eF-site ID 3coa-ABCDEF PDB Code 3coa Chain A, B, C, D, E, F click to enlarge Title Crystal Structure of FoxO1 DBD Bound to IRE DNA Classification Transcription/DNA Compound DNA (5'-D(*DTP*DGP*DGP*DTP*DTP*DTP*DGP*DTP*DTP*DTP*DTP*DGP*DCP*DTP*DTP*DG)-3') Source Homo sapiens (Human) (3COA) Sequence A:  TGGTTTGTTTTGCTTG B:  CAAGCAAAACAAACCA C:  RRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVP YFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSS WWMLNP D:  TGGTTTGTTTTGCTTG E:  CAAGCAAAACAAACCA F:  SRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSV PYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKS SWWMLNP Description Functional site 1) chain C residue 217 type sequence L description BINDING SITE FOR RESIDUE CA C 1 source : AC1 2) chain C residue 218 type sequence S description BINDING SITE FOR RESIDUE CA C 1 source : AC1 3) chain C residue 220 type sequence H description BINDING SITE FOR RESIDUE CA C 1 source : AC1 4) chain C residue 223 type sequence F description BINDING SITE FOR RESIDUE CA C 1 source : AC1 5) chain F residue 217 type sequence L description BINDING SITE FOR RESIDUE CA F 2 source : AC2 6) chain F residue 218 type sequence S description BINDING SITE FOR RESIDUE CA F 2 source : AC2 7) chain F residue 220 type sequence H description BINDING SITE FOR RESIDUE CA F 2 source : AC2 8) chain F residue 223 type sequence F description BINDING SITE FOR RESIDUE CA F 2 source : AC2 9) chain C residue 209-215 type prosite sequence WKNSIRH description FORK_HEAD_2 Fork head domain signature 2. WKNSIRH source prosite : PS00658 10) chain C residue 159-235 type DNA_BIND sequence AWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFK DKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSS description Fork-head => ECO:0000255|PROSITE-ProRule:PRU00089 source Swiss-Prot : SWS_FT_FI1 11) chain F residue 159-235 type DNA_BIND sequence AWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFK DKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSS description Fork-head => ECO:0000255|PROSITE-ProRule:PRU00089 source Swiss-Prot : SWS_FT_FI1 12) chain C residue 212 type MOD_RES sequence S description Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:18786403, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:21245099 source Swiss-Prot : SWS_FT_FI3 13) chain F residue 212 type MOD_RES sequence S description Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:18786403, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:21245099 source Swiss-Prot : SWS_FT_FI3 14) chain C residue 218 type MOD_RES sequence S description Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:18786403 source Swiss-Prot : SWS_FT_FI4 15) chain C residue 234 type MOD_RES sequence S description Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:18786403 source Swiss-Prot : SWS_FT_FI4 16) chain C residue 235 type MOD_RES sequence S description Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:18786403 source Swiss-Prot : SWS_FT_FI4 17) chain F residue 218 type MOD_RES sequence S description Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:18786403 source Swiss-Prot : SWS_FT_FI4 18) chain F residue 234 type MOD_RES sequence S description Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:18786403 source Swiss-Prot : SWS_FT_FI4 19) chain F residue 235 type MOD_RES sequence S description Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:18786403 source Swiss-Prot : SWS_FT_FI4 20) chain C residue 158 type SITE sequence N description DNA-binding => ECO:0000269|PubMed:18786403 source Swiss-Prot : SWS_FT_FI2 21) chain C residue 165 type SITE sequence Y description DNA-binding => ECO:0000269|PubMed:18786403 source Swiss-Prot : SWS_FT_FI2 22) chain C residue 225 type SITE sequence R description DNA-binding => ECO:0000269|PubMed:18786403 source Swiss-Prot : SWS_FT_FI2 23) chain F residue 158 type SITE sequence N description DNA-binding => ECO:0000269|PubMed:18786403 source Swiss-Prot : SWS_FT_FI2 24) chain F residue 165 type SITE sequence Y description DNA-binding => ECO:0000269|PubMed:18786403 source Swiss-Prot : SWS_FT_FI2 25) chain F residue 225 type SITE sequence R description DNA-binding => ECO:0000269|PubMed:18786403 source Swiss-Prot : SWS_FT_FI2

Display surface Download Links