eF-site ID 3eq1-AB PDB Code 3eq1 Chain A, B click to enlarge Title The Crystal Structure of Human Porphobilinogen Deaminase at 2.8A resolution Classification TRANSFERASE Compound Porphobilinogen deaminase Source Homo sapiens (Human) (HEM3_HUMAN) Sequence A:  RVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAFTK ELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENP HDAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFP HLEFRSIQGNLNTRLRKLDEQQEFSAIILATAGLQRMGWH NRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLH DPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLT GGVWSLDGSDSIQETMQATIHVPQHEDDPQLVGITARNIP RGPQLAAQNLGISLANLLLSKGAKNILDVARQ B:  RVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAFTK ELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENP HDAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFP HLEFRSIQGNLNTRLRKLDEQQEFSAIILATAGLQRMGWH NRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLH DPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLT GGVWSLDGSDSIQETMQATIHVPQHEDDPQLVGITARNIP RGPQLAAQNLGISLANLLLSKGAKNILDVARQ Description Functional site 1) chain A residue 96 type sequence S description BINDING SITE FOR RESIDUE DPM A 400 source : AC1 2) chain A residue 98 type sequence K description BINDING SITE FOR RESIDUE DPM A 400 source : AC1 3) chain A residue 99 type sequence D description BINDING SITE FOR RESIDUE DPM A 400 source : AC1 4) chain A residue 146 type sequence S description BINDING SITE FOR RESIDUE DPM A 400 source : AC1 5) chain A residue 147 type sequence S description BINDING SITE FOR RESIDUE DPM A 400 source : AC1 6) chain A residue 149 type sequence R description BINDING SITE FOR RESIDUE DPM A 400 source : AC1 7) chain A residue 150 type sequence R description BINDING SITE FOR RESIDUE DPM A 400 source : AC1 8) chain A residue 173 type sequence R description BINDING SITE FOR RESIDUE DPM A 400 source : AC1 9) chain A residue 188 type sequence L description BINDING SITE FOR RESIDUE DPM A 400 source : AC1 10) chain A residue 189 type sequence A description BINDING SITE FOR RESIDUE DPM A 400 source : AC1 11) chain A residue 195 type sequence R description BINDING SITE FOR RESIDUE DPM A 400 source : AC1 12) chain A residue 214 type sequence A description BINDING SITE FOR RESIDUE DPM A 400 source : AC1 13) chain A residue 218 type sequence G description BINDING SITE FOR RESIDUE DPM A 400 source : AC1 14) chain A residue 261 type sequence C description BINDING SITE FOR RESIDUE DPM A 400 source : AC1 15) chain B residue 96 type sequence S description BINDING SITE FOR RESIDUE DPM B 401 source : AC2 16) chain B residue 98 type sequence K description BINDING SITE FOR RESIDUE DPM B 401 source : AC2 17) chain B residue 99 type sequence D description BINDING SITE FOR RESIDUE DPM B 401 source : AC2 18) chain B residue 146 type sequence S description BINDING SITE FOR RESIDUE DPM B 401 source : AC2 19) chain B residue 147 type sequence S description BINDING SITE FOR RESIDUE DPM B 401 source : AC2 20) chain B residue 149 type sequence R description BINDING SITE FOR RESIDUE DPM B 401 source : AC2 21) chain B residue 150 type sequence R description BINDING SITE FOR RESIDUE DPM B 401 source : AC2 22) chain B residue 173 type sequence R description BINDING SITE FOR RESIDUE DPM B 401 source : AC2 23) chain B residue 188 type sequence L description BINDING SITE FOR RESIDUE DPM B 401 source : AC2 24) chain B residue 189 type sequence A description BINDING SITE FOR RESIDUE DPM B 401 source : AC2 25) chain B residue 195 type sequence R description BINDING SITE FOR RESIDUE DPM B 401 source : AC2 26) chain B residue 218 type sequence G description BINDING SITE FOR RESIDUE DPM B 401 source : AC2 27) chain B residue 261 type sequence C description BINDING SITE FOR RESIDUE DPM B 401 source : AC2 28) chain A residue 26 type sequence R description BINDING SITE FOR RESIDUE SO4 A 362 source : AC3 29) chain A residue 28 type sequence S description BINDING SITE FOR RESIDUE SO4 A 362 source : AC3 30) chain A residue 30 type sequence L description BINDING SITE FOR RESIDUE SO4 A 362 source : AC3 31) chain A residue 31 type sequence A description BINDING SITE FOR RESIDUE SO4 A 362 source : AC3 32) chain A residue 169 type sequence N description BINDING SITE FOR RESIDUE SO4 A 362 source : AC3 33) chain A residue 120 type sequence H description BINDING SITE FOR RESIDUE SO4 A 363 source : AC4 34) chain A residue 208 type sequence P description BINDING SITE FOR RESIDUE SO4 A 363 source : AC4 35) chain A residue 268 type sequence H description BINDING SITE FOR RESIDUE SO4 A 363 source : AC4 36) chain A residue 119 type sequence P description BINDING SITE FOR RESIDUE SO4 A 364 source : AC5 37) chain A residue 246 type sequence R description BINDING SITE FOR RESIDUE SO4 A 364 source : AC5 38) chain B residue 26 type sequence R description BINDING SITE FOR RESIDUE SO4 B 362 source : AC6 39) chain B residue 28 type sequence S description BINDING SITE FOR RESIDUE SO4 B 362 source : AC6 40) chain B residue 169 type sequence N description BINDING SITE FOR RESIDUE SO4 B 362 source : AC6 41) chain B residue 120 type sequence H description BINDING SITE FOR RESIDUE SO4 B 363 source : AC7 42) chain B residue 207 type sequence H description BINDING SITE FOR RESIDUE SO4 B 363 source : AC7 43) chain B residue 208 type sequence P description BINDING SITE FOR RESIDUE SO4 B 363 source : AC7 44) chain B residue 268 type sequence H description BINDING SITE FOR RESIDUE SO4 B 363 source : AC7 45) chain B residue 119 type sequence P description BINDING SITE FOR RESIDUE SO4 B 364 source : AC8 46) chain B residue 246 type sequence R description BINDING SITE FOR RESIDUE SO4 B 364 source : AC8 47) chain A residue 250-266 type prosite sequence ERAFLRHLEGGCSVPVA description PORPHOBILINOGEN_DEAM Porphobilinogen deaminase cofactor-binding site. ERaFlrhLeGGCsVPVA source prosite : PS00533 48) chain A residue 147 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 49) chain B residue 147 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 50) chain A residue 261 type MOD_RES sequence C description S-(dipyrrolylmethanemethyl)cysteine => ECO:0000269|PubMed:18936296 source Swiss-Prot : SWS_FT_FI4 51) chain B residue 261 type MOD_RES sequence C description S-(dipyrrolylmethanemethyl)cysteine => ECO:0000269|PubMed:18936296 source Swiss-Prot : SWS_FT_FI4

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