eF-site ID 3dva-ABCDEFGHIJ PDB Code 3dva Chain A, B, C, D, E, F, G, H, I, J click to enlarge Title Snapshots of catalysis in the E1 subunit of the pyruvate dehydrogenase multi-enzyme complex Classification OXIDOREDUCTASE/TRANSFERASE Compound Pyruvate dehydrogenase E1 component subunit alpha Source Geobacillus stearothermophilus (Bacillus stearothermophilus) (ODP2_BACST) Sequence A:  TFQFPFAEQLEKVAEQFPTFQILNEEGEVVNEEAMPELSD EQLKELMRRMVYTRILDQRSISLNRQGRLGFYAPTAGQEA SQIASHFALEKEDFILPGYRDVPQIIWHGLPLYQAFLFSR GHFHGNQIPEGVNVLPPQIIIGAQYIQAAGVALGLKMRGK KAVAITYTGDGGTSQGDFYEGINFAGAFKAPAIFVVQNNR FAASTPVEKQTVAKTLAQKAVAAGIPGIQVDGMDPLAVYA AVKAARERAINGEGPTLIETLCFRYGPHTMSGDDPTRYRS KELENEWAKKDPLVRFRKFLEAKGLWSEEEENNVIEQAKE EIKEAIKKADETPKQKVTDLISIMFEELPFNLKEQYEIYK EKESK B:  AQMTMVQAITDALRIELKNDPNVLIFGEDVGVNGGVFRAT EGLQAEFGEDRVFDTPLAESGIGGLAIGLALQGFRPVPEI QFFGFVYEVMDSICGQMARIRYRTGGRYHMPITIRSPFGG GVHTPELHSDSLEGLVAQQPGLKVVIPSTPYDAKGLLISA IRDNDPVIFLEHLKLYRSFRQEVPEGEYTIPIGKADIKRE GKDITIIAYGAMVHESLKAAAELEKEGISAEVVDLRTVQP LDIETIIGSVEKTGRAIVVQEAQRQAGIAANVVAEINERA ILSLEAPVLRVAAPDTVYPFAQAESVWLPNFKDVIETAKK VMNF C:  TFQFPFAEQLEKVAEQFPTFQILNEEGEVVNEEAMPELSD EQLKELMRRMVYTRILDQRSISLNRQGRLGFYAPTAGQEA SQIASHFALEKEDFILPGYRDVPQIIWHGLPLYQAFLFSR GHFHGNQIPEGVNVLPPQIIIGAQYIQAAGVALGLKMRGK KAVAITYTGDGGTSQGDFYEGINFAGAFKAPAIFVVQNNR FAASTPVEKQTVAKTLAQKAVAAGIPGIQVDGMDPLAVYA AVKAARERAINGEGPTLIETLCFRYGPHTMSGDDPTRYRS KELENEWAKKDPLVRFRKFLEAKGLWSEEEENNVIEQAKE EIKEAIKKADETPKQKVTDLISIMFEELPFNLKEQYEIYK EKESK D:  AQMTMVQAITDALRIELKNDPNVLIFGEDVGVNGGVFRAT EGLQAEFGEDRVFDTPLAESGIGGLAIGLALQGFRPVPEI QFFGFVYEVMDSICGQMARIRYRTGGRYHMPITIRSPFGG GVHTPELHSDSLEGLVAQQPGLKVVIPSTPYDAKGLLISA IRDNDPVIFLEHLKLYRSFRQEVPEGEYTIPIGKADIKRE GKDITIIAYGAMVHESLKAAAELEKEGISAEVVDLRTVQP LDIETIIGSVEKTGRAIVVQEAQRQAGIAANVVAEINERA ILSLEAPVLRVAAPDTVYPFAQAESVWLPNFKDVIETAKK VMNF E:  TFQFPFAEQLEKVAEQFPTFQILNEEGEVVNEEAMPELSD EQLKELMRRMVYTRILDQRSISLNRQGRLGFYAPTAGQEA SQIASHFALEKEDFILPGYRDVPQIIWHGLPLYQAFLFSR GHFHGNQIPEGVNVLPPQIIIGAQYIQAAGVALGLKMRGK KAVAITYTGDGGTSQGDFYEGINFAGAFKAPAIFVVQNNR FAASTPVEKQTVAKTLAQKAVAAGIPGIQVDGMDPLAVYA AVKAARERAINGEGPTLIETLCFRYGPHTMSGDNEWAKKD PLVRFRKFLEAKGLWSEEEENNVIEQAKEEIKEAIKKADE TPKQKVTDLISIMFEELPFNLKEQYEIYKEKESK F:  AQMTMVQAITDALRIELKNDPNVLIFGEDVGVNGGVFRAT EGLQAEFGEDRVFDTPLAESGIGGLAIGLALQGFRPVPEI QFFGFVYEVMDSICGQMARIRYRTGGRYHMPITIRSPFGG GVHTPELHSDSLEGLVAQQPGLKVVIPSTPYDAKGLLISA IRDNDPVIFLEHLKLYRSFRQEVPEGEYTIPIGKADIKRE GKDITIIAYGAMVHESLKAAAELEKEGISAEVVDLRTVQP LDIETIIGSVEKTGRAIVVQEAQRQAGIAANVVAEINERA ILSLEAPVLRVAAPDTVYPFAQAESVWLPNFKDVIETAKK VMNF G:  TFQFPFAEQLEKVAEQFPTFQILNEEGEVVNEEAMPELSD EQLKELMRRMVYTRILDQRSISLNRQGRLGFYAPTAGQEA SQIASHFALEKEDFILPGYRDVPQIIWHGLPLYQAFLFSR GHFHGNQIPEGVNVLPPQIIIGAQYIQAAGVALGLKMRGK KAVAITYTGDGGTSQGDFYEGINFAGAFKAPAIFVVQNNR FAASTPVEKQTVAKTLAQKAVAAGIPGIQVDGMDPLAVYA AVKAARERAINGEGPTLIETLCFRYGPHTMSGDDPTRYRS KELENEWAKKDPLVRFRKFLEAKGLWSEEEENNVIEQAKE EIKEAIKKADETPKQKVTDLISIMFEELPFNLKEQYEIYK EKESK H:  