eF-site ID 3em6-A PDB Code 3em6 Chain A click to enlarge Title Crystal structure of I50L/A71V mutant of hiv-1 protease in complex with inhibitor darunavir Classification HYDROLASE Compound Protease Source Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) (POL_HV1A2) Sequence A:  PQITLWKRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPG KWKPKMIGGLGGFIKVRQYDQIPVEICGHKVIGTVLVGPT PVNIIGRNLLTQIGCTLNF Description Functional site 1) chain A residue 25 type sequence D description BINDING SITE FOR RESIDUE 017 A 200 source : AC1 2) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE 017 A 200 source : AC1 3) chain A residue 28 type sequence A description BINDING SITE FOR RESIDUE 017 A 200 source : AC1 4) chain A residue 29 type sequence D description BINDING SITE FOR RESIDUE 017 A 200 source : AC1 5) chain A residue 30 type sequence D description BINDING SITE FOR RESIDUE 017 A 200 source : AC1 6) chain A residue 48 type sequence G description BINDING SITE FOR RESIDUE 017 A 200 source : AC1 7) chain A residue 49 type sequence G description BINDING SITE FOR RESIDUE 017 A 200 source : AC1 8) chain A residue 50 type sequence L description BINDING SITE FOR RESIDUE 017 A 200 source : AC1 9) chain A residue 7 type sequence K description BINDING SITE FOR RESIDUE PO4 A 502 source : AC2 10) chain A residue 8 type sequence R description BINDING SITE FOR RESIDUE PO4 A 502 source : AC2 11) chain A residue 36 type sequence M description BINDING SITE FOR RESIDUE PO4 A 504 source : AC3 12) chain A residue 37 type sequence N description BINDING SITE FOR RESIDUE PO4 A 504 source : AC3 13) chain A residue 20 type sequence K description BINDING SITE FOR RESIDUE PO4 A 505 source : AC4 14) chain A residue 21 type sequence E description BINDING SITE FOR RESIDUE PO4 A 505 source : AC4 15) chain A residue 83 type sequence N description BINDING SITE FOR RESIDUE PO4 A 505 source : AC4 16) chain A residue 14 type sequence R description BINDING SITE FOR RESIDUE ACT A 606 source : AC5 17) chain A residue 16 type sequence G description BINDING SITE FOR RESIDUE ACT A 606 source : AC5 18) chain A residue 17 type sequence G description BINDING SITE FOR RESIDUE ACT A 606 source : AC5 19) chain A residue 69 type sequence H description BINDING SITE FOR RESIDUE PO4 B 503 source : AC6 20) chain A residue 70 type sequence K description BINDING SITE FOR RESIDUE PO4 B 503 source : AC6 21) chain A residue 87 type sequence R description BINDING SITE FOR RESIDUE PO4 B 506 source : AC7 22) chain A residue 25 type ACT_SITE sequence D description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 99 type SITE sequence F description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 24) chain A residue 22-33 type prosite sequence ALLDTGADDTVL description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL source prosite : PS00141

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