eF-site ID 3cr0-A PDB Code 3cr0 Chain A click to enlarge Title Wee1 kinase complex with inhibitor PD259_809 Classification TRANSFERASE Compound Wee1-like protein kinase Source null (WEE1_HUMAN) Sequence A:  SRYTTEFHELEKIGSGGSVFKCVKRLDGCIYAIKRSKKPL AGSVDEQNALREVYAHAVLGQHSHVVRYFSAWADHMLIQN EYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRY IHSMSLVHMDIKPSNIFISKVMFKIGDLGHVTRISSPQVE EGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPL PRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPER RPSAMALVKHSVLLSAS Description Functional site 1) chain A residue 429 type sequence P description BINDING SITE FOR RESIDUE CL A 1 source : AC1 2) chain A residue 430 type sequence S description BINDING SITE FOR RESIDUE CL A 1 source : AC1 3) chain A residue 481 type sequence R description BINDING SITE FOR RESIDUE CL A 1 source : AC1 4) chain A residue 305 type sequence I description BINDING SITE FOR RESIDUE 809 A 901 source : AC2 5) chain A residue 306 type sequence G description BINDING SITE FOR RESIDUE 809 A 901 source : AC2 6) chain A residue 326 type sequence A description BINDING SITE FOR RESIDUE 809 A 901 source : AC2 7) chain A residue 328 type sequence K description BINDING SITE FOR RESIDUE 809 A 901 source : AC2 8) chain A residue 346 type sequence E description BINDING SITE FOR RESIDUE 809 A 901 source : AC2 9) chain A residue 376 type sequence N description BINDING SITE FOR RESIDUE 809 A 901 source : AC2 10) chain A residue 377 type sequence E description BINDING SITE FOR RESIDUE 809 A 901 source : AC2 11) chain A residue 379 type sequence C description BINDING SITE FOR RESIDUE 809 A 901 source : AC2 12) chain A residue 382 type sequence G description BINDING SITE FOR RESIDUE 809 A 901 source : AC2 13) chain A residue 463 type sequence D description BINDING SITE FOR RESIDUE 809 A 901 source : AC2 14) chain A residue 388 type sequence I description BINDING SITE FOR RESIDUE GOL A 902 source : AC3 15) chain A residue 391 type sequence N description BINDING SITE FOR RESIDUE GOL A 902 source : AC3 16) chain A residue 392 type sequence Y description BINDING SITE FOR RESIDUE GOL A 902 source : AC3 17) chain A residue 397 type sequence Y description BINDING SITE FOR RESIDUE GOL A 902 source : AC3 18) chain A residue 398 type sequence F description BINDING SITE FOR RESIDUE GOL A 902 source : AC3 19) chain A residue 509 type sequence C description BINDING SITE FOR RESIDUE GOL A 902 source : AC3 20) chain A residue 510 type sequence A description BINDING SITE FOR RESIDUE GOL A 902 source : AC3 21) chain A residue 512 type sequence G description BINDING SITE FOR RESIDUE GOL A 902 source : AC3 22) chain A residue 513 type sequence A description BINDING SITE FOR RESIDUE GOL A 902 source : AC3 23) chain A residue 305-328 type prosite sequence IGSGGSVFKCVKRLDGCIYAIK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGEFGSVFkCvkrldgci..........YAIK source prosite : PS00107 24) chain A residue 463 type BINDING sequence D description BINDING => ECO:0000269|PubMed:15837193 source Swiss-Prot : SWS_FT_FI3 25) chain A residue 465 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15837193 source Swiss-Prot : SWS_FT_FI3 26) chain A residue 431 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15837193 source Swiss-Prot : SWS_FT_FI3 27) chain A residue 342 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15837193 source Swiss-Prot : SWS_FT_FI3 28) chain A residue 426 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 29) chain A residue 305 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 30) chain A residue 328 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 31) chain A residue 307 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 32) chain A residue 312 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI5 33) chain A residue 422-434 type prosite sequence LVHMDIKPSNIFI description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LvHmDIKpsNIFI source prosite : PS00108

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