AQMTMVQAITDALRIELKNDPNVLIFGEDVGVNGGVFRAT EGLQAEFGEDRVFDTPLAESGIGGLAIGLALQGFRPVPEI QFFGFVYEVMDSICGQMARIRYRTGGRYHMPITIRSPFGG GVHTPELHSDSLEGLVAQQPGLKVVIPSTPYDAKGLLISA IRDNDPVIFLEHLKLYRSFRQEVPEGEYTIPIGKADIKRE GKDITIIAYGAMVHESLKAAAELEKEGISAEVVDLRTVQP LDIETIIGSVEKTGRAIVVQEAQRQAGIAANVVAEINERA ILSLEAPVLRVAAPDTVYPFAQAESVWLPNFKDVIETAKK VMNF I:  RVIAMPSVRKYAREKGVDIRLVQGTGKNGRVLKEDIDAFL AG J:  RVIAMPSVRKYAREKGVDIRLVQGTGKNGRVLKEDIDAFL Description Functional site 1) chain A residue 173 type sequence D description BINDING SITE FOR RESIDUE MG A1368 source : AC1 2) chain A residue 202 type sequence N description BINDING SITE FOR RESIDUE MG A1368 source : AC1 3) chain A residue 204 type sequence F description BINDING SITE FOR RESIDUE MG A1368 source : AC1 4) chain B residue 112 type sequence I description BINDING SITE FOR RESIDUE K B1325 source : AC2 5) chain B residue 113 type sequence T description BINDING SITE FOR RESIDUE K B1325 source : AC2 6) chain B residue 160 type sequence A description BINDING SITE FOR RESIDUE K B1325 source : AC2 7) chain B residue 163 type sequence D description BINDING SITE FOR RESIDUE K B1325 source : AC2 8) chain B residue 165 type sequence D description BINDING SITE FOR RESIDUE K B1325 source : AC2 9) chain C residue 173 type sequence D description BINDING SITE FOR RESIDUE MG C1368 source : AC4 10) chain C residue 202 type sequence N description BINDING SITE FOR RESIDUE MG C1368 source : AC4 11) chain C residue 204 type sequence F description BINDING SITE FOR RESIDUE MG C1368 source : AC4 12) chain D residue 112 type sequence I description BINDING SITE FOR RESIDUE K D1325 source : AC5 13) chain D residue 113 type sequence T description BINDING SITE FOR RESIDUE K D1325 source : AC5 14) chain D residue 160 type sequence A description BINDING SITE FOR RESIDUE K D1325 source : AC5 15) chain D residue 163 type sequence D description BINDING SITE FOR RESIDUE K D1325 source : AC5 16) chain D residue 165 type sequence D description BINDING SITE FOR RESIDUE K D1325 source : AC5 17) chain G residue 173 type sequence D description BINDING SITE FOR RESIDUE MG G 369 source : AC6 18) chain G residue 202 type sequence N description BINDING SITE FOR RESIDUE MG G 369 source : AC6 19) chain G residue 204 type sequence F description BINDING SITE FOR RESIDUE MG G 369 source : AC6 20) chain E residue 172 type sequence G description BINDING SITE FOR RESIDUE MG E 369 source : AC7 21) chain E residue 173 type sequence D description BINDING SITE FOR RESIDUE MG E 369 source : AC7 22) chain E residue 200 type sequence Q description BINDING SITE FOR RESIDUE MG E 369 source : AC7 23) chain E residue 202 type sequence N description BINDING SITE FOR RESIDUE MG E 369 source : AC7 24) chain E residue 204 type sequence F description BINDING SITE FOR RESIDUE MG E 369 source : AC7 25) chain A residue 102 type sequence Y description BINDING SITE FOR RESIDUE TPW A1370 source : AC9 