eF-site ID 3efj-B PDB Code 3efj Chain B click to enlarge Title Structure of c-Met with pyrimidone inhibitor 7 Classification TRANSFERASE Compound Hepatocyte growth factor receptor Source Homo sapiens (Human) (MET_HUMAN) Sequence B:  DLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVY HGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKD FSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNET HNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD EKFTVKVADPVKWMALESLQTQKFTTKSDVWSFGVLLWEL MTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM LKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVH Description Functional site 1) chain B residue 1084 type sequence I description BINDING SITE FOR RESIDUE MT3 B 2 source : AC2 2) chain B residue 1089 type sequence F description BINDING SITE FOR RESIDUE MT3 B 2 source : AC2 3) chain B residue 1092 type sequence V description BINDING SITE FOR RESIDUE MT3 B 2 source : AC2 4) chain B residue 1108 type sequence A description BINDING SITE FOR RESIDUE MT3 B 2 source : AC2 5) chain B residue 1110 type sequence K description BINDING SITE FOR RESIDUE MT3 B 2 source : AC2 6) chain B residue 1124 type sequence F description BINDING SITE FOR RESIDUE MT3 B 2 source : AC2 7) chain B residue 1131 type sequence M description BINDING SITE FOR RESIDUE MT3 B 2 source : AC2 8) chain B residue 1140 type sequence L description BINDING SITE FOR RESIDUE MT3 B 2 source : AC2 9) chain B residue 1157 type sequence L description BINDING SITE FOR RESIDUE MT3 B 2 source : AC2 10) chain B residue 1158 type sequence P description BINDING SITE FOR RESIDUE MT3 B 2 source : AC2 11) chain B residue 1159 type sequence Y description BINDING SITE FOR RESIDUE MT3 B 2 source : AC2 12) chain B residue 1160 type sequence M description BINDING SITE FOR RESIDUE MT3 B 2 source : AC2 13) chain B residue 1163 type sequence G description BINDING SITE FOR RESIDUE MT3 B 2 source : AC2 14) chain B residue 1211 type sequence M description BINDING SITE FOR RESIDUE MT3 B 2 source : AC2 15) chain B residue 1204 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 1084 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 17) chain B residue 1289 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI7 18) chain B residue 1349 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:12475979, ECO:0000269|PubMed:7513258 source Swiss-Prot : SWS_FT_FI8 19) chain B residue 1110 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

Display surface Download Links