eF-site ID 3dzf-ABCDEF
PDB Code 3dzf
Chain A, B, C, D, E, F

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Title Crystal structure of human CD38 extracellular domain complexed with a covalent intermediate, ara-F-ribose-5'-phosphate
Classification HYDROLASE
Compound ADP-ribosyl cyclase 1
Source (CD38_HUMAN)
Sequence A:  RWRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQS
VWDAFKGAFISKHPCDITEEDYQPLMKLGTQTVPCNKILL
WSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFD
TSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVV
HVMLDGSRSKIFDKDSTFGSVEVHNLQPEKVQTLEAWVIH
GGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKF
LQCVKNPEDSSC
B:  RWRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQS
VWDAFKGAFISKHPCDITEEDYQPLMKLGTQTVPCNKILL
WSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFD
TSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVV
HVMLDGSRSKIFDKDSTFGSVEVHNLQPEKVQTLEAWVIH
GGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKF
LQCVKNPEDSSC
C:  RWRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQS
VWDAFKGAFISKHPCDITEEDYQPLMKLGTQTVPCNKILL
WSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFD
TSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVV
HVMLDGSRSKIFDKDSTFGSVEVHNLQPEKVQTLEAWVIH
GGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKF
LQCVKNPEDSSC
D:  RWRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQS
VWDAFKGAFISKHPCDITEEDYQPLMKLGTQTVPCNKILL
WSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFD
TSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVV
HVMLDGSRSKIFDKDSTFGSVEVHNLQPEKVQTLEAWVIH
GGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKF
LQCVKNPEDSSC
E:  RWRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQS
VWDAFKGAFISKHPCDITEEDYQPLMKLGTQTVPCNKILL
WSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFD
TSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVV
HVMLDGSRSKIFDKDSTFGSVEVHNLQPEKVQTLEAWVIH
GGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKF
LQCVKNPEDSSC
F:  RWRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQS
VWDAFKGAFISKHPCDITEEDYQPLMKLGTQTVPCNKILL
WSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFD
TSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVV
HVMLDGSRSKIFDKDSTFGSVEVHNLQPEKVQTLEAWVIH
GGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKF
LQCVKNPEDSSC
Description


Functional site
1) chain A
residue 164
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3
2) chain B
residue 164
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3
3) chain C
residue 164
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3
4) chain D
residue 164
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3
5) chain E
residue 164
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3
6) chain F
residue 164
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3
7) chain A
residue 219
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973
source Swiss-Prot : SWS_FT_FI4
8) chain B
residue 219
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973
source Swiss-Prot : SWS_FT_FI4
9) chain C
residue 219
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973
source Swiss-Prot : SWS_FT_FI4
10) chain D
residue 219
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973
source Swiss-Prot : SWS_FT_FI4
11) chain E
residue 219
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973
source Swiss-Prot : SWS_FT_FI4
12) chain F
residue 219
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973
source Swiss-Prot : SWS_FT_FI4
13) chain A
residue 119
type ACT_SITE
sequence C
description ACT_SITE => ECO:0000305|PubMed:7961800
source Swiss-Prot : SWS_FT_FI1
14) chain E
residue 201
type ACT_SITE
sequence C
description ACT_SITE => ECO:0000305|PubMed:7961800
source Swiss-Prot : SWS_FT_FI1
15) chain F
residue 119
type ACT_SITE
sequence C
description ACT_SITE => ECO:0000305|PubMed:7961800
source Swiss-Prot : SWS_FT_FI1
16) chain F
residue 201
type ACT_SITE
sequence C
description ACT_SITE => ECO:0000305|PubMed:7961800
source Swiss-Prot : SWS_FT_FI1
17) chain A
residue 201
type ACT_SITE
sequence C
description ACT_SITE => ECO:0000305|PubMed:7961800
source Swiss-Prot : SWS_FT_FI1
18) chain B
residue 119
type ACT_SITE
sequence C
description ACT_SITE => ECO:0000305|PubMed:7961800
source Swiss-Prot : SWS_FT_FI1
19) chain B
residue 201
type ACT_SITE
sequence C
description ACT_SITE => ECO:0000305|PubMed:7961800
source Swiss-Prot : SWS_FT_FI1
20) chain C
residue 119
type ACT_SITE
sequence C
description ACT_SITE => ECO:0000305|PubMed:7961800
source Swiss-Prot : SWS_FT_FI1
21) chain C
residue 201
type ACT_SITE
sequence C
description ACT_SITE => ECO:0000305|PubMed:7961800
source Swiss-Prot : SWS_FT_FI1
22) chain D
residue 119
type ACT_SITE
sequence C
description ACT_SITE => ECO:0000305|PubMed:7961800
source Swiss-Prot : SWS_FT_FI1
23) chain D
residue 201
type ACT_SITE
sequence C
description ACT_SITE => ECO:0000305|PubMed:7961800
source Swiss-Prot : SWS_FT_FI1
24) chain E
residue 119
type ACT_SITE
sequence C
description ACT_SITE => ECO:0000305|PubMed:7961800
source Swiss-Prot : SWS_FT_FI1
25) chain A
residue 100
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
source Swiss-Prot : SWS_FT_FI2
26) chain E
residue 209
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
source Swiss-Prot : SWS_FT_FI2
27) chain F
residue 100
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
source Swiss-Prot : SWS_FT_FI2
28) chain F
residue 209
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
source Swiss-Prot : SWS_FT_FI2
29) chain A
residue 209
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
source Swiss-Prot : SWS_FT_FI2
30) chain B
residue 100
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
source Swiss-Prot : SWS_FT_FI2
31) chain B
residue 209
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
source Swiss-Prot : SWS_FT_FI2
32) chain C
residue 100
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
source Swiss-Prot : SWS_FT_FI2
33) chain C
residue 209
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
source Swiss-Prot : SWS_FT_FI2
34) chain D
residue 100
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
source Swiss-Prot : SWS_FT_FI2
35) chain D
residue 209
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
source Swiss-Prot : SWS_FT_FI2
36) chain E
residue 100
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
source Swiss-Prot : SWS_FT_FI2

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