26) chain A residue 103 type sequence R description BINDING SITE FOR RESIDUE TPW A1370 source : AC9 27) chain A residue 142 type sequence I description BINDING SITE FOR RESIDUE TPW A1370 source : AC9 28) chain A residue 144 type sequence I description BINDING SITE FOR RESIDUE TPW A1370 source : AC9 29) chain A residue 172 type sequence G description BINDING SITE FOR RESIDUE TPW A1370 source : AC9 30) chain A residue 173 type sequence D description BINDING SITE FOR RESIDUE TPW A1370 source : AC9 31) chain A residue 174 type sequence G description BINDING SITE FOR RESIDUE TPW A1370 source : AC9 32) chain A residue 175 type sequence G description BINDING SITE FOR RESIDUE TPW A1370 source : AC9 33) chain A residue 178 type sequence Q description BINDING SITE FOR RESIDUE TPW A1370 source : AC9 34) chain A residue 202 type sequence N description BINDING SITE FOR RESIDUE TPW A1370 source : AC9 35) chain A residue 204 type sequence F description BINDING SITE FOR RESIDUE TPW A1370 source : AC9 36) chain A residue 205 type sequence A description BINDING SITE FOR RESIDUE TPW A1370 source : AC9 37) chain A residue 267 type sequence R description BINDING SITE FOR RESIDUE TPW A1370 source : AC9 38) chain A residue 271 type sequence H description BINDING SITE FOR RESIDUE TPW A1370 source : AC9 39) chain D residue 28 type sequence E description BINDING SITE FOR RESIDUE TPW A1370 source : AC9 40) chain D residue 57 type sequence L description BINDING SITE FOR RESIDUE TPW A1370 source : AC9 41) chain D residue 59 type sequence E description BINDING SITE FOR RESIDUE TPW A1370 source : AC9 42) chain D residue 81 type sequence Q description BINDING SITE FOR RESIDUE TPW A1370 source : AC9 43) chain D residue 85 type sequence F description BINDING SITE FOR RESIDUE TPW A1370 source : AC9 44) chain B residue 28 type sequence E description BINDING SITE FOR RESIDUE TPW C1370 source : BC1 45) chain B residue 57 type sequence L description BINDING SITE FOR RESIDUE TPW C1370 source : BC1 46) chain B residue 59 type sequence E description BINDING SITE FOR RESIDUE TPW C1370 source : BC1 47) chain B residue 81 type sequence Q description BINDING SITE FOR RESIDUE TPW C1370 source : BC1 48) chain B residue 85 type sequence F description BINDING SITE FOR RESIDUE TPW C1370 source : BC1 49) chain C residue 102 type sequence Y description BINDING SITE FOR RESIDUE TPW C1370 source : BC1 50) chain C residue 103 type sequence R description BINDING SITE FOR RESIDUE TPW C1370 source : BC1 51) chain C residue 142 type sequence I description BINDING SITE FOR RESIDUE TPW C1370 source : BC1 52) chain C residue 144 type sequence I description BINDING SITE FOR RESIDUE TPW C1370 source : BC1 53) chain C residue 172 type sequence G description BINDING SITE FOR RESIDUE TPW C1370 source : BC1 54) chain C residue 173 type sequence D description BINDING SITE FOR RESIDUE TPW C1370 source : BC1 55) chain C residue 174 