eF-site ID 3dnm-A PDB Code 3dnm Chain A click to enlarge Title Crystal Structure Hormone-Sensitive Lipase from a Metagenome Library Classification HYDROLASE Compound Esterase/lipase Source null (Q0GMU1_9BACT) Sequence A:  DTKMDPRDFLQLLKINAEKAEKNLPLDQKRAGMEALCERF PRAEGVELTLTDLGGVPCIRQATDGAGAAHILYFHGGGYI SGSPSTHLVLTTQLAKQSSATLWSLDYRLAPENPFPAAVD DCVAAYRALLKTAGSADRIIIAGDSAGGGLTTASMLKAKE DGLPMPAGLVMLSPFVDLTLSRWSNSNLADRDFLAEPDTL GEMSELYVGGEDRKNPLISPVYADLSGLPEMLIHVGSEEA LLSDSTTLAERAGAAGVSVELKIWPDMPHVFQMYGKFVNA ADISIKEICHWISARIS Description Functional site 1) chain A residue 90 type sequence G description BINDING SITE FOR RESIDUE BME A 325 source : AC1 2) chain A residue 157 type sequence S description BINDING SITE FOR RESIDUE BME A 325 source : AC1 3) chain A residue 206 type sequence L description BINDING SITE FOR RESIDUE BME A 325 source : AC1 4) chain A residue 281 type sequence H description BINDING SITE FOR RESIDUE BME A 325 source : AC1 5) chain A residue 55 type sequence A description BINDING SITE FOR RESIDUE SO4 A 323 source : AC2 6) chain A residue 56 type sequence E description BINDING SITE FOR RESIDUE SO4 A 323 source : AC2 7) chain A residue 105 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 323 source : AC2 8) chain A residue 108 type sequence K description BINDING SITE FOR RESIDUE SO4 A 323 source : AC2 9) chain A residue 194 type sequence R description BINDING SITE FOR RESIDUE SO4 A 324 source : AC3 10) chain A residue 234 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 324 source : AC3 11) chain A residue 263 type sequence R description BINDING SITE FOR RESIDUE SO4 A 324 source : AC3 12) chain A residue 258 type sequence T description BINDING SITE FOR RESIDUE SO4 B 324 source : AC6 13) chain A residue 259 type sequence T description BINDING SITE FOR RESIDUE SO4 B 324 source : AC6 14) chain A residue 262 type sequence E description BINDING SITE FOR RESIDUE SO4 B 324 source : AC6 15) chain A residue 83-99 type prosite sequence ILYFHGGGYISGSPSTH description LIPASE_GDXG_HIS Lipolytic enzymes "G-D-X-G" family, putative histidine active site. ILyFHGGGYisgSpsTH source prosite : PS01173 16) chain A residue 151-163 type prosite sequence IIIAGDSAGGGLT description LIPASE_GDXG_SER Lipolytic enzymes "G-D-X-G" family, putative serine active site. IiIAGDSAGGgLT source prosite : PS01174

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