eF-site ID 3ctz-A PDB Code 3ctz Chain A click to enlarge Title Structure of human cytosolic X-prolyl aminopeptidase Classification HYDROLASE Compound Xaa-Pro aminopeptidase 1 Source Homo sapiens (Human) (XPP1_HUMAN) Sequence A:  PKVTSELLRQLRQAMRNSEYVTEPIQAYIIPSGDAHQSEY IAPCDCRRAFVSGFDGSAGTAIITEEHAAMWTDGRYFLQA AKQMDSNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVDPL IIPTDYWKKMAKVLRSAGHHLIPVKENLVDKIWTDRPERP CKPLLTLGLDYTGISWKDKVADLRLKMAERNVMWFVVTAL DEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLFIDGDRI DAPSVKEHLLLDLGLEAEYRIQVHPYKSILSELKALCADL SPREKVWVSDKASYAVSETIPKDHRCCMPYTPICIAKAVK NSAESEGMRRAHIKDAVALCELFNWLEKEVPKGGVTEISA ADKAEEFRRQQADFVDLSFPTISSTGPTGAIIHYAPVPET NRTLSLDEVYLIDSGAQYKDGTTDVTRTMHFETPTAYEKE CFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSGLD YLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTD EPGYYEDGAFGIRIENVVLVVPVKTKYNFNNRGSLTLEPL TLVPIQTKMIDVDSLTDKECDWLNNYHLTCRDVIGKELQK QGRQEALEWLIRETQPI Description Functional site 1) chain A residue 426 type sequence D description BINDING SITE FOR RESIDUE MN A 624 source : AC1 2) chain A residue 489 type sequence H description BINDING SITE FOR RESIDUE MN A 624 source : AC1 3) chain A residue 523 type sequence E description BINDING SITE FOR RESIDUE MN A 624 source : AC1 4) chain A residue 537 type sequence E description BINDING SITE FOR RESIDUE MN A 624 source : AC1 5) chain A residue 381 type sequence F description BINDING SITE FOR RESIDUE MN A 625 source : AC2 6) chain A residue 415 type sequence D description BINDING SITE FOR RESIDUE MN A 625 source : AC2 7) chain A residue 426 type sequence D description BINDING SITE FOR RESIDUE MN A 625 source : AC2 8) chain A residue 428 type sequence T description BINDING SITE FOR RESIDUE MN A 625 source : AC2 9) chain A residue 537 type sequence E description BINDING SITE FOR RESIDUE MN A 625 source : AC2 10) chain A residue 281 type sequence D description BINDING SITE FOR RESIDUE CA A 626 source : AC3 11) chain A residue 435 type sequence T description BINDING SITE FOR RESIDUE CA A 626 source : AC3 12) chain A residue 486 type sequence G description BINDING SITE FOR RESIDUE NA A 627 source : AC4 13) chain A residue 507 type sequence K description BINDING SITE FOR RESIDUE NA A 627 source : AC4 14) chain A residue 381 type sequence F description BINDING SITE FOR RESIDUE P6G A 628 source : AC5 15) chain A residue 394 type sequence I description BINDING SITE FOR RESIDUE P6G A 628 source : AC5 16) chain A residue 395 type sequence H description BINDING SITE FOR RESIDUE P6G A 628 source : AC5 17) chain A residue 485 type sequence H description BINDING SITE FOR RESIDUE P6G A 628 source : AC5 18) chain A residue 486 type sequence G description BINDING SITE FOR RESIDUE P6G A 628 source : AC5 19) chain A residue 489 type sequence H description BINDING SITE FOR RESIDUE P6G A 628 source : AC5 20) chain A residue 498 type sequence H description BINDING SITE FOR RESIDUE P6G A 628 source : AC5 21) chain A residue 523 type sequence E description BINDING SITE FOR RESIDUE P6G A 628 source : AC5 22) chain A residue 77 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:O44750 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 395 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O44750 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 498 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O44750 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 415 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18515364, ECO:0007744|PDB:3CTZ source Swiss-Prot : SWS_FT_FI2 26) chain A residue 426 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18515364, ECO:0007744|PDB:3CTZ source Swiss-Prot : SWS_FT_FI2 27) chain A residue 489 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18515364, ECO:0007744|PDB:3CTZ source Swiss-Prot : SWS_FT_FI2 28) chain A residue 523 type BINDING sequence E description BINDING => ECO:0000269|PubMed:18515364, ECO:0007744|PDB:3CTZ source Swiss-Prot : SWS_FT_FI2 29) chain A residue 537 type BINDING sequence E description BINDING => ECO:0000269|PubMed:18515364, ECO:0007744|PDB:3CTZ source Swiss-Prot : SWS_FT_FI2 30) chain A residue 485-497 type prosite sequence HGTGHGVGSFLNV description PROLINE_PEPTIDASE Aminopeptidase P and proline dipeptidase signature. HGTGHgVGSfLNV source prosite : PS00491 31) chain A residue 304 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3

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