eF-site ID 3eta-B PDB Code 3eta Chain B click to enlarge Title Kinase domain of insulin receptor complexed with a pyrrolo pyridine inhibitor Classification SIGNALING PROTEIN, TRANSFERASE Compound insulin receptor, kinase domain Source (INSR_HUMAN) Sequence B:  EVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAV KTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKG QPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEM IQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIG DFGMTRDIYETDYYRKKGLLPVRWMAPESLKDGVFTTSSD MWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQP DNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSF PEVSFFHSEENK Description Functional site 1) chain B residue 1002 type sequence L description BINDING SITE FOR RESIDUE 351 B2001 source : AC2 2) chain B residue 1028 type sequence A description BINDING SITE FOR RESIDUE 351 B2001 source : AC2 3) chain B residue 1047 type sequence E description BINDING SITE FOR RESIDUE 351 B2001 source : AC2 4) chain B residue 1050 type sequence V description BINDING SITE FOR RESIDUE 351 B2001 source : AC2 5) chain B residue 1051 type sequence M description BINDING SITE FOR RESIDUE 351 B2001 source : AC2 6) chain B residue 1060 type sequence V description BINDING SITE FOR RESIDUE 351 B2001 source : AC2 7) chain B residue 1076 type sequence M description BINDING SITE FOR RESIDUE 351 B2001 source : AC2 8) chain B residue 1077 type sequence E description BINDING SITE FOR RESIDUE 351 B2001 source : AC2 9) chain B residue 1079 type sequence M description BINDING SITE FOR RESIDUE 351 B2001 source : AC2 10) chain B residue 1082 type sequence G description BINDING SITE FOR RESIDUE 351 B2001 source : AC2 11) chain B residue 1128 type sequence F description BINDING SITE FOR RESIDUE 351 B2001 source : AC2 12) chain B residue 1139 type sequence M description BINDING SITE FOR RESIDUE 351 B2001 source : AC2 13) chain B residue 1148 type sequence I description BINDING SITE FOR RESIDUE 351 B2001 source : AC2 14) chain B residue 1149 type sequence G description BINDING SITE FOR RESIDUE 351 B2001 source : AC2 15) chain B residue 1150 type sequence D description BINDING SITE FOR RESIDUE 351 B2001 source : AC2 16) chain B residue 1132 type ACT_SITE sequence D description Proton donor/acceptor => ECO:0000269|PubMed:9312016 source Swiss-Prot : SWS_FT_FI1 17) chain B residue 1150 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:18278056 source Swiss-Prot : SWS_FT_FI2 18) chain B residue 1006 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:18278056 source Swiss-Prot : SWS_FT_FI2 19) chain B residue 1030 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:18278056 source Swiss-Prot : SWS_FT_FI2 20) chain B residue 1077 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:18278056 source Swiss-Prot : SWS_FT_FI2 21) chain B residue 1136 type BINDING sequence R description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:18278056 source Swiss-Prot : SWS_FT_FI2 22) chain B residue 1158 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:14690593, ECO:0000269|PubMed:16246733, ECO:0000269|PubMed:16271887, ECO:0000269|PubMed:18278056, ECO:0000269|PubMed:18767165, ECO:0000269|PubMed:3166375, ECO:0000269|PubMed:9312016 source Swiss-Prot : SWS_FT_FI3 23) chain B residue 1162 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:14690593, ECO:0000269|PubMed:16246733, ECO:0000269|PubMed:16271887, ECO:0000269|PubMed:18278056, ECO:0000269|PubMed:18767165, ECO:0000269|PubMed:3166375, ECO:0000269|PubMed:9312016 source Swiss-Prot : SWS_FT_FI3 24) chain B residue 1163 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:14690593, ECO:0000269|PubMed:16246733, ECO:0000269|PubMed:16271887, ECO:0000269|PubMed:18278056, ECO:0000269|PubMed:18767165, ECO:0000269|PubMed:3166375, ECO:0000269|PubMed:9312016 source Swiss-Prot : SWS_FT_FI3 25) chain B residue 1132 type catalytic sequence D description 246 source MCSA : MCSA2 26) chain B residue 1136 type catalytic sequence R description 246 source MCSA : MCSA2 27) chain B residue 1137 type catalytic sequence N description 246 source MCSA : MCSA2 28) chain B residue 1150 type catalytic sequence D description 246 source MCSA : MCSA2

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