eF-site ID 3cv7-A
PDB Code 3cv7
Chain A

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Title Crystal structure of porcine aldehyde reductase ternary complex
Classification OXIDOREDUCTASE
Compound Alcohol dehydrogenase
Source ORGANISM_COMMON: pig; ORGANISM_SCIENTIFIC: Sus scrofa;
Sequence A:  MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAIKYALTVG
YRHIDCAAIYGNELEIGEALQETVGPGKAVPREELFVTSK
LWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER
GDNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALG
LSNFSSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHC
QARGLEVTAYSPLGSSDRAWRDPNEPVLLEEPVVQALAEK
YNRSPAQILLRWQVQRKVICIPKSVTPSRILQNIQVFDFT
FSPEEMKQLDALNKNLRFIVPMLTVDVPRDAGHPLYPFND
PY
Description


Functional site

1) chain A
residue 251
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 361
source : AC1

2) chain A
residue 277
type
sequence F
description BINDING SITE FOR RESIDUE SO4 A 361
source : AC1

3) chain A
residue 167
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 362
source : AC2

4) chain A
residue 243
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 362
source : AC2

5) chain A
residue 275
type
sequence Q
description BINDING SITE FOR RESIDUE SO4 A 362
source : AC2

6) chain A
residue 5
type
sequence C
description BINDING SITE FOR RESIDUE SO4 A 363
source : AC3

7) chain A
residue 7
type
sequence L
description BINDING SITE FOR RESIDUE SO4 A 363
source : AC3

8) chain A
residue 13
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A 363
source : AC3

9) chain A
residue 303
type
sequence L
description BINDING SITE FOR RESIDUE SO4 A 364
source : AC4

10) chain A
residue 304
type
sequence T
description BINDING SITE FOR RESIDUE SO4 A 364
source : AC4

11) chain A
residue 20
type
sequence G
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

12) chain A
residue 21
type
sequence T
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

13) chain A
residue 22
type
sequence W
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

14) chain A
residue 45
type
sequence D
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

15) chain A
residue 50
type
sequence Y
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

16) chain A
residue 80
type
sequence K
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

17) chain A
residue 113
type
sequence H
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

18) chain A
residue 162
type
sequence S
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

19) chain A
residue 163
type
sequence N
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

20) chain A
residue 184
type
sequence Q
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

21) chain A
residue 210
type
sequence Y
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

22) chain A
residue 211
type
sequence S
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

23) chain A
residue 212
type
sequence P
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

24) chain A
residue 213
type
sequence L
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

25) chain A
residue 214
type
sequence G
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

26) chain A
residue 215
type
sequence S
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

27) chain A
residue 217
type
sequence D
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

28) chain A
residue 246
type
sequence A
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

29) chain A
residue 261
type
sequence I
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

30) chain A
residue 262
type
sequence P
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

31) chain A
residue 263
type
sequence K
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

32) chain A
residue 264
type
sequence S
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

33) chain A
residue 266
type
sequence T
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

34) chain A
residue 269
type
sequence R
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

35) chain A
residue 272
type
sequence Q
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

36) chain A
residue 273
type
sequence N
description BINDING SITE FOR RESIDUE NAP A 370
source : AC5

37) chain A
residue 22
type
sequence W
description BINDING SITE FOR RESIDUE C2U A 371
source : AC6

38) chain A
residue 49
type
sequence I
description BINDING SITE FOR RESIDUE C2U A 371
source : AC6

39) chain A
residue 50
type
sequence Y
description BINDING SITE FOR RESIDUE C2U A 371
source : AC6

40) chain A
residue 82
type
sequence W
description BINDING SITE FOR RESIDUE C2U A 371
source : AC6

41) chain A
residue 113
type
sequence H
description BINDING SITE FOR RESIDUE C2U A 371
source : AC6

42) chain A
residue 114
type
sequence W
description BINDING SITE FOR RESIDUE C2U A 371
source : AC6

43) chain A
residue 312
type
sequence R
description BINDING SITE FOR RESIDUE C2U A 371
source : AC6

44) chain A
residue 50
type ACT_SITE
sequence Y
description Proton donor => ECO:0000269|PubMed:7552731
source Swiss-Prot : SWS_FT_FI1

45) chain A
residue 11
type BINDING
sequence G
description BINDING => ECO:0000255
source Swiss-Prot : SWS_FT_FI2

46) chain A
residue 21
type BINDING
sequence T
description BINDING => ECO:0000250|UniProtKB:O60218
source Swiss-Prot : SWS_FT_FI3

47) chain A
residue 45
type BINDING
sequence D
description BINDING => ECO:0000250|UniProtKB:O60218
source Swiss-Prot : SWS_FT_FI3

48) chain A
residue 162
type BINDING
sequence S
description BINDING => ECO:0000250|UniProtKB:O60218
source Swiss-Prot : SWS_FT_FI3

49) chain A
residue 184
type BINDING
sequence Q
description BINDING => ECO:0000250|UniProtKB:O60218
source Swiss-Prot : SWS_FT_FI3

50) chain A
residue 113
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:7552731
source Swiss-Prot : SWS_FT_FI4

51) chain A
residue 211
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:7552731
source Swiss-Prot : SWS_FT_FI4

52) chain A
residue 80
type SITE
sequence K
description Lowers pKa of active site Tyr => ECO:0000250|UniProtKB:P14550
source Swiss-Prot : SWS_FT_FI5

53) chain A
residue 2
type MOD_RES
sequence A
description N-acetylalanine => ECO:0000250|UniProtKB:P14550
source Swiss-Prot : SWS_FT_FI6

54) chain A
residue 4
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P51635
source Swiss-Prot : SWS_FT_FI7

55) chain A
residue 127
type MOD_RES
sequence K
description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9JII6
source Swiss-Prot : SWS_FT_FI8

56) chain A
residue 147-164
type prosite
sequence LEALVAKGLVRALGLSNF
description ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. LealvakglVRALGLSNF
source prosite : PS00062

57) chain A
residue 261-276
type prosite
sequence IPKSVTPSRILQNIQV
description ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. IPKSVTpsRIlQNiQV
source prosite : PS00063

58) chain A
residue 40-57
type prosite
sequence GYRHIDCAAIYGNELEIG
description ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHIDCAaiygnEleIG
source prosite : PS00798

59) chain A
residue 211
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P14550
source Swiss-Prot : SWS_FT_FI10

60) chain A
residue 145
type MOD_RES
sequence K
description N6-succinyllysine => ECO:0000250|UniProtKB:Q9JII6
source Swiss-Prot : SWS_FT_FI9


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