type sequence G description BINDING SITE FOR RESIDUE TPW C1370 source : BC1 56) chain C residue 175 type sequence G description BINDING SITE FOR RESIDUE TPW C1370 source : BC1 57) chain C residue 178 type sequence Q description BINDING SITE FOR RESIDUE TPW C1370 source : BC1 58) chain C residue 202 type sequence N description BINDING SITE FOR RESIDUE TPW C1370 source : BC1 59) chain C residue 204 type sequence F description BINDING SITE FOR RESIDUE TPW C1370 source : BC1 60) chain C residue 205 type sequence A description BINDING SITE FOR RESIDUE TPW C1370 source : BC1 61) chain C residue 206 type sequence A description BINDING SITE FOR RESIDUE TPW C1370 source : BC1 62) chain C residue 271 type sequence H description BINDING SITE FOR RESIDUE TPW C1370 source : BC1 63) chain E residue 102 type sequence Y description BINDING SITE FOR RESIDUE TPW E1370 source : BC2 64) chain E residue 103 type sequence R description BINDING SITE FOR RESIDUE TPW E1370 source : BC2 65) chain E residue 142 type sequence I description BINDING SITE FOR RESIDUE TPW E1370 source : BC2 66) chain E residue 144 type sequence I description BINDING SITE FOR RESIDUE TPW E1370 source : BC2 67) chain E residue 172 type sequence G description BINDING SITE FOR RESIDUE TPW E1370 source : BC2 68) chain E residue 173 type sequence D description BINDING SITE FOR RESIDUE TPW E1370 source : BC2 69) chain E residue 174 type sequence G description BINDING SITE FOR RESIDUE TPW E1370 source : BC2 70) chain E residue 175 type sequence G description BINDING SITE FOR RESIDUE TPW E1370 source : BC2 71) chain E residue 178 type sequence Q description BINDING SITE FOR RESIDUE TPW E1370 source : BC2 72) chain E residue 202 type sequence N description BINDING SITE FOR RESIDUE TPW E1370 source : BC2 73) chain E residue 204 type sequence F description BINDING SITE FOR RESIDUE TPW E1370 source : BC2 74) chain E residue 205 type sequence A description BINDING SITE FOR RESIDUE TPW E1370 source : BC2 75) chain E residue 206 type sequence A description BINDING SITE FOR RESIDUE TPW E1370 source : BC2 76) chain E residue 271 type sequence H description BINDING SITE FOR RESIDUE TPW E1370 source : BC2 77) chain H residue 28 type sequence E description BINDING SITE FOR RESIDUE TPW E1370 source : BC2 78) chain H residue 57 type sequence L description BINDING SITE FOR RESIDUE TPW E1370 source : BC2 79) chain H residue 59 type sequence E description BINDING SITE FOR RESIDUE TPW E1370 source : BC2 80) chain H residue 81 type sequence Q description BINDING SITE FOR RESIDUE TPW E1370 source : BC2 81) chain H residue 85 type sequence F description BINDING SITE FOR RESIDUE TPW E1370 source : BC2 82) chain F residue 28 type sequence E description BINDING SITE FOR RESIDUE TPW G1370 source : BC3 83) chain F residue 57 type sequence L description BINDING SITE FOR RESIDUE TPW G1370 source : BC3 84) chain F residue 59 type sequence E