eF-site ID 3djt-A
PDB Code 3djt
Chain A

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Title Crystal structure of transthyretin variant V30M at acidic pH
Classification TRANSPORT PROTEIN
Compound Transthyretin
Source Homo sapiens (Human) (TTHY_HUMAN)
Sequence A:  CPLMVKVLDAVRGSPAINVAMHVFRKAADDTWEPFASGKT
SESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHE
HAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNP
Description


Functional site

1) chain A
residue 105-117
type prosite
sequence YTIAALLSPYSYS
description TRANSTHYRETIN_2 Transthyretin signature 2. YTIAalLSPYSYS
source prosite : PS00769

2) chain A
residue 98
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19167329
source Swiss-Prot : SWS_FT_FI5

3) chain A
residue 15
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:11418763, ECO:0007744|PDB:1ICT
source Swiss-Prot : SWS_FT_FI1

4) chain A
residue 54
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:11418763, ECO:0007744|PDB:1ICT
source Swiss-Prot : SWS_FT_FI1

5) chain A
residue 117
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:11418763, ECO:0007744|PDB:1ICT
source Swiss-Prot : SWS_FT_FI1

6) chain A
residue 10
type MOD_RES
sequence C
description Sulfocysteine => ECO:0000269|PubMed:17175208, ECO:0007744|PDB:2H4E
source Swiss-Prot : SWS_FT_FI2

7) chain A
residue 42
type MOD_RES
sequence E
description 4-carboxyglutamate; in a patient with Moyamoya disease => ECO:0000269|PubMed:18221012
source Swiss-Prot : SWS_FT_FI3

8) chain A
residue 52
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P02767
source Swiss-Prot : SWS_FT_FI4


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