eF-site ID 3eov-A PDB Code 3eov Chain A click to enlarge Title Crystal structure of cyclophilin from Leishmania donovani ligated with cyclosporin A Classification ISOMERASE/IMMUNOSUPPRESSANT Compound PEPTIDYL-PROLYL CIS-TRANS ISOMERASE Source Leishmania donovani (NOR00033) Sequence A:  EPEVTAKVYFDVMIDSEPLGRITIGLFGKDAPLTTENFRQ LCTGEHGFGYKDSIFHRVIQNFMIQGGDFTNFDGTGGKSI YGEKFADENLNVKHFVGALSMANAGPNTNGSQFFITTAPT PWLDGRHVVFGKVLDGMDVVLRIEKTKTNSHDRPVKPVKI VASGEL Description Functional site 1) chain A residue 78 type sequence R description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 2) chain A residue 83 type sequence F description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 3) chain A residue 86 type sequence Q description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 4) chain A residue 95 type sequence G description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 5) chain A residue 123 type sequence A description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 6) chain A residue 124 type sequence N description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 7) chain A residue 133 type sequence Q description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 8) chain A residue 143 type sequence W description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 9) chain A residue 148 type sequence H description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 10) chain A residue 127 type sequence P description BINDING SITE FOR CHAIN D OF CYCLOSPORIN A source : AC2 11) chain A residue 143 type sequence W description BINDING SITE FOR CHAIN D OF CYCLOSPORIN A source : AC2 12) chain A residue 147 type sequence R description BINDING SITE FOR CHAIN D OF CYCLOSPORIN A source : AC2 13) chain A residue 71-88 type prosite sequence YKDSIFHRVIQNFMIQGG description CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkdSiFHRVIqnFMiQGG source prosite : PS00170

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