eF-site ID 3dkn-ABCDEF PDB Code 3dkn Chain A, B, C, D, E, F click to enlarge Title Sec61 in the Canine ribosome-channel complex from the endoplasmic reticulum Classification protein transport/RNA Compound RNA (5'-R(P*CP*GP*UP*GP*CP*CP*AP*AP*GP*CP*UP*GP*CP*GP*AP*UP*AP*AP*GP*C)-3') Source ORGANISM_SCIENTIFIC: Canis lupus familiaris; Sequence A:  KKLIPILEKIPEVELPVKEITFKEKLKWTGIVLVLYFIMG CIDVYTAGAQIPAIFEFWQTITASRIGTLITLGIGPIVTA GIIMQLLVGSGIIQMDLSIPENRALFQGCQKLLSIIMCFV EAVLFVGAGAFGILTPLLAFLVIIQIAFGSIILIYLDEIV SKYGIGSGIGLFIAAGVSQTIFVGALGPEGYLWKFLNSLI QGVPNIEYIAPIIGTIIVFLMVVYAECMRVEIPLAHGRIK GAVGKYPIKFVYVSNIPVILAAALFANIQLWGLALYRMGI PILGHYEGGRAVDGIAYYLSTPYGLSSVISDPIHAIVYMI AMIITCVMFGIFWVETTGLDPKSMAKRIGSLGMAIKGFRK SAIEHRLKRYIPPLTVMSSAFVGFLATIANFIGALGGGTG VLLTVSIVYRMYEQLLREKVSELHPAIAKL B:  TDFNQKIEQLKEFIEECRRVWLVLKKPTKDEYLAVAKVTA LGISLLGIIGYIIHVPATYIKGILK C:  ETFSKIRVKPEHVIGVTVAFVIIEAILTYGRF D:  CGUGCCAAGCUGCGAUAAGC E:  AGCCGCACGGAGGCGAA F:  GGGUUCCUCAGCACUGCUGAUCAGCUGAGGGU Description Functional site 1) chain A residue 393-400 type prosite sequence IGALGGGT description HMG_COA_REDUCTASE_2 Hydroxymethylglutaryl-coenzyme A reductases signature 2. IGaLGGGT source prosite : PS00318 2) chain A residue 69-88 type prosite sequence TLITLGIGPIVTAGIIMQLL description SECY_1 Protein secY signature 1. TLItLGIgPIVtAGIIMQLL source prosite : PS00755 3) chain A residue 156-173 type prosite sequence YLDEIVSKYGIGSGIGLF description SECY_2 Protein secY signature 2. YLdEiVSky.GIGSGiGLF source prosite : PS00756 4) chain C residue 31-49 type TRANSMEM sequence EHVIGVTVAFVIIEAILTY description Helical source Swiss-Prot : SWS_FT_FI1 5) chain A residue 169-191 type TRANSMEM sequence GIGLFIAAGVSQTIFVGALGPEG description Helical; Name=Helix 5 source Swiss-Prot : SWS_FT_FI10 6) chain A residue 210-227 type TRANSMEM sequence IAPIIGTIIVFLMVVYAE description Helical; Name=Helix 6 source Swiss-Prot : SWS_FT_FI11 7) chain A residue 256-277 type TRANSMEM sequence NIPVILAAALFANIQLWGLALY description Helical; Name=Helix 7 source Swiss-Prot : SWS_FT_FI12 8) chain A residue 313-331 type TRANSMEM sequence PIHAIVYMIAMIITCVMFG description Helical; Name=Helix 8 source Swiss-Prot : SWS_FT_FI13 9) chain A residue 383-397 type TRANSMEM sequence VGFLATIANFIGALG description Helical; Name=Helix 9 source Swiss-Prot : SWS_FT_FI14 10) chain A residue 399-412 type TRANSMEM sequence GTGVLLTVSIVYRM description Helical; Name=Helix 10 source Swiss-Prot : SWS_FT_FI15 11) chain A residue 75 type SITE sequence I description Pore ring source Swiss-Prot : SWS_FT_FI16 12) chain A residue 79 type SITE sequence V description Pore ring source Swiss-Prot : SWS_FT_FI16 13) chain A residue 174 type SITE sequence I description Pore ring source Swiss-Prot : SWS_FT_FI16 14) chain A residue 179 type SITE sequence S description Pore ring source Swiss-Prot : SWS_FT_FI16 15) chain A residue 260 type SITE sequence I description Pore ring source Swiss-Prot : SWS_FT_FI16 16) chain A residue 406 type SITE sequence V description Pore ring source Swiss-Prot : SWS_FT_FI16 17) chain A residue 47-55 type TOPO_DOM sequence TAGAQIPAI description Extracellular source Swiss-Prot : SWS_FT_FI2 18) chain A residue 130-140 type TOPO_DOM sequence GAFGILTPLLA description Extracellular source Swiss-Prot : SWS_FT_FI2 19) chain A residue 192-209 type TOPO_DOM sequence YLWKFLNSLIQGVPNIEY description Extracellular source Swiss-Prot : SWS_FT_FI2 20) chain A residue 278-312 type TOPO_DOM sequence RMGIPILGHYEGGRAVDGIAYYLSTPYGLSSVISD description Extracellular source Swiss-Prot : SWS_FT_FI2 21) chain A residue 398 type TOPO_DOM sequence G description Extracellular source Swiss-Prot : SWS_FT_FI2 22) chain A residue 56-88 type TRANSMEM sequence FEFWQTITASRIGTLITLGIGPIVTAGIIMQLL description Discontinuously helical; Name=Helix 2 source Swiss-Prot : SWS_FT_FI3 23) chain A residue 56-63 type INTRAMEM sequence FEFWQTIT description Helical; Name=Helix 2A source Swiss-Prot : SWS_FT_FI4 24) chain A residue 64-69 type INTRAMEM sequence ASRIGT description source Swiss-Prot : SWS_FT_FI5 25) chain A residue 70-88 type INTRAMEM sequence LITLGIGPIVTAGIIMQLL description Helical; Name=Helix 2B source Swiss-Prot : SWS_FT_FI6 26) chain A residue 89-110 type TOPO_DOM sequence VGSGIIQMDLSIPENRALFQGC description Cytoplasmic source Swiss-Prot : SWS_FT_FI7 27) chain A residue 162-168 type TOPO_DOM sequence SKYGIGS description Cytoplasmic source Swiss-Prot : SWS_FT_FI7 28) chain A residue 228-255 type TOPO_DOM sequence CMRVEIPLAHGRIKGAVGKYPIKFVYVS description Cytoplasmic source Swiss-Prot : SWS_FT_FI7 29) chain A residue 332-382 type TOPO_DOM sequence IFWVETTGLDPKSMAKRIGSLGMAIKGFRKSAIEHRLKRY IPPLTVMSSAF description Cytoplasmic source Swiss-Prot : SWS_FT_FI7 30) chain A residue 111-129 type TRANSMEM sequence QKLLSIIMCFVEAVLFVGA description Helical; Name=Helix 3 source Swiss-Prot : SWS_FT_FI8 31) chain A residue 141-161 type TRANSMEM sequence FLVIIQIAFGSIILIYLDEIV description Helical; Name=Helix 4 source Swiss-Prot : SWS_FT_FI9

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