BINDING SITE FOR RESIDUE ADP A 400 source : AC1 6) chain A residue 131 type sequence Q description BINDING SITE FOR RESIDUE ADP A 400 source : AC1 7) chain A residue 133 type sequence R description BINDING SITE FOR RESIDUE ADP A 400 source : AC1 8) chain A residue 153 type sequence E description BINDING SITE FOR RESIDUE ADP A 400 source : AC1 9) chain A residue 154 type sequence Q description BINDING SITE FOR RESIDUE ADP A 400 source : AC1 10) chain A residue 155 type sequence G description BINDING SITE FOR RESIDUE ADP A 400 source : AC1 11) chain A residue 156 type sequence I description BINDING SITE FOR RESIDUE ADP A 400 source : AC1 12) chain A residue 158 type sequence F description BINDING SITE FOR RESIDUE ADP A 400 source : AC1 13) chain A residue 161 type sequence E description BINDING SITE FOR RESIDUE ADP A 400 source : AC1 14) chain A residue 184 type sequence H description BINDING SITE FOR RESIDUE ADP A 400 source : AC1 15) chain A residue 187 type sequence G description BINDING SITE FOR RESIDUE ADP A 400 source : AC1 16) chain A residue 226 type sequence E description BINDING SITE FOR RESIDUE ADP A 400 source : AC1 17) chain A residue 228 type sequence F description BINDING SITE FOR RESIDUE ADP A 400 source : AC1 18) chain A residue 237 type sequence N description BINDING SITE FOR RESIDUE ADP A 400 source : AC1 19) chain A residue 238 type sequence E description BINDING SITE FOR RESIDUE ADP A 400 source : AC1 20) chain A residue 226 type sequence E description BINDING SITE FOR RESIDUE MG A 401 source : AC2 21) chain A residue 238 type sequence E description BINDING SITE FOR RESIDUE MG A 401 source : AC2 22) chain A residue 238 type sequence E description BINDING SITE FOR RESIDUE MG A 402 source : AC3 23) chain A residue 126 type sequence Y description BINDING SITE FOR RESIDUE PI A 403 source : AC4 24) chain A residue 127 type sequence D description BINDING SITE FOR RESIDUE PI A 403 source : AC4 25) chain A residue 226 type sequence E description BINDING SITE FOR RESIDUE PI A 403 source : AC4 26) chain A residue 238 type sequence E description BINDING SITE FOR RESIDUE PI A 403 source : AC4 27) chain A residue 242 type sequence R description BINDING SITE FOR RESIDUE PI A 403 source : AC4 28) chain A residue 244 type sequence H description BINDING SITE FOR RESIDUE PI A 403 source : AC4 29) chain B residue 80 type sequence R description BINDING SITE FOR RESIDUE ADP B 400 source : AC5 30) chain B residue 118 type sequence I description BINDING SITE FOR RESIDUE ADP B 400 source : AC5 31) chain B residue 120 type sequence K description BINDING SITE FOR RESIDUE ADP B 400 source : AC5 32) chain B residue 131 type sequence Q description BINDING SITE FOR RESIDUE ADP B 400 source : AC5 33) chain B residue 153 type sequence E description BINDING SITE FOR RESIDUE ADP B 400 source : AC5 34) chain B residue 154 type sequence Q description BINDING SITE FOR RESIDUE ADP B 400 source : AC5 35) chain B residue 155 type sequence G description BINDING SITE FOR RESIDUE ADP B 400 source : AC5 36) chain B residue 156 type sequence I description BINDING SITE FOR RESIDUE ADP B 400 source : AC5 37) chain B residue 158 type sequence F description BINDING SITE FOR RESIDUE ADP B 400 source : AC5 38) chain B residue 161 type sequence E description BINDING SITE FOR RESIDUE ADP B 400 source : AC5 39) chain B residue 184 type sequence H description BINDING SITE FOR RESIDUE ADP B 400 source : AC5 40) chain B residue 226 type sequence E description BINDING SITE FOR RESIDUE ADP B 400 source : AC5 41) chain B residue 228 type sequence F description BINDING SITE FOR RESIDUE ADP B 400 source : AC5 42) chain B residue 237 type sequence N description BINDING SITE FOR RESIDUE ADP B 400 source : AC5 43) chain B residue 238 type sequence E description BINDING SITE FOR RESIDUE ADP B 400 source : AC5 44) chain B residue 226 type sequence E description BINDING SITE FOR RESIDUE MG B 401 source : AC6 45) chain B residue 238 type sequence E description BINDING SITE FOR RESIDUE MG B 401 source : AC6 46) chain B residue 238 type sequence E description BINDING SITE FOR RESIDUE MG B 402 source : AC7 47) chain B residue 226 type sequence E description BINDING SITE FOR RESIDUE PI B 403 source : AC8 48) chain B residue 238 type sequence E description BINDING SITE FOR RESIDUE PI B 403 source : AC8 49) chain B residue 242 type sequence R description BINDING SITE FOR RESIDUE PI B 403 source : AC8 50) chain B residue 244 type sequence H description BINDING SITE FOR RESIDUE PI B 403 source : AC8 51) chain A residue 242 type sequence R description BINDING SITE FOR RESIDUE CL A 404 source : AC9 52) chain A residue 243 type sequence V description BINDING SITE FOR RESIDUE CL A 404 source : AC9 53) chain A residue 262 type sequence H description BINDING SITE FOR RESIDUE CL A 404 source : AC9 54) chain A residue 80 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 55) chain B residue 125 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 56) chain B residue 153 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 57) chain B residue 161 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 58) chain B residue 184 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 59) chain B residue 237 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 60) chain A residue 120 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 61) chain A residue 125 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 62) chain A residue 153 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 63) chain A residue 161 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 64) chain A residue 184 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 65) chain A residue 237 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 66) chain B residue 80 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 67) chain B residue 120 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1

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