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eF-site ID
|
3ejp-A |
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PDB Code
|
3ejp |
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Chain
|
A |
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click to enlarge
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Title
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Golgi alpha-Mannosidase II in complex with 5-substituted swainsonine analog: (5R)-5-[2'-oxo-2'-(phenyl)ethyl]-swainsonine |
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Classification
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HYDROLASE |
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Compound
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Alpha-mannosidase 2 |
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Source
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(MAN2_DROME) |
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Sequence
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A: |
QCQDVVQDVPNVDVQMLELYDRMSFKDIDGGVWKQGWNIK
YDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQHDTKH
ILSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQM
KSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWL
KQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRT
HYSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSY
DIPHTCGPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQ
NVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTE
WDVQRVNYERLFEHINSQAHFNVQAQFGTLQEYFDAVHQA
ERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMD
RVLMHYVRAAEMLSAWHSWDGMARIEERLEQARRELSLFQ
HHDGITGTAKTHVVVDYEQRMQEALKACQMVMQQSVYRLL
TKPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDI
LPSKHVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPVE
AQVSPVWSWHHDTLTKTIHPQGSTTKYRIIFKARVPPMGL
ATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDVK
FGDPREISLRVGNGPTLAFSEQGLLKSIQLTQDSPHVPVH
FKFLKYGVRSHGDRSGAYLFLPNGPASPVELGQPVVLVTK
GKLESSVSVGLPSVVHQTIMRGGAPEIRNLVDIGSLDNTE
IVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYY
PIPSGMFIEDANTRLTLLTGQPLGGSSLASGELEIMQDRR
LASDDERGLGQGVLDNKPVLHIYRLVLEKVNNCVRPSKLH
PAGYLTSAAHKASQSLLDPLDKFIFAENEWIGAQGQFGGD
HPSAREDLDVSVMRRLTKSSAKTQRVGYVLHRTNLMQCGT
PEEHTQKLDVCHLLPNVARCERTTLTFLQNLEHLDGMVAP
EVCPMETAAYVSSHSS
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Description
|
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Functional site
|
|
|
1)
|
chain |
A |
| residue |
204 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Nucleophile => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
A |
| residue |
90 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
A |
| residue |
92 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
A |
| residue |
204 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
A |
| residue |
471 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
6)
|
chain |
A |
| residue |
90 |
| type |
catalytic |
| sequence |
H
|
| description |
793
|
| source |
MCSA : MCSA1
|
|
|
7)
|
chain |
A |
| residue |
92 |
| type |
catalytic |
| sequence |
D
|
| description |
793
|
| source |
MCSA : MCSA1
|
|
|
8)
|
chain |
A |
| residue |
204 |
| type |
catalytic |
| sequence |
D
|
| description |
793
|
| source |
MCSA : MCSA1
|
|
|
9)
|
chain |
A |
| residue |
341 |
| type |
catalytic |
| sequence |
D
|
| description |
793
|
| source |
MCSA : MCSA1
|
|
|
10)
|
chain |
A |
| residue |
471 |
| type |
catalytic |
| sequence |
H
|
| description |
793
|
| source |
MCSA : MCSA1
|
|
|
|