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eF-site ID
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3eql-C |
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PDB Code
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3eql |
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Chain
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C |
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click to enlarge
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Title
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Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic myxopyronin |
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Classification
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TRANSFERASE |
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Compound
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DNA-directed RNA polymerase subunit alpha |
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Source
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ORGANISM_SCIENTIFIC: Thermus thermophilus; |
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Sequence
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C: |
MEIKRFGRIREVIPLPPLTEIQVESYRRALQADVPPEKRE
NVGIQAAFRETFPIEEEDKGKGGLVLDFLEYRLGEPPFPQ
DECREKDLTYQAPLYARLQLIHKDTGLIKEDEVFLGHIPL
MTEDGSFIINGADRVIVSQIHRSPGVYFTPDPARPGRYIA
SIIPLPKRGPWIDLEVEPNGVVSMKVNKRKFPLVLLLRVL
GYDQETLARELGAYGELVQGLMDESVFAMRPEEALIRLFT
LLRPGDPPKRDKAVAYVYGLIADPRRYDLGEAGRYKAEEK
LGIRLSGRTLARFEDGEFKDEVFLPTLRYLFALTAGVPGH
EVDDIDHLGNRRIRTVGELMTDQFRVGLARLARGVRERML
MGSEDSLTPAKLVNSRPLEAAIREFFSRSQLSQFKDETNP
LSSLRHKRRISALGPGGLTRERAGFDVRDVHRTHYGRICP
VETPEGANIGLITSLAAYARVDELGFIRTPYRRVVGGVVT
DEVVYMTATEEDRYTIAQANTPLEGNRIAAERVVARRKGE
PVIVSPEEVEFMDVSPKQVFSVNTNLIPFLEHDDANRALM
GSNMQTQAVPLIRAQAPVVMTGLEERVVRDSLAALYAEED
GEVAKVDGNRIVVRYEDGRLVEYPLRRFYRSNQGTALDQR
PRVVVGQRVRKGDLLADGPASENGFLALGQNVLVAIMPFD
GYNFEDAIVISEELLKRDFYTSIHIERYEIEARDTKLGPE
RITRDIPHLSEAALRDLDEEGVVRIGAEVKPGDILVGRTS
FKGESEPTPEERLLRSIFGEKARDVKDTSLRVPPGEGGIV
VRTVRLRRGDPGVELKPGVREVVRVYVAQKRKLQVGDKLA
NRHGNKGVVAKILPVEDMPHLPDGTPVDVILNPLGVPSRM
NLGQILETHLGLAGYFLGQRYISPIFDGAKEPEIKELLAQ
AFEVYFGKRKGEGFGVDKREVEVLRRAEKLGLVTPGKTPE
EQLKELFLQGKVVLYDGRTGEPIEGPIVVGQMFIMKLYHM
VEDKMHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWAL
EAYGAAHTLQEMLTLKSDDIEGRNAAYEAIIKGEDVPEPS
VPESFRVLVKELQALALDVQTLDEKDNPVDIFEGLASKR
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Description
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Functional site
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1)
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chain |
C |
| residue |
1034 |
| type |
|
| sequence |
E
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| description |
BINDING SITE FOR RESIDUE MXP D1527
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| source |
: AC3
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2)
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chain |
C |
| residue |
1038 |
| type |
|
| sequence |
W
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| description |
BINDING SITE FOR RESIDUE MXP D1527
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| source |
: AC3
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3)
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chain |
C |
| residue |
1041 |
| type |
|
| sequence |
E
|
| description |
BINDING SITE FOR RESIDUE MXP D1527
|
| source |
: AC3
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|
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4)
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chain |
C |
| residue |
1084 |
| type |
|
| sequence |
S
|
| description |
BINDING SITE FOR RESIDUE MXP D1527
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| source |
: AC3
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|
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5)
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chain |
C |
| residue |
1088 |
| type |
|
| sequence |
L
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| description |
BINDING SITE FOR RESIDUE MXP D1527
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| source |
: AC3
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6)
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chain |
C |
| residue |
836-848 |
| type |
prosite |
| sequence |
GDKLANRHGNKGV
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| description |
RNA_POL_BETA RNA polymerases beta chain signature. GdKLANrHGNKGV
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| source |
prosite : PS01166
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