eF-site ID 3dx3-A
PDB Code 3dx3
Chain A

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Title Golgi alpha-Mannosidase II in complex with Mannostatin analog (1R,2R,3S,4R,5R)-5-aminocyclopentane-1,2,3,4-tetraol
Classification HYDROLASE
Compound Alpha-mannosidase 2
Source (MAN2_DROME)
Sequence A:  CQDVVQDVPNVDVQMLELYDRMSFKDIDGGVWKQGWNIKY
DPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQHDTKHI
LSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMK
SIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLK
QFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTH
YSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYD
IPHTCGPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQN
VAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEW
DVQRVNYERLFEHINSQAHFNVQAQFGTLQEYFDAVHQAE
RAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDR
VLMHYVRAAEMLSAWHSWDGMARIEERLEQARRELSLFQH
HDGITGTAKTHVVVDYEQRMQEALKACQMVMQQSVYRLLT
KPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDIL
PSKHVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPVEA
QVSPVWSWHHDTLTKTIHPQGSTTKYRIIFKARVPPMGLA
TYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDVKF
GDPREISLRVGNGPTLAFSEQGLLKSIQLTQDSPHVPVHF
KFLKYGVRSHGDRSGAYLFLPNGPASPVELGQPVVLVTKG
KLESSVSVGLPSVVHQTIMRGGAPEIRNLVDIGSLDNTEI
VMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYP
IPSGMFIEDANTRLTLLTGQPLGGSSLASGELEIMQDRRL
ASDDERGLGQGVLDNKPVLHIYRLVLEKVNNCVRPSKLHP
AGYLTSAAHKASQSLLDPLDKFIFAENEWIGAQGQFGGDH
PSAREDLDVSVMRRLTKSSAKTQRVGYVLHRTNLMQCGTP
EEHTQKLDVCHLLPNVARCERTTLTFLQNLEHLDGMVAPE
VCPMETAAYVSSHSS
Description


Functional site

1) chain A
residue 204
type ACT_SITE
sequence D
description Nucleophile => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

2) chain A
residue 90
type BINDING
sequence H
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

3) chain A
residue 92
type BINDING
sequence D
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

4) chain A
residue 204
type BINDING
sequence D
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

5) chain A
residue 471
type BINDING
sequence H
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

6) chain A
residue 90
type catalytic
sequence H
description 793
source MCSA : MCSA1

7) chain A
residue 92
type catalytic
sequence D
description 793
source MCSA : MCSA1

8) chain A
residue 204
type catalytic
sequence D
description 793
source MCSA : MCSA1

9) chain A
residue 341
type catalytic
sequence D
description 793
source MCSA : MCSA1

10) chain A
residue 471
type catalytic
sequence H
description 793
source MCSA : MCSA1


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