|
|
eF-site ID
|
3d09-A |
|
PDB Code
|
3d09 |
|
Chain
|
A |
|
click to enlarge
|
|
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Title
|
Human p53 core domain with hot spot mutation R249S and second-site suppressor mutations H168R and T123A |
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Classification
|
TRANSCRIPTION |
|
Compound
|
Cellular tumor antigen p53 |
|
Source
|
Homo sapiens (Human) (P53_HUMAN) |
|
|
Sequence
|
A: |
SVPSQKTYQGSYGFRLGFLHSVACTYSPALNKMFCQLAKT
CPVQLWVDSTPPPGTRVRAMAIYKQSQRMTEVVRRCPHHE
RCSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEP
PEVGSDCTTIHYNYMCNSSCMGGMNRSPILTIITLEDSSG
NLLGRNSFEVRVCACPGRDRRTEEENLR
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Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
176 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN A 1
|
| source |
: AC1
|
|
|
2)
|
chain |
A |
| residue |
179 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN A 1
|
| source |
: AC1
|
|
|
3)
|
chain |
A |
| residue |
238 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN A 1
|
| source |
: AC1
|
|
|
4)
|
chain |
A |
| residue |
242 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN A 1
|
| source |
: AC1
|
|
|
5)
|
chain |
A |
| residue |
269 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
6)
|
chain |
A |
| residue |
284 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine; by AURKB => ECO:0000269|PubMed:20959462
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
7)
|
chain |
A |
| residue |
176 |
| type |
BINDING |
| sequence |
C
|
| description |
BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
A |
| residue |
179 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
9)
|
chain |
A |
| residue |
238 |
| type |
BINDING |
| sequence |
C
|
| description |
BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
10)
|
chain |
A |
| residue |
242 |
| type |
BINDING |
| sequence |
C
|
| description |
BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|