eF-site ID 3dzu-D PDB Code 3dzu Chain D click to enlarge Title Intact PPAR gamma - RXR alpha Nuclear Receptor Complex on DNA bound with BVT.13, 9-cis Retinoic Acid and NCOA2 Peptide Classification Transcription/DNA Compound Retinoic acid receptor RXR-alpha Source Homo sapiens (Human) (3DZU) Sequence D:  AIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDR CDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQ AEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFP LTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFEVA IRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLL KYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRK PFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRP GLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQK MTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY Description Functional site 1) chain D residue 111 type sequence C description BINDING SITE FOR RESIDUE ZN D 7121 source : AC1 2) chain D residue 114 type sequence C description BINDING SITE FOR RESIDUE ZN D 7121 source : AC1 3) chain D residue 128 type sequence C description BINDING SITE FOR RESIDUE ZN D 7121 source : AC1 4) chain D residue 131 type sequence C description BINDING SITE FOR RESIDUE ZN D 7121 source : AC1 5) chain D residue 148 type sequence C description BINDING SITE FOR RESIDUE ZN D 7122 source : AC2 6) chain D residue 150 type sequence L description BINDING SITE FOR RESIDUE ZN D 7122 source : AC2 7) chain D residue 152 type sequence C description BINDING SITE FOR RESIDUE ZN D 7122 source : AC2 8) chain D residue 162 type sequence C description BINDING SITE FOR RESIDUE ZN D 7122 source : AC2 9) chain D residue 165 type sequence C description BINDING SITE FOR RESIDUE ZN D 7122 source : AC2 10) chain D residue 280 type sequence R description BINDING SITE FOR RESIDUE PLB D 701 source : AC6 11) chain D residue 281 type sequence I description BINDING SITE FOR RESIDUE PLB D 701 source : AC6 12) chain D residue 284 type sequence G description BINDING SITE FOR RESIDUE PLB D 701 source : AC6 13) chain D residue 285 type sequence C description BINDING SITE FOR RESIDUE PLB D 701 source : AC6 14) chain D residue 288 type sequence R description BINDING SITE FOR RESIDUE PLB D 701 source : AC6 15) chain D residue 333 type sequence L description BINDING SITE FOR RESIDUE PLB D 701 source : AC6 16) chain D residue 340 type sequence L description BINDING SITE FOR RESIDUE PLB D 701 source : AC6 17) chain D residue 341 type sequence I description BINDING SITE FOR RESIDUE PLB D 701 source : AC6 18) chain D residue 342 type sequence S description BINDING SITE FOR RESIDUE PLB D 701 source : AC6 19) chain D residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI3 20) chain D residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI3 21) chain D residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI3 22) chain D residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI3 23) chain D residue 108-182 type DNA_BIND sequence AIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDR CDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRF description Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI1 24) chain D residue 111-131 type ZN_FING sequence CRVCGDKASGFHYGVHACEGC description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2 25) chain D residue 148-170 type ZN_FING sequence CDLNCRIHKKSRNKCQYCRFQKC description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2 26) chain D residue 111-137 type prosite sequence CRVCGDKASGFHYGVHACEGCKGFFRR description NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CaiCg.Drssgk.HYgvysCegCkgFFkR source prosite : PS00031 27) chain D residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI5

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