eF-site ID 3d8c-AB PDB Code 3d8c Chain A, B click to enlarge Title Factor inhibiting HIF-1 alpha D201G mutant in complex with ZN(II), alpha-ketoglutarate and HIF-1 alpha 19mer Classification TRANSCRIPTION REGULATOR, OXIDOREDUCTASE Compound Hypoxia-inducible factor 1 alpha inhibitor Source null (3D8C) Sequence A:  VASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQS DPRAEELIENEEPVVLTDTNLVYPALKWDLEYLQENIGNG DFSVYSASTHKFLYYDEKKMANFQNFKPRSNREEMKFHEF VEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWN WINKQQGKRGWGQLTSNLLLIGMEGNVTPAHYGEQQNFFA QIKGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPD YERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGG ITITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGE ALGNPQEVGPLLNTMIKGRYN B:  QLTSYDCEVNAPI Description Functional site 1) chain A residue 199 type sequence H description BINDING SITE FOR RESIDUE ZN A 350 source : AC1 2) chain A residue 279 type sequence H description BINDING SITE FOR RESIDUE ZN A 350 source : AC1 3) chain A residue 138 type sequence R description BINDING SITE FOR RESIDUE SO4 A 501 source : AC2 4) chain A residue 140 type sequence G description BINDING SITE FOR RESIDUE SO4 A 501 source : AC2 5) chain A residue 141 type sequence E description BINDING SITE FOR RESIDUE SO4 A 501 source : AC2 6) chain A residue 142 type sequence E description BINDING SITE FOR RESIDUE SO4 A 501 source : AC2 7) chain A residue 143 type sequence R description BINDING SITE FOR RESIDUE SO4 A 502 source : AC3 8) chain A residue 192 type sequence E description BINDING SITE FOR RESIDUE SO4 A 502 source : AC3 9) chain A residue 193 type sequence G description BINDING SITE FOR RESIDUE SO4 A 502 source : AC3 10) chain A residue 285 type sequence L description BINDING SITE FOR RESIDUE SO4 A 502 source : AC3 11) chain A residue 286 type sequence N description BINDING SITE FOR RESIDUE SO4 A 502 source : AC3 12) chain A residue 145 type sequence Y description BINDING SITE FOR RESIDUE AKG A 1351 source : AC4 13) chain A residue 196 type sequence T description BINDING SITE FOR RESIDUE AKG A 1351 source : AC4 14) chain A residue 199 type sequence H description BINDING SITE FOR RESIDUE AKG A 1351 source : AC4 15) chain A residue 205 type sequence N description BINDING SITE FOR RESIDUE AKG A 1351 source : AC4 16) chain A residue 207 type sequence F description BINDING SITE FOR RESIDUE AKG A 1351 source : AC4 17) chain A residue 214 type sequence K description BINDING SITE FOR RESIDUE AKG A 1351 source : AC4 18) chain A residue 279 type sequence H description BINDING SITE FOR RESIDUE AKG A 1351 source : AC4 19) chain A residue 281 type sequence I description BINDING SITE FOR RESIDUE AKG A 1351 source : AC4 20) chain A residue 294 type sequence N description BINDING SITE FOR RESIDUE AKG A 1351 source : AC4 21) chain A residue 296 type sequence W description BINDING SITE FOR RESIDUE AKG A 1351 source : AC4 22) chain A residue 99 type sequence K description BINDING SITE FOR RESIDUE GOL A 2000 source : AC5 23) chain A residue 230 type sequence Y description BINDING SITE FOR RESIDUE GOL A 2000 source : AC5 24) chain A residue 240 type sequence S description BINDING SITE FOR RESIDUE GOL A 2000 source : AC5 25) chain A residue 241 type sequence Q description BINDING SITE FOR RESIDUE GOL A 2000 source : AC5 26) chain A residue 243 type sequence D description BINDING SITE FOR RESIDUE GOL A 2000 source : AC5 27) chain A residue 145 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 28) chain A residue 196 type BINDING sequence T description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 29) chain A residue 205 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 30) chain A residue 214 type BINDING sequence K description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 31) chain A residue 294 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 32) chain A residue 152 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 33) chain A residue 181 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 34) chain A residue 238 type BINDING sequence R description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 35) chain A residue 300 type BINDING sequence A description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 36) chain A residue 321 type BINDING sequence N description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 37) chain A residue 199 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:15913349, ECO:0000269|PubMed:17135241, ECO:0000269|PubMed:20396966, ECO:0000269|PubMed:20822901, ECO:0000269|PubMed:21251231, ECO:0000269|PubMed:21460794 source Swiss-Prot : SWS_FT_FI3 38) chain A residue 201 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:15913349, ECO:0000269|PubMed:17135241, ECO:0000269|PubMed:20396966, ECO:0000269|PubMed:20822901, ECO:0000269|PubMed:21251231, ECO:0000269|PubMed:21460794 source Swiss-Prot : SWS_FT_FI3 39) chain A residue 279 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:15913349, ECO:0000269|PubMed:17135241, ECO:0000269|PubMed:20396966, ECO:0000269|PubMed:20822901, ECO:0000269|PubMed:21251231, ECO:0000269|PubMed:21460794 source Swiss-Prot : SWS_FT_FI3 40) chain A residue 340 type SITE sequence L description Important for dimer formation source Swiss-Prot : SWS_FT_FI4

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