eF-site ID 3e3r-AB PDB Code 3e3r Chain A, B click to enlarge Title Crystal structure and biochemical characterization of recombinant human calcyphosine delineates a novel EF-hand-containing protein family Classification CALCIUM BINDING PROTEIN Compound Calcyphosin Source Homo sapiens (Human) (CAYP1_HUMAN) Sequence A:  SSGLVPRMDAVDATMEKLRAARFFRQLDRDGSRSLDADEF RQGLAKLGLVLDQAEAEGVCRKWDRNGSGTLDLEEFLRAL RPPMSQAREAVIAAAFAKLDRSGDGVVTVDDLRGVYSGRA HPKVRSGEWTEDEVLRRFLDNFDSSEKDGQVTLAEFQDYY SGVSASMNTDEEFVAMMTSAWQL B:  VDATMEKLRAQCLSRGGIQGLARFFRQLDRDGSRSLDADE FRQGLAKLGLVLDQAEAEGVCRKWDRNGSGTLDLEEFLRA LRPPMSQAREAVIAAAFAKLDRSGDGVVTVDDLRGVYSGE WTEDEVLRRFLDNFDSSEKDGQVTLAEFQDYYSGVSASMN TDEEFVAMMTSAWQL Description Functional site 1) chain A residue 70 type sequence D description BINDING SITE FOR RESIDUE CA A 192 source : AC1 2) chain A residue 72 type sequence N description BINDING SITE FOR RESIDUE CA A 192 source : AC1 3) chain A residue 74 type sequence S description BINDING SITE FOR RESIDUE CA A 192 source : AC1 4) chain A residue 76 type sequence T description BINDING SITE FOR RESIDUE CA A 192 source : AC1 5) chain A residue 81 type sequence E description BINDING SITE FOR RESIDUE CA A 192 source : AC1 6) chain A residue 149 type sequence D description BINDING SITE FOR RESIDUE CA A 194 source : AC2 7) chain A residue 154 type sequence D description BINDING SITE FOR RESIDUE CA A 194 source : AC2 8) chain A residue 156 type sequence Q description BINDING SITE FOR RESIDUE CA A 194 source : AC2 9) chain A residue 161 type sequence E description BINDING SITE FOR RESIDUE CA A 194 source : AC2 10) chain A residue 90 type sequence M description BINDING SITE FOR RESIDUE CA A 195 source : AC3 11) chain A residue 95 type sequence E description BINDING SITE FOR RESIDUE CA A 195 source : AC3 12) chain A residue 34 type sequence D description BINDING SITE FOR RESIDUE CA A 197 source : AC4 13) chain A residue 36 type sequence D description BINDING SITE FOR RESIDUE CA A 197 source : AC4 14) chain A residue 38 type sequence S description BINDING SITE FOR RESIDUE CA A 197 source : AC4 15) chain A residue 40 type sequence S description BINDING SITE FOR RESIDUE CA A 197 source : AC4 16) chain A residue 42 type sequence D description BINDING SITE FOR RESIDUE CA A 197 source : AC4 17) chain A residue 45 type sequence E description BINDING SITE FOR RESIDUE CA A 197 source : AC4 18) chain A residue 106 type sequence D description BINDING SITE FOR RESIDUE CA A 196 source : AC5 19) chain A residue 108 type sequence S description BINDING SITE FOR RESIDUE CA A 196 source : AC5 20) chain A residue 110 type sequence D description BINDING SITE FOR RESIDUE CA A 196 source : AC5 21) chain A residue 112 type sequence V description BINDING SITE FOR RESIDUE CA A 196 source : AC5 22) chain A residue 117 type sequence D description BINDING SITE FOR RESIDUE CA A 196 source : AC5 23) chain B residue 70 type sequence D description BINDING SITE FOR RESIDUE CA B 192 source : AC6 24) chain B residue 72 type sequence N description BINDING SITE FOR RESIDUE CA B 192 source : AC6 25) chain B residue 74 type sequence S description BINDING SITE FOR RESIDUE CA B 192 source : AC6 26) chain B residue 76 type sequence T description BINDING SITE FOR RESIDUE CA B 192 source : AC6 27) chain B residue 81 type sequence E description BINDING SITE FOR RESIDUE CA B 192 source : AC6 28) chain B residue 177 type sequence E description BINDING SITE FOR RESIDUE CA B 192 source : AC6 29) chain B residue 149 type sequence D description BINDING SITE FOR RESIDUE CA B 193 source : AC7 30) chain B residue 154 type sequence D description BINDING SITE FOR RESIDUE CA B 193 source : AC7 31) chain B residue 156 type sequence Q description BINDING SITE FOR RESIDUE CA B 193 source : AC7 32) chain B residue 161 type sequence E description BINDING SITE FOR RESIDUE CA B 193 source : AC7 33) chain B residue 106 type sequence D description BINDING SITE FOR RESIDUE CA B 194 source : AC8 34) chain B residue 108 type sequence S description BINDING SITE FOR RESIDUE CA B 194 source : AC8 35) chain B residue 110 type sequence D description BINDING SITE FOR RESIDUE CA B 194 source : AC8 36) chain B residue 112 type sequence V description BINDING SITE FOR RESIDUE CA B 194 source : AC8 37) chain B residue 117 type sequence D description BINDING SITE FOR RESIDUE CA B 194 source : AC8 38) chain B residue 34 type sequence D description BINDING SITE FOR RESIDUE CA B 195 source : AC9 39) chain B residue 36 type sequence D description BINDING SITE FOR RESIDUE CA B 195 source : AC9 40) chain B residue 38 type sequence S description BINDING SITE FOR RESIDUE CA B 195 source : AC9 41) chain B residue 40 type sequence S description BINDING SITE FOR RESIDUE CA B 195 source : AC9 42) chain B residue 42 type sequence D description BINDING SITE FOR RESIDUE CA B 195 source : AC9 43) chain B residue 45 type sequence E description BINDING SITE FOR RESIDUE CA B 195 source : AC9 44) chain A residue 34-46 type prosite sequence DRDGSRSLDADEF description EF_HAND_1 EF-hand calcium-binding domain. DRDGSRSLDadEF source prosite : PS00018 45) chain A residue 70-82 type prosite sequence DRNGSGTLDLEEF description EF_HAND_1 EF-hand calcium-binding domain. DRDGSRSLDadEF source prosite : PS00018 46) chain A residue 106-118 type prosite sequence DRSGDGVVTVDDL description EF_HAND_1 EF-hand calcium-binding domain. DRDGSRSLDadEF source prosite : PS00018 47) chain A residue 120 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI1 48) chain A residue 167 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI1 49) chain B residue 120 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI1 50) chain B residue 122 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI1 51) chain B residue 156 type BINDING sequence Q description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI1 52) chain B residue 158 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI1 53) chain B residue 160 type BINDING sequence A description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI1 54) chain B residue 162 type BINDING sequence F description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI1 55) chain A residue 122 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI1 56) chain B residue 167 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI1 57) chain A residue 124 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI1 58) chain A residue 126 type BINDING sequence A description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI1 59) chain A residue 131 type BINDING sequence R description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI1 60) chain A residue 156 type BINDING sequence Q description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI1 61) chain A residue 158 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI1 62) chain A residue 160 type BINDING sequence A description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI1 63) chain A residue 162 type BINDING sequence F description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI1 64) chain A residue 126 type MOD_RES sequence A description Phosphoserine; by PKA => ECO:0000255 source Swiss-Prot : SWS_FT_FI2

Display surface Download Links