eF-site ID 3dxb-ABCDEFGH PDB Code 3dxb Chain A, B, C, D, E, F, G, H click to enlarge Title Structure of the UHM domain of Puf60 fused to thioredoxin Classification SPLICING, TRANSCRIPTION Compound thioredoxin N-terminally fused to Puf60(UHM) Source Homo sapiens (Human) (PUF60_HUMAN) Sequence A:  PMSDKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMI APILDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTL LLFKNGEVAATKVGALSKGQLKEFLDANLAGSAMESTVMV LRNMVDPKDIDDDLEGEVTEECGKFGAVNRVIIYQEKQGE EEDAEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAE VYDQERFDNSDLSA B:  DKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPI LDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLF KNGEVAATKVGALSKGQLKEFLDANLAGSAMESTVMVLRN MVDPKDIDDDLEGEVTEECGKFGAVNRVIIYQEKQGEEED AEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVYD QERFDNSDLSA C:  DKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPI LDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLF KNGEVAATKVGALSKGQLKEFLDANLAGSAMESTVMVLRN MVDPKDIDDDLEGEVTEECGKFGAVNRVIIYQEKQGEEED AEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVYD QERFDNSDLSA D:  HHPMSDKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCK MIAPILDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIP TLLLFKNGEVAATKVGALSKGQLKEFLDANLAGSAMESTV MVLRNMVDPKDIDDDLEGEVTEECGKFGAVNRVIIYQEKQ GEEEDAEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVV AEVYDQERFDNSDLSA E:  KIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPIL DEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFK NGEVAATKVGALSKGQLKEFLDANLAGSAMESTVMVLRNM VDPKDIDDDLEGEVTEECGKFGAVNRVIIYQEKQGEEEDA EIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVYDQ ERFDNSDLSA F:  DKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPI LDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLF KNGEVAATKVGALSKGQLKEFLDANLAGSAMESTVMVLRN MVDPKDIDDDLEGEVTEECGKFGAVNRVIIYQEKQGEEED AEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVYD QERFDNSDLSA G:  DKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPI LDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLF KNGEVAATKVGALSKGQLKEFLDANLAGSAMESTVMVLRN MVDPKDIDDDLEGEVTEECGKFGAVNRVIIYQEKQGEEED AEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVYD QERFDNSDLSA H:  DKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPI LDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLF KNGEVAATKVGALSKGQLKEFLDANLAGSAMESTVMVLRN MVDPKDIDDDLEGEVTEECGKFGAVNRVIIYQEKQGEEED AEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVYD QERFDNSDLSA Description Functional site 1) chain A residue 350 type sequence H description BINDING SITE FOR RESIDUE CL A 1 source : AC1 2) chain A residue 372 type sequence W description BINDING SITE FOR RESIDUE CL A 1 source : AC1 3) chain E residue 464 type sequence R description BINDING SITE FOR RESIDUE EDO E 557 source : AC2 4) chain E residue 544 type sequence Y description BINDING SITE FOR RESIDUE EDO E 557 source : AC2 5) chain E residue 545 type sequence D description BINDING SITE FOR RESIDUE EDO E 557 source : AC2 6) chain E residue 556 type sequence A description BINDING SITE FOR RESIDUE EDO E 557 source : AC2 7) chain A residue 368-386 type prosite sequence LVDFWAEWCGPCKMIAPIL description THIOREDOXIN_1 Thioredoxin family active site. LVdFWaeWCGPCKmIapiL source prosite : PS00194 8) chain A residue 376 type ACT_SITE sequence C description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 9) chain E residue 379 type ACT_SITE sequence C description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 10) chain F residue 376 type ACT_SITE sequence C description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 11) chain F residue 379 type ACT_SITE sequence C description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 12) chain G residue 376 type ACT_SITE sequence C description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 13) chain G residue 379 type ACT_SITE sequence C description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 14) chain H residue 376 type ACT_SITE sequence C description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 15) chain H residue 379 type ACT_SITE sequence C description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 379 type ACT_SITE sequence C description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 17) chain B residue 376 type ACT_SITE sequence C description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 18) chain B residue 379 type ACT_SITE sequence C description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 19) chain C residue 376 type ACT_SITE sequence C description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 20) chain C residue 379 type ACT_SITE sequence C description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 21) chain D residue 376 type ACT_SITE sequence C description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 22) chain D residue 379 type ACT_SITE sequence C description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 23) chain E residue 376 type ACT_SITE sequence C description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 370 type SITE sequence D description Deprotonates C-terminal active site Cys => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 25) chain B residue 370 type SITE sequence D description Deprotonates C-terminal active site Cys => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 26) chain C residue 370 type SITE sequence D description Deprotonates C-terminal active site Cys => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 27) chain D residue 370 type SITE sequence D description Deprotonates C-terminal active site Cys => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 28) chain E residue 370 type SITE sequence D description Deprotonates C-terminal active site Cys => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 29) chain F residue 370 type SITE sequence D description Deprotonates C-terminal active site Cys => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 30) chain G residue 370 type SITE sequence D description Deprotonates C-terminal active site Cys => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 31) chain H residue 370 type SITE sequence D description Deprotonates C-terminal active site Cys => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 32) chain A residue 377 type SITE sequence G description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 33) chain E residue 378 type SITE sequence P description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 34) chain F residue 377 type SITE sequence G description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 35) chain F residue 378 type SITE sequence P description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 36) chain G residue 377 type SITE sequence G description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 37) chain G residue 378 type SITE sequence P description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 38) chain H residue 377 type SITE sequence G description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 39) chain H residue 378 type SITE sequence P description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 40) chain A residue 378 type SITE sequence P description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 41) chain B residue 377 type SITE sequence G description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 42) chain B residue 378 type SITE sequence P description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 43) chain C residue 377 type SITE sequence G description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 44) chain C residue 378 type SITE sequence P description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 45) chain D residue 377 type SITE sequence G description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 46) chain D residue 378 type SITE sequence P description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 47) chain E residue 377 type SITE sequence G description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 48) chain A residue 413 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 49) chain B residue 413 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 50) chain C residue 413 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 51) chain D residue 413 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 52) chain E residue 413 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 53) chain F residue 413 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 54) chain G residue 413 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 55) chain H residue 413 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250 source Swiss-Prot : SWS_FT_FI4

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