eF-site ID 3em6-B PDB Code 3em6 Chain B Title Crystal structure of I50L/A71V mutant of hiv-1 protease in complex with inhibitor darunavir Classification HYDROLASE Compound Protease Source Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) (POL_HV1A2) Sequence B:  PQITLWKRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPG KWKPKMIGGLGGFIKVRQYDQIPVEICGHKVIGTVLVGPT PVNIIGRNLLTQIGCTLNF Description Functional site 1) chain B residue 25 type sequence D description BINDING SITE FOR RESIDUE 017 A 200 source : AC1 2) chain B residue 27 type sequence G description BINDING SITE FOR RESIDUE 017 A 200 source : AC1 3) chain B residue 28 type sequence A description BINDING SITE FOR RESIDUE 017 A 200 source : AC1 4) chain B residue 30 type sequence D description BINDING SITE FOR RESIDUE 017 A 200 source : AC1 5) chain B residue 48 type sequence G description BINDING SITE FOR RESIDUE 017 A 200 source : AC1 6) chain B residue 49 type sequence G description BINDING SITE FOR RESIDUE 017 A 200 source : AC1 7) chain B residue 81 type sequence P description BINDING SITE FOR RESIDUE 017 A 200 source : AC1 8) chain B residue 39 type sequence P description BINDING SITE FOR RESIDUE PO4 A 504 source : AC3 9) chain B residue 40 type sequence G description BINDING SITE FOR RESIDUE PO4 A 504 source : AC3 10) chain B residue 16 type sequence G description BINDING SITE FOR RESIDUE ACT A 606 source : AC5 11) chain B residue 1 type sequence P description BINDING SITE FOR RESIDUE PO4 B 503 source : AC6 12) chain B residue 6 type sequence W description BINDING SITE FOR RESIDUE PO4 B 506 source : AC7 13) chain B residue 7 type sequence K description BINDING SITE FOR RESIDUE PO4 B 506 source : AC7 14) chain B residue 8 type sequence R description BINDING SITE FOR RESIDUE PO4 B 506 source : AC7 15) chain B residue 73 type sequence G description BINDING SITE FOR RESIDUE ACT B 603 source : AC8 16) chain B residue 74 type sequence T description BINDING SITE FOR RESIDUE ACT B 603 source : AC8 17) chain B residue 88 type sequence N description BINDING SITE FOR RESIDUE ACT B 603 source : AC8 18) chain B residue 92 type sequence Q description BINDING SITE FOR RESIDUE ACT B 603 source : AC8 19) chain B residue 20 type sequence K description BINDING SITE FOR RESIDUE ACT B 605 source : AC9 20) chain B residue 21 type sequence E description BINDING SITE FOR RESIDUE ACT B 605 source : AC9 21) chain B residue 83 type sequence N description BINDING SITE FOR RESIDUE ACT B 605 source : AC9 22) chain B residue 25 type ACT_SITE sequence D description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1 23) chain B residue 99 type SITE sequence F description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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