eF-site ID 3ecr-AB PDB Code 3ecr Chain A, B click to enlarge Title Structure of human porphobilinogen deaminase Classification TRANSFERASE Compound Porphobilinogen deaminase Source Homo sapiens (Human) (HEM3_HUMAN) Sequence A:  MRVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAML FTKELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKR ENPHDAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQR KFPHLEFRSIRGNLNTRLRKLDEQQEFSAIILATAGLQRM GWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVG VLHDPETLLRCIAERAFLRHLECSVPVAVHTAMKDGQLYL TGGVWSLDGSDSIQETMQATIHVPAQHEDGPEDDPQLVGI TARNIPRGPQLAAQNLGISLANLLLSKGAKNILDVARQ B:  RVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMKI GEKSLFTKELEHALEKNEVDLVVHSLKDLPTVLPPGFTIG AICKRENPHDAVVFHPKFVGKTLETLPEKSVVGTSSLRRA AQLQRKFPHLEFRSIRGNLNTRLRKLDEQQEFSAIILATA GLQRMGWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDI LDLVGVLHDPETLLRCIAERAFLRHLECSVPVAVHTAMKD GQLYLTGGVWSLDGSDSIQETMQATIHPQLVGITARNIPR GPQLAAQNLGISLANLLLSKGAKNILDVAR Description Functional site 1) chain A residue 99 type sequence S description BINDING SITE FOR RESIDUE DPM A 365 source : AC1 2) chain A residue 101 type sequence K description BINDING SITE FOR RESIDUE DPM A 365 source : AC1 3) chain A residue 102 type sequence D description BINDING SITE FOR RESIDUE DPM A 365 source : AC1 4) chain A residue 148 type sequence T description BINDING SITE FOR RESIDUE DPM A 365 source : AC1 5) chain A residue 149 type sequence S description BINDING SITE FOR RESIDUE DPM A 365 source : AC1 6) chain A residue 150 type sequence S description BINDING SITE FOR RESIDUE DPM A 365 source : AC1 7) chain A residue 152 type sequence R description BINDING SITE FOR RESIDUE DPM A 365 source : AC1 8) chain A residue 153 type sequence R description BINDING SITE FOR RESIDUE DPM A 365 source : AC1 9) chain A residue 176 type sequence R description BINDING SITE FOR RESIDUE DPM A 365 source : AC1 10) chain A residue 191 type sequence L description BINDING SITE FOR RESIDUE DPM A 365 source : AC1 11) chain A residue 192 type sequence A description BINDING SITE FOR RESIDUE DPM A 365 source : AC1 12) chain A residue 220 type sequence Q description BINDING SITE FOR RESIDUE DPM A 365 source : AC1 13) chain A residue 221 type sequence G description BINDING SITE FOR RESIDUE DPM A 365 source : AC1 14) chain A residue 264 type sequence C description BINDING SITE FOR RESIDUE DPM A 365 source : AC1 15) chain B residue 74 type sequence I description BINDING SITE FOR RESIDUE DPM B 365 source : AC2 16) chain B residue 99 type sequence S description BINDING SITE FOR RESIDUE DPM B 365 source : AC2 17) chain B residue 101 type sequence K description BINDING SITE FOR RESIDUE DPM B 365 source : AC2 18) chain B residue 102 type sequence D description BINDING SITE FOR RESIDUE DPM B 365 source : AC2 19) chain B residue 149 type sequence S description BINDING SITE FOR RESIDUE DPM B 365 source : AC2 20) chain B residue 150 type sequence S description BINDING SITE FOR RESIDUE DPM B 365 source : AC2 21) chain B residue 152 type sequence R description BINDING SITE FOR RESIDUE DPM B 365 source : AC2 22) chain B residue 153 type sequence R description BINDING SITE FOR RESIDUE DPM B 365 source : AC2 23) chain B residue 176 type sequence R description BINDING SITE FOR RESIDUE DPM B 365 source : AC2 24) chain B residue 191 type sequence L description BINDING SITE FOR RESIDUE DPM B 365 source : AC2 25) chain B residue 192 type sequence A description BINDING SITE FOR RESIDUE DPM B 365 source : AC2 26) chain B residue 220 type sequence Q description BINDING SITE FOR RESIDUE DPM B 365 source : AC2 27) chain B residue 221 type sequence G description BINDING SITE FOR RESIDUE DPM B 365 source : AC2 28) chain B residue 264 type sequence C description BINDING SITE FOR RESIDUE DPM B 365 source : AC2 29) chain A residue 150 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 30) chain B residue 150 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 31) chain B residue 77 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P22907 source Swiss-Prot : SWS_FT_FI3 32) chain A residue 264 type MOD_RES sequence C description S-(dipyrrolylmethanemethyl)cysteine => ECO:0000269|PubMed:18936296 source Swiss-Prot : SWS_FT_FI4 33) chain B residue 264 type MOD_RES sequence C description S-(dipyrrolylmethanemethyl)cysteine => ECO:0000269|PubMed:18936296 source Swiss-Prot : SWS_FT_FI4 34) chain A residue 253-269 type prosite sequence ERAFLRHLECSVPVA description PORPHOBILINOGEN_DEAM Porphobilinogen deaminase cofactor-binding site. ERaFlrhLeGGCsVPVA source prosite : PS00533

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