eF-site ID 3co6-C PDB Code 3co6 Chain C click to enlarge Title Crystal Structure of FoxO1 DBD Bound to DBE1 DNA Classification Transcription/DNA Compound DNA (5'-D(*DTP*DGP*DGP*DTP*DTP*DTP*DGP*DTP*DTP*DTP*DAP*DCP*DCP*DTP*DTP*DG)-3') Source Homo sapiens (Human) (3CO6) Sequence C:  SSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKS VPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGK SSWWMLNPEGG Description Functional site 1) chain C residue 217 type sequence L description BINDING SITE FOR RESIDUE CA C 2 source : AC2 2) chain C residue 218 type sequence S description BINDING SITE FOR RESIDUE CA C 2 source : AC2 3) chain C residue 220 type sequence H description BINDING SITE FOR RESIDUE CA C 2 source : AC2 4) chain C residue 223 type sequence F description BINDING SITE FOR RESIDUE CA C 2 source : AC2 5) chain C residue 159-235 type DNA_BIND sequence AWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFK DKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSS description Fork-head => ECO:0000255|PROSITE-ProRule:PRU00089 source Swiss-Prot : SWS_FT_FI1 6) chain C residue 158 type SITE sequence N description DNA-binding => ECO:0000269|PubMed:18786403 source Swiss-Prot : SWS_FT_FI2 7) chain C residue 165 type SITE sequence Y description DNA-binding => ECO:0000269|PubMed:18786403 source Swiss-Prot : SWS_FT_FI2 8) chain C residue 225 type SITE sequence R description DNA-binding => ECO:0000269|PubMed:18786403 source Swiss-Prot : SWS_FT_FI2 9) chain C residue 209-215 type prosite sequence WKNSIRH description FORK_HEAD_2 Fork head domain signature 2. WKNSIRH source prosite : PS00658 10) chain C residue 212 type MOD_RES sequence S description Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:18786403, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:21245099 source Swiss-Prot : SWS_FT_FI3 11) chain C residue 218 type MOD_RES sequence S description Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:18786403 source Swiss-Prot : SWS_FT_FI4 12) chain C residue 234 type MOD_RES sequence S description Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:18786403 source Swiss-Prot : SWS_FT_FI4 13) chain C residue 235 type MOD_RES sequence S description Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:18786403 source Swiss-Prot : SWS_FT_FI4

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