eF-site ID 3dbs-A PDB Code 3dbs Chain A click to enlarge Title Structure of PI3K gamma in complex with GDC0941 Classification TRANSFERASE Compound Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Source ORGANISM_COMMON: Human; ORGANISM_SCIENTIFIC: Homo sapiens; Sequence A:  MSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVT PRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFI VIHRSTTSQTIKVSPDDTPGAILQSFFTKMAEQDFVLRVC GRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPAL DEVRKEECDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQH GQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALL NLQIYCLLYYVNLLLIDHRFLLRRGEYVLHMWQISGFNAD KLTSATNPDKENSMSISILLDNHPIARAEMPNQLRKQLEA IIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVK WGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSD ENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSAL ARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVIL EAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKY DVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALA IEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDD LRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIG MIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPT EEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITET GNLFHIDFGHERVPFVLTPDFLFVMGTSGKKTSPHFQKFQ DICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEY IRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHL V Description Functional site 1) chain A residue 802 type sequence K description BINDING SITE FOR RESIDUE GD9 A 1 source : AC1 2) chain A residue 804 type sequence M description BINDING SITE FOR RESIDUE GD9 A 1 source : AC1 3) chain A residue 805 type sequence A description BINDING SITE FOR RESIDUE GD9 A 1 source : AC1 4) chain A residue 831 type sequence I description BINDING SITE FOR RESIDUE GD9 A 1 source : AC1 5) chain A residue 833 type sequence K description BINDING SITE FOR RESIDUE GD9 A 1 source : AC1 6) chain A residue 836 type sequence D description BINDING SITE FOR RESIDUE GD9 A 1 source : AC1 7) chain A residue 841 type sequence D description BINDING SITE FOR RESIDUE GD9 A 1 source : AC1 8) chain A residue 867 type sequence Y description BINDING SITE FOR RESIDUE GD9 A 1 source : AC1 9) chain A residue 879 type sequence I description BINDING SITE FOR RESIDUE GD9 A 1 source : AC1 10) chain A residue 880 type sequence E description BINDING SITE FOR RESIDUE GD9 A 1 source : AC1 11) chain A residue 881 type sequence I description BINDING SITE FOR RESIDUE GD9 A 1 source : AC1 12) chain A residue 887 type sequence T description BINDING SITE FOR RESIDUE GD9 A 1 source : AC1 13) chain A residue 953 type sequence M description BINDING SITE FOR RESIDUE GD9 A 1 source : AC1 14) chain A residue 963 type sequence I description BINDING SITE FOR RESIDUE GD9 A 1 source : AC1 15) chain A residue 964 type sequence D description BINDING SITE FOR RESIDUE GD9 A 1 source : AC1 16) chain A residue 829 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 864 type BINDING sequence L description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 961 type BINDING sequence F description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 1024 type MOD_RES sequence T description Phosphothreonine; by PKA => ECO:0000250|UniProtKB:Q9JHG7 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 832-846 type prosite sequence FKHGDDLRQDMLILQ description PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKhg.DDLRQDmlilQ source prosite : PS00915 21) chain A residue 931-951 type prosite sequence SCAGYCVATFVLGIGDRHNDN description PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatFVLgIgDRHndN source prosite : PS00916

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