eF-site ID 3cst-A
PDB Code 3cst
Chain A

click to enlarge
Title Crystal structure of PI3K p110gamma catalytical domain in complex with organoruthenium inhibitor E5E2
Classification TRANSFERASE
Compound Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Source Homo sapiens (Human) (PK3CG_HUMAN)
Sequence A:  MSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVT
PRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFI
VIHRSTTSQTIKVSPDDTPGAILQSFFTKMAEQDFVLRVC
GRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPAL
DEVRKEECDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQH
GQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALL
NLQIYCLLYYVNLLLIDHRFLLRRGEYVLHMWQISGFNAD
KLTSATNPDKENSMSISILLDNHPIARAEMPNQLRKQLEA
IIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVK
WGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSD
ENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSAL
ARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVIL
EAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKY
DVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALA
IEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDD
LRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIG
MIEIVKDATTIAKIQQSTVGNTGFKDEVLNHWLKEKSPTE
EKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETG
NLFHIDFGHERVPFVLTPDFLFVMGTSGKKTSPHFQKFQD
ICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYI
RDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWF
Description


Functional site

1) chain A
residue 804
type
sequence M
description BINDING SITE FOR RESIDUE E52 A 1
source : AC1

2) chain A
residue 805
type
sequence A
description BINDING SITE FOR RESIDUE E52 A 1
source : AC1

3) chain A
residue 812
type
sequence W
description BINDING SITE FOR RESIDUE E52 A 1
source : AC1

4) chain A
residue 880
type
sequence E
description BINDING SITE FOR RESIDUE E52 A 1
source : AC1

5) chain A
residue 883
type
sequence K
description BINDING SITE FOR RESIDUE E52 A 1
source : AC1

6) chain A
residue 884
type
sequence D
description BINDING SITE FOR RESIDUE E52 A 1
source : AC1

7) chain A
residue 885
type
sequence A
description BINDING SITE FOR RESIDUE E52 A 1
source : AC1

8) chain A
residue 887
type
sequence T
description BINDING SITE FOR RESIDUE E52 A 1
source : AC1

9) chain A
residue 890
type
sequence K
description BINDING SITE FOR RESIDUE E52 A 1
source : AC1

10) chain A
residue 953
type
sequence M
description BINDING SITE FOR RESIDUE E52 A 1
source : AC1

11) chain A
residue 829
type BINDING
sequence G
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

12) chain A
residue 864
type BINDING
sequence L
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

13) chain A
residue 961
type BINDING
sequence F
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

14) chain A
residue 832-846
type prosite
sequence FKHGDDLRQDMLILQ
description PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKhg.DDLRQDmlilQ
source prosite : PS00915

15) chain A
residue 931-951
type prosite
sequence SCAGYCVATFVLGIGDRHNDN
description PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatFVLgIgDRHndN
source prosite : PS00916

16) chain A
residue 1024
type MOD_RES
sequence T
description Phosphothreonine; by PKA => ECO:0000250|UniProtKB:Q9JHG7
source Swiss-Prot : SWS_FT_FI2


Display surface

Download
Links