eF-site ID 3eq1-AB
PDB Code 3eq1
Chain A, B

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Title The Crystal Structure of Human Porphobilinogen Deaminase at 2.8A resolution
Classification TRANSFERASE
Compound Porphobilinogen deaminase
Source Homo sapiens (Human) (HEM3_HUMAN)
Sequence A:  RVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAFTK
ELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENP
HDAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFP
HLEFRSIQGNLNTRLRKLDEQQEFSAIILATAGLQRMGWH
NRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLH
DPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLT
GGVWSLDGSDSIQETMQATIHVPQHEDDPQLVGITARNIP
RGPQLAAQNLGISLANLLLSKGAKNILDVARQ
B:  RVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAFTK
ELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENP
HDAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFP
HLEFRSIQGNLNTRLRKLDEQQEFSAIILATAGLQRMGWH
NRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLH
DPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLT
GGVWSLDGSDSIQETMQATIHVPQHEDDPQLVGITARNIP
RGPQLAAQNLGISLANLLLSKGAKNILDVARQ
Description


Functional site

1) chain A
residue 96
type
sequence S
description BINDING SITE FOR RESIDUE DPM A 400
source : AC1

2) chain A
residue 98
type
sequence K
description BINDING SITE FOR RESIDUE DPM A 400
source : AC1

3) chain A
residue 99
type
sequence D
description BINDING SITE FOR RESIDUE DPM A 400
source : AC1

4) chain A
residue 146
type
sequence S
description BINDING SITE FOR RESIDUE DPM A 400
source : AC1

5) chain A
residue 147
type
sequence S
description BINDING SITE FOR RESIDUE DPM A 400
source : AC1

6) chain A
residue 149
type
sequence R
description BINDING SITE FOR RESIDUE DPM A 400
source : AC1

7) chain A
residue 150
type
sequence R
description BINDING SITE FOR RESIDUE DPM A 400
source : AC1

8) chain A
residue 173
type
sequence R
description BINDING SITE FOR RESIDUE DPM A 400
source : AC1

9) chain A
residue 188
type
sequence L
description BINDING SITE FOR RESIDUE DPM A 400
source : AC1

10) chain A
residue 189
type
sequence A
description BINDING SITE FOR RESIDUE DPM A 400
source : AC1

11) chain A
residue 195
type
sequence R
description BINDING SITE FOR RESIDUE DPM A 400
source : AC1

12) chain A
residue 214
type
sequence A
description BINDING SITE FOR RESIDUE DPM A 400
source : AC1

13) chain A
residue 218
type
sequence G
description BINDING SITE FOR RESIDUE DPM A 400
source : AC1

14) chain A
residue 261
type
sequence C
description BINDING SITE FOR RESIDUE DPM A 400
source : AC1

15) chain B
residue 96
type
sequence S
description BINDING SITE FOR RESIDUE DPM B 401
source : AC2

16) chain B
residue 98
type
sequence K
description BINDING SITE FOR RESIDUE DPM B 401
source : AC2

17) chain B
residue 99
type
sequence D
description BINDING SITE FOR RESIDUE DPM B 401
source : AC2

18) chain B
residue 146
type
sequence S
description BINDING SITE FOR RESIDUE DPM B 401
source : AC2

19) chain B
residue 147
type
sequence S
description BINDING SITE FOR RESIDUE DPM B 401
source : AC2

20) chain B
residue 149
type
sequence R
description BINDING SITE FOR RESIDUE DPM B 401
source : AC2

21) chain B
residue 150
type
sequence R
description BINDING SITE FOR RESIDUE DPM B 401
source : AC2

22) chain B
residue 173
type
sequence R
description BINDING SITE FOR RESIDUE DPM B 401
source : AC2

23) chain B
residue 188
type
sequence L
description BINDING SITE FOR RESIDUE DPM B 401
source : AC2

24) chain B
residue 189
type
sequence A
description BINDING SITE FOR RESIDUE DPM B 401
source : AC2

25) chain B
residue 195
type
sequence R
description BINDING SITE FOR RESIDUE DPM B 401
source : AC2

26) chain B
residue 218
type
sequence G
description BINDING SITE FOR RESIDUE DPM B 401
source : AC2

27) chain B
residue 261
type
sequence C
description BINDING SITE FOR RESIDUE DPM B 401
source : AC2

28) chain A
residue 26
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 362
source : AC3

29) chain A
residue 28
type
sequence S
description BINDING SITE FOR RESIDUE SO4 A 362
source : AC3

30) chain A
residue 30
type
sequence L
description BINDING SITE FOR RESIDUE SO4 A 362
source : AC3

31) chain A
residue 31
type
sequence A
description BINDING SITE FOR RESIDUE SO4 A 362
source : AC3

32) chain A
residue 169
type
sequence N
description BINDING SITE FOR RESIDUE SO4 A 362
source : AC3

33) chain A
residue 120
type
sequence H
description BINDING SITE FOR RESIDUE SO4 A 363
source : AC4

34) chain A
residue 208
type
sequence P
description BINDING SITE FOR RESIDUE SO4 A 363
source : AC4

35) chain A
residue 268
type
sequence H
description BINDING SITE FOR RESIDUE SO4 A 363
source : AC4

36) chain A
residue 119
type
sequence P
description BINDING SITE FOR RESIDUE SO4 A 364
source : AC5

37) chain A
residue 246
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 364
source : AC5

38) chain B
residue 26
type
sequence R
description BINDING SITE FOR RESIDUE SO4 B 362
source : AC6

39) chain B
residue 28
type
sequence S
description BINDING SITE FOR RESIDUE SO4 B 362
source : AC6

40) chain B
residue 169
type
sequence N
description BINDING SITE FOR RESIDUE SO4 B 362
source : AC6

41) chain B
residue 120
type
sequence H
description BINDING SITE FOR RESIDUE SO4 B 363
source : AC7

42) chain B
residue 207
type
sequence H
description BINDING SITE FOR RESIDUE SO4 B 363
source : AC7

43) chain B
residue 208
type
sequence P
description BINDING SITE FOR RESIDUE SO4 B 363
source : AC7

44) chain B
residue 268
type
sequence H
description BINDING SITE FOR RESIDUE SO4 B 363
source : AC7

45) chain B
residue 119
type
sequence P
description BINDING SITE FOR RESIDUE SO4 B 364
source : AC8

46) chain B
residue 246
type
sequence R
description BINDING SITE FOR RESIDUE SO4 B 364
source : AC8

47) chain A
residue 250-266
type prosite
sequence ERAFLRHLEGGCSVPVA
description PORPHOBILINOGEN_DEAM Porphobilinogen deaminase cofactor-binding site. ERaFlrhLeGGCsVPVA
source prosite : PS00533

48) chain A
residue 147
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI2

49) chain B
residue 147
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI2

50) chain A
residue 261
type MOD_RES
sequence C
description S-(dipyrrolylmethanemethyl)cysteine => ECO:0000269|PubMed:18936296
source Swiss-Prot : SWS_FT_FI4

51) chain B
residue 261
type MOD_RES
sequence C
description S-(dipyrrolylmethanemethyl)cysteine => ECO:0000269|PubMed:18936296
source Swiss-Prot : SWS_FT_FI4


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