eF-site ID 3eh0-A
PDB Code 3eh0
Chain A

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Title Crystal Structure of LpxD from Escherichia coli
Classification TRANSFERASE
Compound UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
Source Escherichia coli (strain K12) (LPXD_ECOLI)
Sequence A:  MASIRLADLAQQLDAELHGDGDIVITGVASMQSAQTGHIT
FMVNPKYREHLGLCQASAVVMTQDDLPFAKSAALVVKNPY
LTYARMAQILDTTPQPAQNIAPSAVIDATAKLGNNVSIGA
NAVIESGVELGDNVIIGAGCFVGKNSKIGAGSRLWANVTI
YHEIQIGQNCLIQSGTVVGADGFGYANDRGNWVKIPQIGR
VIIGDRVEIGACTTIDRGALDDTIIGNGVIIDNQCQIAHN
VVIGDNTAVAGGVIMAGSLKIGRYCMIGGASVINGHMEIC
DKVTVTGMGMVMRPITEPGVYSSGIPLQPNKVWRKTAALV
MNIDDMSKRLKSLERKVNQQD
Description


Functional site

1) chain A
residue 100-128
type prosite
sequence IAPSAVIDATAKLGNNVSIGANAVIESGV
description HEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IApsAvIdatAkLGnnVsIGanAvIesgV
source prosite : PS00101

2) chain A
residue 106-134
type prosite
sequence IDATAKLGNNVSIGANAVIESGVELGDNV
description HEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IApsAvIdatAkLGnnVsIGanAvIesgV
source prosite : PS00101

3) chain A
residue 130-158
type prosite
sequence LGDNVIIGAGCFVGKNSKIGAGSRLWANV
description HEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IApsAvIdatAkLGnnVsIGanAvIesgV
source prosite : PS00101

4) chain A
residue 225-253
type prosite
sequence IGNGVIIDNQCQIAHNVVIGDNTAVAGGV
description HEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IApsAvIdatAkLGnnVsIGanAvIesgV
source prosite : PS00101

5) chain A
residue 239
type ACT_SITE
sequence H
description Proton acceptor => ECO:0000269|PubMed:18422345
source Swiss-Prot : SWS_FT_FI1

6) chain A
residue 290
type SITE
sequence M
description Involved in determining the hydroxyacyl-ACP selectivity
source Swiss-Prot : SWS_FT_FI2


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