eF-site ID 3dnm-ABCD PDB Code 3dnm Chain A, B, C, D click to enlarge Title Crystal Structure Hormone-Sensitive Lipase from a Metagenome Library Classification HYDROLASE Compound Esterase/lipase Source uncultured bacterium (Q0GMU1_9BACT) Sequence A:  DTKMDPRDFLQLLKINAEKAEKNLPLDQKRAGMEALCERF PRAEGVELTLTDLGGVPCIRQATDGAGAAHILYFHGGGYI SGSPSTHLVLTTQLAKQSSATLWSLDYRLAPENPFPAAVD DCVAAYRALLKTAGSADRIIIAGDSAGGGLTTASMLKAKE DGLPMPAGLVMLSPFVDLTLSRWSNSNLADRDFLAEPDTL GEMSELYVGGEDRKNPLISPVYADLSGLPEMLIHVGSEEA LLSDSTTLAERAGAAGVSVELKIWPDMPHVFQMYGKFVNA ADISIKEICHWISARIS B:  DTKMDPRDFLQLLKINAEKAEKNLPLDQKRAGMEALCERF PRAEGVELTLTDLGGVPCIRQATDGAGAAHILYFHGGGYI SGSPSTHLVLTTQLAKQSSATLWSLDYRLAPENPFPAAVD DCVAAYRALLKTAGSADRIIIAGDSAGGGLTTASMLKAKE DGLPMPAGLVMLSPFVDLTLSRWSNSNLADRDFLAEPDTL GEMSELYVGGEDRKNPLISPVYADLSGLPEMLIHVGSEEA LLSDSTTLAERAGAAGVSVELKIWPDMPHVFQMYGKFVNA ADISIKEICHWISARI C:  TKMDPRDFLQLLKINAEKAPLDQKRAGMEALCERFPRAEG VELTLTDLGGVPCIRQATDGAGAAHILYFHGGGYISGSPS THLVLTTQLAKQSSATLWSLDYRLAPENPFPAAVDDCVAA YRALLKTAGSADRIIIAGDSAGGGLTTASMLKAKEDGLPM PAGLVMLSPFVDLTLSRWSNSNLADRDFLAEPDTLGEMSE LYVGGEDRKNPLISPVYADLSGLPEMLIHVGSEEALLSDS TTLAERAGAAGVSVELKIWPDMPHVFQMYGKFVNAADISI KEICHWISARI D:  KMDPRDFLQLLKINAEKALPLDQKRAGMEALCERFPRAEG VELTLTDLGGVPCIRQATDGAGAAHILYFHGGGYISGSPS THLVLTTQLAKQSSATLWSLDYRLAPENPFPAAVDDCVAA YRALLKTAGSADRIIIAGDSAGGGLTTASMLKAKEDGLPM PAGLVMLSPFVDLTLSRWSNSNLADRDFLAEPDTLGEMSE LYVGGEDRKNPLISPVYADLSGLPEMLIHVGSEEALLSDS TTLAERAGAAGVSVELKIWPDMPHVFQMYGKFVNAADISI KEICHWISARI Description Functional site 1) chain A residue 90 type sequence G description BINDING SITE FOR RESIDUE BME A 325 source : AC1 2) chain A residue 157 type sequence S description BINDING SITE FOR RESIDUE BME A 325 source : AC1 3) chain A residue 206 type sequence L description BINDING SITE FOR RESIDUE BME A 325 source : AC1 4) chain A residue 281 type sequence H description BINDING SITE FOR RESIDUE BME A 325 source : AC1 5) chain A residue 55 type sequence A description BINDING SITE FOR RESIDUE SO4 A 323 source : AC2 6) chain A residue 56 type sequence E description BINDING SITE FOR RESIDUE SO4 A 323 source : AC2 7) chain A residue 105 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 323 source : AC2 8) chain A residue 108 type sequence K description BINDING SITE FOR RESIDUE SO4 A 323 source : AC2 9) chain A residue 194 type sequence R description BINDING SITE FOR RESIDUE SO4 A 324 source : AC3 10) chain A residue 234 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 324 source : AC3 11) chain A residue 263 type sequence R description BINDING SITE FOR RESIDUE SO4 A 324 source : AC3 12) chain B residue 195 type sequence W description BINDING SITE FOR RESIDUE SO4 A 324 source : AC3 13) chain B residue 157 type sequence S description BINDING SITE FOR RESIDUE BME B 330 source : AC4 14) chain B residue 206 type sequence L description BINDING SITE FOR RESIDUE BME B 330 source : AC4 15) chain B residue 281 type sequence H description BINDING SITE FOR RESIDUE BME B 330 source : AC4 16) chain B residue 55 type sequence A description BINDING SITE FOR RESIDUE SO4 B 323 source : AC5 17) chain B residue 56 type sequence E description BINDING SITE FOR RESIDUE SO4 B 323 source : AC5 18) chain B residue 105 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 323 source : AC5 19) chain B residue 108 type sequence K description BINDING SITE FOR RESIDUE SO4 B 323 source : AC5 20) chain A residue 258 type sequence T description BINDING SITE FOR RESIDUE SO4 B 324 source : AC6 21) chain A residue 259 type sequence T description BINDING SITE FOR RESIDUE SO4 B 324 source : AC6 22) chain A residue 262 type sequence E description BINDING SITE FOR RESIDUE SO4 B 324 source : AC6 23) chain B residue 258 type sequence T description BINDING SITE FOR RESIDUE SO4 B 324 source : AC6 24) chain B residue 259 type sequence T description BINDING SITE FOR RESIDUE SO4 B 324 source : AC6 25) chain B residue 262 type sequence E description BINDING SITE FOR RESIDUE SO4 B 324 source : AC6 26) chain B residue 194 type sequence R description BINDING SITE FOR RESIDUE SO4 B 325 source : AC7 27) chain B residue 226 type sequence K description BINDING SITE FOR RESIDUE