description BINDING SITE FOR RESIDUE TPW G1370 source : BC3 85) chain F residue 81 type sequence Q description BINDING SITE FOR RESIDUE TPW G1370 source : BC3 86) chain F residue 85 type sequence F description BINDING SITE FOR RESIDUE TPW G1370 source : BC3 87) chain G residue 102 type sequence Y description BINDING SITE FOR RESIDUE TPW G1370 source : BC3 88) chain G residue 103 type sequence R description BINDING SITE FOR RESIDUE TPW G1370 source : BC3 89) chain G residue 142 type sequence I description BINDING SITE FOR RESIDUE TPW G1370 source : BC3 90) chain G residue 144 type sequence I description BINDING SITE FOR RESIDUE TPW G1370 source : BC3 91) chain G residue 172 type sequence G description BINDING SITE FOR RESIDUE TPW G1370 source : BC3 92) chain G residue 173 type sequence D description BINDING SITE FOR RESIDUE TPW G1370 source : BC3 93) chain G residue 174 type sequence G description BINDING SITE FOR RESIDUE TPW G1370 source : BC3 94) chain G residue 175 type sequence G description BINDING SITE FOR RESIDUE TPW G1370 source : BC3 95) chain G residue 178 type sequence Q description BINDING SITE FOR RESIDUE TPW G1370 source : BC3 96) chain G residue 202 type sequence N description BINDING SITE FOR RESIDUE TPW G1370 source : BC3 97) chain G residue 204 type sequence F description BINDING SITE FOR RESIDUE TPW G1370 source : BC3 98) chain G residue 205 type sequence A description BINDING SITE FOR RESIDUE TPW G1370 source : BC3 99) chain G residue 206 type sequence A description BINDING SITE FOR RESIDUE TPW G1370 source : BC3 100) chain G residue 271 type sequence H description BINDING SITE FOR RESIDUE TPW G1370 source : BC3 101) chain B residue 59 type catalytic sequence E description 106 source MCSA : MCSA1 102) chain B residue 128 type catalytic sequence H description 106 source MCSA : MCSA1 103) chain A residue 281 type catalytic sequence Y description 106 source MCSA : MCSA1 104) chain D residue 59 type catalytic sequence E description 106 source MCSA : MCSA2 105) chain D residue 128 type catalytic sequence H description 106 source MCSA : MCSA2 106) chain C residue 281 type catalytic sequence Y description 106 source MCSA : MCSA2 107) chain F residue 59 type catalytic sequence E description 106 source MCSA : MCSA3 108) chain F residue 128 type catalytic sequence H description 106 source MCSA : MCSA3 109) chain H residue 59 type catalytic sequence E description 106 source MCSA : MCSA4 110) chain H residue 128 type catalytic sequence H description 106 source MCSA : MCSA4 111) chain G residue 281 type catalytic sequence Y description 106 source MCSA : MCSA4 112) chain F residue 59 type ACT_SITE sequence E description ACT_SITE => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 113) chain H residue 59 type ACT_SITE sequence E description ACT_SITE => ECO:0000255 source Swiss-Prot : SWS_FT_FI1

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