eF-site ID 3d5w-A PDB Code 3d5w Chain A click to enlarge Title Crystal structure of a phosphorylated Polo-like kinase 1 (Plk1) catalytic domain in complex with ADP. Classification TRANSFERASE Compound Polo-like kinase 1 Source Danio rerio (Zebrafish) (Brachydanio rerio) (Q4KMI8_DANRE) Sequence A:  KEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEITDMDTKE VFAGKVVPKSMLPHQKEKMSTEIAIHKSLDNPHVVGFHGF FEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQ TIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLAT KIEFDGERKKXLCGTPNYIAPEVLCKKGHSFEVDIWSLGC ILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHINPVAS ALIRRMLHADPTLRPSVAELLTDEFFTSGYAPMRLPTSCL TVPPR Description Functional site 1) chain A residue 45 type sequence L description BINDING SITE FOR RESIDUE ADP A 313 source : AC1 2) chain A residue 47 type sequence K description BINDING SITE FOR RESIDUE ADP A 313 source : AC1 3) chain A residue 49 type sequence G description BINDING SITE FOR RESIDUE ADP A 313 source : AC1 4) chain A residue 51 type sequence A description BINDING SITE FOR RESIDUE ADP A 313 source : AC1 5) chain A residue 66 type sequence A description BINDING SITE FOR RESIDUE ADP A 313 source : AC1 6) chain A residue 117 type sequence E description BINDING SITE FOR RESIDUE ADP A 313 source : AC1 7) chain A residue 119 type sequence C description BINDING SITE FOR RESIDUE ADP A 313 source : AC1 8) chain A residue 122 type sequence R description BINDING SITE FOR RESIDUE ADP A 313 source : AC1 9) chain A residue 169 type sequence F description BINDING SITE FOR RESIDUE ADP A 313 source : AC1 10) chain A residue 180 type sequence D description BINDING SITE FOR RESIDUE ADP A 313 source : AC1 11) chain A residue 45-68 type prosite sequence LGKGGFAKCYEITDMDTKEVFAGK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGGFAKCYeItdmdtkev..........FAGK source prosite : PS00107 12) chain A residue 158-170 type prosite sequence VIHRDLKLGNLFL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDLKlgNLFL source prosite : PS00108

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