SO4 B 325 source : AC7 28) chain B residue 234 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 325 source : AC7 29) chain B residue 263 type sequence R description BINDING SITE FOR RESIDUE SO4 B 325 source : AC7 30) chain B residue 19 type sequence R description BINDING SITE FOR RESIDUE SO4 B 326 source : AC8 31) chain B residue 22 type sequence L description BINDING SITE FOR RESIDUE SO4 B 326 source : AC8 32) chain B residue 23 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 326 source : AC8 33) chain B residue 39 type sequence D description BINDING SITE FOR RESIDUE SO4 B 327 source : AC9 34) chain B residue 40 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 327 source : AC9 35) chain C residue 118 type sequence D description BINDING SITE FOR RESIDUE SO4 B 327 source : AC9 36) chain C residue 121 type sequence L description BINDING SITE FOR RESIDUE SO4 B 327 source : AC9 37) chain B residue 118 type sequence D description BINDING SITE FOR RESIDUE SO4 B 328 source : BC1 38) chain B residue 119 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 328 source : BC1 39) chain B residue 120 type sequence R description BINDING SITE FOR RESIDUE SO4 B 328 source : BC1 40) chain B residue 64 type sequence D description BINDING SITE FOR RESIDUE SO4 B 329 source : BC2 41) chain B residue 144 type sequence T description BINDING SITE FOR RESIDUE SO4 B 329 source : BC2 42) chain C residue 90 type sequence G description BINDING SITE FOR RESIDUE BME C 325 source : BC3 43) chain C residue 157 type sequence S description BINDING SITE FOR RESIDUE BME C 325 source : BC3 44) chain C residue 207 type sequence A description BINDING SITE FOR RESIDUE BME C 325 source : BC3 45) chain C residue 215 type sequence M description BINDING SITE FOR RESIDUE BME C 325 source : BC3 46) chain C residue 281 type sequence H description BINDING SITE FOR RESIDUE BME C 325 source : BC3 47) chain C residue 56 type sequence E description BINDING SITE FOR RESIDUE SO4 C 323 source : BC4 48) chain C residue 105 type sequence Q description BINDING SITE FOR RESIDUE SO4 C 323 source : BC4 49) chain C residue 108 type sequence K description BINDING SITE FOR RESIDUE SO4 C 323 source : BC4 50) chain C residue 194 type sequence R description BINDING SITE FOR RESIDUE SO4 C 324 source : BC5 51) chain C residue 234 type sequence Y description BINDING SITE FOR RESIDUE SO4 C 324 source : BC5 52) chain C residue 263 type sequence R description BINDING SITE FOR RESIDUE SO4 C 324 source : BC5 53) chain D residue 157 type sequence S description BINDING SITE FOR RESIDUE BME D 326 source : BC6 54) chain D residue 206 type sequence L description BINDING SITE FOR RESIDUE BME D 326 source : BC6 55) chain D residue 215 type sequence M description BINDING SITE FOR RESIDUE BME D 326 source : BC6 56) chain D residue 281 type sequence H description BINDING SITE FOR RESIDUE BME D 326 source : BC6 57) chain D residue 55 type sequence A description BINDING SITE FOR RESIDUE SO4 D 323 source : BC7 58) chain D residue 56 type sequence E description BINDING SITE FOR RESIDUE SO4 D 323 source : BC7 59) chain D residue 105 type sequence Q description BINDING SITE FOR RESIDUE SO4 D 323 source : BC7 60) chain D residue 108 type sequence K description BINDING SITE FOR RESIDUE SO4 D 323 source : BC7 61) chain D residue 194 type sequence R description BINDING SITE FOR RESIDUE SO4 D 324 source : BC8 62) chain D residue 234 type sequence Y description BINDING SITE FOR RESIDUE SO4 D 324 source : BC8 63) chain D residue 263 type sequence R description BINDING SITE FOR RESIDUE SO4 D 324 source : BC8 64) chain D residue 177 type sequence M description BINDING SITE FOR RESIDUE SO4 D 325 source : BC9 65) chain A residue 83-99 type prosite sequence ILYFHGGGYISGSPSTH description LIPASE_GDXG_HIS Lipolytic enzymes "G-D-X-G" family, putative histidine active site. ILyFHGGGYisgSpsTH source prosite : PS01173 66) chain A residue 151-163 type prosite sequence IIIAGDSAGGGLT description LIPASE_GDXG_SER Lipolytic enzymes "G-D-X-G" family, putative serine active site. IiIAGDSAGGgLT source prosite : PS01174

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