eF-site ID 3efj-A PDB Code 3efj Chain A click to enlarge Title Structure of c-Met with pyrimidone inhibitor 7 Classification TRANSFERASE Compound Hepatocyte growth factor receptor Source Homo sapiens (Human) (MET_HUMAN) Sequence A:  DLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVY HGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKD FSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNET HNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD EKFTVKVADFPVKWMALESLQTQKFTTKSDVWSFGVLLWE LMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEV MLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVH Description Functional site 1) chain A residue 1084 type sequence I description BINDING SITE FOR RESIDUE MT3 A 1 source : AC1 2) chain A residue 1089 type sequence F description BINDING SITE FOR RESIDUE MT3 A 1 source : AC1 3) chain A residue 1092 type sequence V description BINDING SITE FOR RESIDUE MT3 A 1 source : AC1 4) chain A residue 1108 type sequence A description BINDING SITE FOR RESIDUE MT3 A 1 source : AC1 5) chain A residue 1110 type sequence K description BINDING SITE FOR RESIDUE MT3 A 1 source : AC1 6) chain A residue 1124 type sequence F description BINDING SITE FOR RESIDUE MT3 A 1 source : AC1 7) chain A residue 1127 type sequence E description BINDING SITE FOR RESIDUE MT3 A 1 source : AC1 8) chain A residue 1128 type sequence G description BINDING SITE FOR RESIDUE MT3 A 1 source : AC1 9) chain A residue 1131 type sequence M description BINDING SITE FOR RESIDUE MT3 A 1 source : AC1 10) chain A residue 1157 type sequence L description BINDING SITE FOR RESIDUE MT3 A 1 source : AC1 11) chain A residue 1158 type sequence P description BINDING SITE FOR RESIDUE MT3 A 1 source : AC1 12) chain A residue 1159 type sequence Y description BINDING SITE FOR RESIDUE MT3 A 1 source : AC1 13) chain A residue 1160 type sequence M description BINDING SITE FOR RESIDUE MT3 A 1 source : AC1 14) chain A residue 1163 type sequence G description BINDING SITE FOR RESIDUE MT3 A 1 source : AC1 15) chain A residue 1211 type sequence M description BINDING SITE FOR RESIDUE MT3 A 1 source : AC1 16) chain A residue 1223 type sequence F description BINDING SITE FOR RESIDUE MT3 A 1 source : AC1 17) chain A residue 1204 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 1084 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 1289 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI7 20) chain A residue 1349 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:12475979, ECO:0000269|PubMed:7513258 source Swiss-Prot : SWS_FT_FI8 21) chain A residue 1084-1110 type prosite sequence IGRGHFGCVYHGTLLDNDGKKIHCAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGHFGCVYhGtlldndgkkih.......CAVK source prosite : PS00107 22) chain A residue 1200-1212 type prosite sequence FVHRDLAARNCML description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLAARNCML source prosite : PS00109 23) chain A residue 1110 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

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