eF-site ID 3edx-ABCDEF PDB Code 3edx Chain A, B, C, D, E, F click to enlarge Title Crystal structure of the W215A/E217A mutant of murine thrombin Classification HYDROLASE Compound Thrombin light chain Source (THRB_MOUSE) Sequence A:  FHTFFNEKTFGLGEADCGLRPLFEKKSLKDTTEKELLDSY ID B:  IVEGWDAEKGIAPWQVMLFRKSPQELLCGASLISDRWVLT AAHCILYPPWDKNFTENDLLVRIGKHSRTRYERNVEKISM LEKIYVHPRYNWRENLDRDIALLKLKKPVPFSDYIHPVCL PDKQTVTSLLRAGYKGRVTGWGNLRETWTTNINEIQPSVL QVVNLPIVERPVCKASTRIRITDNMFCAGFKVNDTKRGDA CEGDSGGPFVMKSPFNNRWYQMGIVSAGAGCDRKGKYGFY THVFRLKRWIQKVIDQFG C:  FHTFFNEKTFGLGEADCGLRPLFEKKSLKDTTEKELLDSY ID D:  IVEGWDAEKGIAPWQVMLFRKSPQELLCGASLISDRWVLT AAHCILYPPWDKNFTENDLLVRIGKHSRTRYERNVEKISM LEKIYVHPRYNWRENLDRDIALLKLKKPVPFSDYIHPVCL PDKQTVTSLLRAGYKGRVTGWGNLRETWTTNINEIQPSVL QVVNLPIVERPVCKASTRIRITDNMFCAGFKVNDTKRGDA CEGDSGGPFVMKSPFNNRWYQMGIVSAGAGCDRKGKYGFY THVFRLKRWIQKVIDQFG E:  FHTFFNEKTFGLGEADCGLRPLFEKKSLKDTTEKELLDSY ID F:  IVEGWDAEKGIAPWQVMLFRKSPQELLCGASLISDRWVLT AAHCILYPPWDKNFTENDLLVRIGKHSRTRYERNVEKISM LEKIYVHPRYNWRENLDRDIALLKLKKPVPFSDYIHPVCL PDKQTVTSLLRAGYKGRVTGWGNLRETWTTNINEIQPSVL QVVNLPIVERPVCKASTRIRITDNMFCAGFKVNDTKRGDA CEGDSGGPFVMKSPFNNRWYQMGIVSAGAGCDRKGKYGFY THVFRLKRWIQKVIDQFG Description Functional site 1) chain B residue 53-58 type prosite sequence LTAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC source prosite : PS00134 2) chain B residue 189-200 type prosite sequence DACEGDSGGPFV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV source prosite : PS00135 3) chain B residue 57 type ACT_SITE sequence H description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 4) chain B residue 102 type ACT_SITE sequence D description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 5) chain B residue 195 type ACT_SITE sequence S description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 6) chain D residue 57 type ACT_SITE sequence H description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 7) chain D residue 102 type ACT_SITE sequence D description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 8) chain D residue 195 type ACT_SITE sequence S description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 9) chain F residue 57 type ACT_SITE sequence H description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 10) chain F residue 102 type ACT_SITE sequence D description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 11) chain F residue 195 type ACT_SITE sequence S description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 12) chain B residue 60 type CARBOHYD sequence L description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17330941 source Swiss-Prot : SWS_FT_FI2 13) chain B residue 186 type CARBOHYD sequence V description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17330941 source Swiss-Prot : SWS_FT_FI2 14) chain D residue 60 type CARBOHYD sequence L description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17330941 source Swiss-Prot : SWS_FT_FI2 15) chain D residue 186 type CARBOHYD sequence V description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17330941 source Swiss-Prot : SWS_FT_FI2 16) chain F residue 60 type CARBOHYD sequence L description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17330941 source Swiss-Prot : SWS_FT_FI2 17) chain F residue 186 type CARBOHYD sequence V description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17330941 source Swiss-Prot : SWS_FT_FI2

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