|
|
eF-site ID
|
3eg1-A |
|
PDB Code
|
3eg1 |
|
Chain
|
A |
|
click to enlarge
|
|
|
Title
|
Crystal structure of the N114Q mutant of ABL-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions |
|
Classification
|
Transferase/Signaling protein |
|
Compound
|
Proto-oncogene tyrosine-protein kinase ABL1 |
|
Source
|
Homo sapiens (Human) (3EG1) |
|
|
Sequence
|
A: |
NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQ
TKNGQGWVPSQYITPVNS
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
110 |
| type |
|
| sequence |
W
|
| description |
BINDING SITE FOR RESIDUE ACE C 0
|
| source |
: AC1
|
|
|
2)
|
chain |
A |
| residue |
103 |
| type |
|
| sequence |
Q
|
| description |
BINDING SITE FOR RESIDUE ACE D 0
|
| source |
: AC2
|
|
|
3)
|
chain |
A |
| residue |
94 |
| type |
|
| sequence |
N
|
| description |
BINDING SITE FOR RESIDUE SO4 A 2
|
| source |
: AC3
|
|
|
4)
|
chain |
A |
| residue |
95 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE SO4 A 2
|
| source |
: AC3
|
|
|
5)
|
chain |
A |
| residue |
70 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16912036, ECO:0000269|PubMed:18775435
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
6)
|
chain |
A |
| residue |
115 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine => ECO:0000269|PubMed:16912036
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|