|
eF-site ID
|
3e50-B |
PDB Code
|
3e50 |
Chain
|
B |
|
click to enlarge
|
|
Title
|
Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha |
Classification
|
Hydrolase/Hormone |
Compound
|
Insulin-degrading enzyme |
Source
|
Homo sapiens (Human) (TGFA_HUMAN) |
|
Sequence
|
B: |
PAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTD
KSSAALDVHIGSLSDPPNIAGLSHFCQHMLFLGTKKYPKE
NEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDR
FAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQL
EKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKF
HSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVP
LPEFPEHPQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKY
YKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKE
GARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEG
PQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYP
LEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSF
EGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLP
TKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDD
KFFLPKACLNFEFFSPFAYVDPLHCNMALYLELLKDSLNE
YAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKII
EKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYL
RLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIE
ALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRY
REVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENM
FLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGQGLR
FIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQ
ALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAY
LKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMSCPV
VGNLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPH
|
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Description
|
|
Functional site
|
|
1)
|
chain |
B |
residue |
108 |
type |
|
sequence |
H
|
description |
BINDING SITE FOR RESIDUE ZN D 51
|
source |
: AC2
|
|
2)
|
chain |
B |
residue |
112 |
type |
|
sequence |
H
|
description |
BINDING SITE FOR RESIDUE ZN D 51
|
source |
: AC2
|
|
3)
|
chain |
B |
residue |
189 |
type |
|
sequence |
E
|
description |
BINDING SITE FOR RESIDUE ZN D 51
|
source |
: AC2
|
|
4)
|
chain |
B |
residue |
111 |
type |
ACT_SITE |
sequence |
Q
|
description |
Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000305|PubMed:10684867, ECO:0000305|PubMed:17051221, ECO:0000305|PubMed:19321446, ECO:0000305|PubMed:23922390
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
5)
|
chain |
B |
residue |
108 |
type |
BINDING |
sequence |
H
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
6)
|
chain |
B |
residue |
112 |
type |
BINDING |
sequence |
H
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
7)
|
chain |
B |
residue |
189 |
type |
BINDING |
sequence |
E
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
8)
|
chain |
B |
residue |
336 |
type |
BINDING |
sequence |
H
|
description |
in the exosite
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
9)
|
chain |
B |
residue |
359 |
type |
BINDING |
sequence |
L
|
description |
BINDING => ECO:0000269|PubMed:18986166
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
10)
|
chain |
B |
residue |
429 |
type |
BINDING |
sequence |
R
|
description |
BINDING => ECO:0000250|UniProtKB:P35559
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
11)
|
chain |
B |
residue |
895 |
type |
BINDING |
sequence |
D
|
description |
BINDING => ECO:0000250|UniProtKB:P35559
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
12)
|
chain |
B |
residue |
192 |
type |
MOD_RES |
sequence |
K
|
description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
|
source |
Swiss-Prot : SWS_FT_FI6
|
|
13)
|
chain |
B |
residue |
697 |
type |
MOD_RES |
sequence |
K
|
description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
|
source |
Swiss-Prot : SWS_FT_FI6
|
|
|
|