eF-site ID 3dxb-A PDB Code 3dxb Chain A click to enlarge Title Structure of the UHM domain of Puf60 fused to thioredoxin Classification SPLICING, TRANSCRIPTION Compound thioredoxin N-terminally fused to Puf60(UHM) Source Homo sapiens (Human) (PUF60_HUMAN) Sequence A:  PMSDKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMI APILDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTL LLFKNGEVAATKVGALSKGQLKEFLDANLAGSAMESTVMV LRNMVDPKDIDDDLEGEVTEECGKFGAVNRVIIYQEKQGE EEDAEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAE VYDQERFDNSDLSA Description Functional site 1) chain A residue 350 type sequence H description BINDING SITE FOR RESIDUE CL A 1 source : AC1 2) chain A residue 372 type sequence W description BINDING SITE FOR RESIDUE CL A 1 source : AC1 3) chain A residue 370 type SITE sequence D description Deprotonates C-terminal active site Cys => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 4) chain A residue 376 type ACT_SITE sequence C description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 5) chain A residue 379 type ACT_SITE sequence C description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 6) chain A residue 377 type SITE sequence G description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 7) chain A residue 378 type SITE sequence P description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 8) chain A residue 413 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 9) chain A residue 368-386 type prosite sequence LVDFWAEWCGPCKMIAPIL description THIOREDOXIN_1 Thioredoxin family active site. LVdFWaeWCGPCKmIapiL source prosite : PS00194

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